Derinatum treats runny nose, sinusitis, otitis, adenoids and many other diseases of the ENT organs in children, as well as skin diseases, conjunctivitis, and colds. In this article we will consider in detail the instructions for using derinat for children.
Derinat is a DNA-containing immunomodulator developed by Russian developers of JSC FP Tekhnomedservice, which in lately It is popular not only among adults, but is also often prescribed to children, which is why it receives special attention in pediatrics.
Not all kids are owners strong immunity, and naturally, every parent dreams of seeing their child without a runny nose, fever, or cough. And if the virus has affected the baby, then the excitement and hope for a quick cure does not leave the parents.
The best method of combating any childhood infections is to harden the child. But when the sun, air and water, as well as others traditional methods do not give the desired effect, drugs that correct the immune system of children are rushing to help. One of these remedies is Derinat, and its use helps not only to restore correct work immunity, and also alleviate the symptoms of the disease itself.
The use of Derinat either prevents the occurrence of nasopharyngeal pathologies or contributes to a mild and minimal course of the disease. The drug is safe, easy to use, quickly acts on the body of children, adolescents and adults - these are its main advantages.
Composition, release form, storage
Derinat is a colorless liquid that contains sodium deoxyribonucleate in an amount of 2.5 grams. The product is available in the following forms:
- ampoules (1.5% solution) - for intramuscular injection;
- 0.25% solution for external use in an amount of 10 ml;
- 0.25% dropper bottle (10 ml) - for the treatment of nasopharynx and eye diseases;
- 0.25% spray (10 ml) - this form of Derinat is used to treat the throat in children.
Derinat is stored in a closed bottle at an air temperature of no higher than 20°C. The shelf life of a closed package is up to 5 years, when the drug is opened - until the end of the course of treatment (usually no more than two weeks). The product should not be accessible to children, stored in a room with high humidity and in direct sunlight.
For children, it is better to use Derinat in nasal drops; their price ranges from 180-580 rubles. A throat spray (with a spray) is a little more expensive, its price ranges from about 270-900 rubles, depending on the pharmacy chain and the federal district.
What is treated with Derinat drops?
The drops have anti-allergic, anti-inflammatory, detoxifying, analgesic, antiviral, regenerating and antitumor effect. While taking the drops, the swelling of the mucous membranes decreases, small cracks are epithelialized, and breathing improves.
The main indications for the use of drops are:
- rhinitis of various origins;
- sinusitis;
- nasopharyngitis;
- sinusitis;
- otitis;
- adenoiditis;
- laryngitis;
- viral infections;
- pathological processes of the mucous membranes in oral cavity;
- bronchopulmonary diseases;
- tonsillitis;
- pharyngitis;
- allergies;
- bronchial asthma;
- violation of the integrity of the skin (including ulcerative pathologies);
- ophthalmological (eye) diseases;
- gastrointestinal diseases (gastritis, ulcers);
- burns;
- arthritis;
- oncological processes.
Derinat can be used as monotherapy or as part of complex treatment. In the treatment of these diseases, the drug not only helps strengthen the immune system, but also actively suppresses bacteria, viruses and fungal microflora.
Important! Children are allowed to drip Derinat from the very beginning. early childhood(from the first day of life), which makes it possible to solve the problems of immune disorders in infants, when pediatricians do not have many approved drugs for this age in their arsenal.
The drug does not cause vasospasm, therefore Well tolerated by babies.
To the delight of many parents, Derinat has only one contraindication - individual intolerance. Therefore, there is also no need to talk about any side effects.
Sometimes, while using Derinat, there may be symptoms that coincided purely by chance with taking the drug. For example, a child has diarrhea, but this does not mean that the baby has indigestion due to the drug; there are many reasons that cause intestinal problems.
Detailed articles on the treatment of diseases in children:
- nasal polyps - how to treat without surgery;
How to properly use Derinat for a runny nose in a child (instructions)?
The drug is indicated for everyone: from newborns to the elderly. Often on the Internet, parents try to find children's instructions for using Derinat, but there are none. It’s just that in the official package insert for Derinat, taking the drug is prescribed taking into account age standards.
Method of use and dosage of Derinat for children
It should immediately be noted that in a separate official instructions There is no information on the use of Derinat for children under one year of age, because the drug is non-toxic and harmless, and the instructions mainly single out the pediatric or adult category of patients.
Children from birth to 12 months are prescribed only an individual treatment regimen determined by a neonatologist or pediatrician.
- for preventive purposes During an unstable epidemiological situation, regular instillations (2-4 times a day) of Derinat drops are carried out. Usually, two drops are placed in each nostril and prophylactic use is continued for up to 14 days;
- if the child has already “caught” a cold or a viral infection, the dosage regimen becomes more frequent, and instillations are carried out every 1.5-2 hours;
- in the presence of sinusitis and adenoiditis, the following scheme is shown: 3-5 drops of Derinat in each nostril up to 6 times a day. The course of therapy is at least 15 days;
- the mucous membranes of the oral cavity are irrigated with a spray up to 6 times a day, 2-3 sprays on the affected areas. A course of irrigation is prescribed for up to 10 days or individually;
- in ophthalmology drops are used, they are instilled into the conjunctiva of the eye(basically 2 drops in each eye for up to 10 days). The course of therapy depends on the eye disease; for dystrophic disorders, Derinat drops are used for a long time, more than a month;
- for the treatment of skin diseases sprays and dressings with Derinat solution are used. Depending on the severity of skin damage, the duration and frequency of procedures can vary from several days to months. It is better to treat burn lesions using a nebulizer (spray) 4-8 times a day;
- for tuberculosis and oncological processes Intramuscular administration of the drug is used. Therapy is carried out only under the supervision of TB specialists or oncologists; the dosage of the drug for these terrible ailments is purely individual for each clinical picture.
Despite the safety of the drug, even with all less dangerous diseases, the course of treatment and doses are selected only by pediatricians. Derinat is not just some water, but a medicine that regulates the human immune system, therefore the attitude towards it should be appropriate.
Does Derinat belong to homeopathy?
The immune system is like the first violin, on which all coordinated activities of the body depend. As you tune it, it will “sing.” The action of Derinat is similar to homeopathic remedies, but still the drug belongs to DNA-containing products.
Clinical trials conducted by Russian scientists have shown that the drugs Derinat and Ferrovir are able to suppress the replication (renewal) of viruses, which shows their high efficiency against many DNA and RNA viruses. There is no getting used to Derinat.
How to use - video
Is it possible to do inhalations with Derinat for children?
Of course you can. This method is widely used in the treatment of upper respiratory tract in children, especially in those who are often ill, and the effect of treatment occurs in some cases faster than from the use of drops and spray.
It is best to carry out inhalations using a nebulizer at home, where the child will feel calm and comfortable.
For diseases of the upper respiratory tract and bronchial asthma, the following dilution of the drug is recommended: 2 ml of a 0.25% solution of Derinat is diluted with 2 ml of saline solution.
According to the instructions for use for the nebulizer, medicinal substance(Derinat + saline solution) is placed in a special container, and the child is offered to breathe in medicinal vapors (the product is ideal for treating the throat).
Inhalations can be carried out once for 5-10 minutes, and the procedures can also be divided into two doses of 5 minutes each (morning and evening). The course of treatment is determined by the doctor; on average, 4-10 days of inhalation are sufficient.
For obstructive bronchitis (COB), prolonged viral infection, bronchial asthma, the following dilution scheme is recommended: 1 ml of 1.5% Derinat is diluted with 3 ml of saline and the inhaler (nebulizer) container is filled. The course of treatment is at least 5 days.
Are there any analogues of Derinat for children?
To analogues of the drug active substance include the following means: Panagen, Deoxynate, sodium Deoxyribonucleate. All of them are made from the milt of sturgeon salmon fish. The most high concentration sodium deoxyribonucleate is found in Derinat.
If you replace Derinat with immunomodulators not based on composition, but on the effect of the drug on the body, then you can often find Grippferon prescribed.
What is better Grippferon or Derinat?
Derinat is a drug wide application, starting from viral infections, ending oncological diseases, and Grippferon is used only during epidemics, as an immunomodeling agent with antiviral effect. The first one can be used for a longer time. Another drug, in addition to individual intolerance, has another contraindication for use - severe allergic diseases.
Derinat has 4 release forms, and Grippferon has one - drops.
As immunomodulator analogues for treatment respiratory system also used in children the following drugs: IRS-19, Bronchomunal, Imudon, Ribomunil, immunoglobulins, VP4 vaccine.
If a child gets sick several times a year, then at first you should not resort to pharmacy immune drugs, including Derinat. You can regulate immunity through proper nutrition and vitamins.
You should maximize your diet with cereals, fruits, vegetables, and fish. If the child does not suffer from allergies, then preventive use of garlic and onions is recommended - these are reliable natural remedies, helping to restore immunity in children and adults.
Registration number P N00291602-051212
Trade name
Derinat®
International generic name or group name
Sodium deoxyribonucleate
Chemical name
Sodium deoxyribonucleate
Dosage form
Solution for external and local use
Compound
Active substance sodium deoxyribonucleate - 2.5 g
Excipients sodium chloride - 1 g; water for injections - 1000 ml
Description
Transparent colorless liquid without foreign inclusions.
Pharmacotherapeutic group: immunomodulatory agents, regenerant, reparant
ATX code: L03, V03AX.
Pharmacological properties
The drug activates cellular and humoral immunity. Optimizes specific responses against fungal, viral and bacterial infection. The drug stimulates reparative and regenerative processes, normalizes the condition of tissues and organs in dystrophies of vascular origin. Derinat promotes the healing of trophic ulcers of various etiologies. Derinat promotes fast healing deep burns, significantly accelerating the dynamics of epithelization. Upon recovery ulcerative formations On the mucous membrane, under the influence of Derinat, scarless restoration occurs. The drug does not have teratogenic or carcinogenic effects.
Pharmacokinetics
Derinat at local application quickly absorbed and distributed in organs and tissues using the endolymphatic transport pathway. During the phase of intensive drug entry into the blood, redistribution occurs between plasma and shaped elements blood, in parallel with metabolism and excretion. Derinat is metabolized in the body. It is excreted from the body (in the form of metabolites) partially with feces, and, to a greater extent, with urine according to a biexponential dependence.
Indications for use
Monotherapy
- acute respiratory diseases (ARI);
- prevention and treatment of acute respiratory viral infections (ARVI);
- ophthalmology inflammatory and dystrophic processes;
- inflammatory diseases mucous membranes of the oral cavity;
Complex therapy:
- chronic inflammatory diseases, fungal, bacterial and other infections of the mucous membranes in gynecology;
- acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis, sinusitis, sinusitis);
- obliterating diseases lower limbs;
- trophic ulcers, long-term non-healing and infected wounds(including diabetes mellitus);
- gangrene;
- burns, frostbite;
- haemorrhoids;
- post-radiation necrosis of the skin and mucous membranes.
Contraindications
Individual intolerance.
Directions for use and doses
The drug is prescribed to children from the first day of life and to adults. To prevent ARVI, instill 2 drops into the nose or 1 spray into each nasal passage 2-4 times a day for 1-2 weeks. When symptoms appear colds» the drug is instilled into the nose, 2-3 drops in each nasal passage or 1-2 sprays in each nasal passage every 1-1.5 hours, during the first 24 hours; then - 2-3 drops or 1 spray in each nasal passage 3-4 times a day, course duration - 1 month.
For inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops or 1-2 sprays into each nasal passage 4-6 times a day. Course duration is 7-15 days.
For diseases of the oral mucosa, rinse with the drug 4-6 times a day (1 bottle - 1-2 rinses) or the drug is evenly sprayed onto the corresponding damaged areas of the mucous membrane, 2-3 sprays 4-6 times a day. The duration of treatment is 5-10 days.
For chronic inflammatory diseases, fungal, bacterial and other infections in gynecology, intravaginal administration with irrigation of the cervix or intravaginal administration of tampons with the drug, 5 ml per procedure, 1-2 times a day for 10-14 days.
For hemorrhoids, the drug is prescribed as microenemas of 15-40 ml into the rectum. The duration of treatment is 4-10 days.
For severe inflammatory and dystrophic processes in ophthalmology, Derinat is instilled into the eyes 2-3 times a day, 1-2 drops, for 14-45 days.
For obliterating diseases of the lower extremities, the drug is instilled into the nose, 1-2 drops in each nasal passage 6 times a day, course duration is up to 6 months.
With post-radiation necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene, application bandages (gauze in two layers) are applied to the affected areas with the drug applied to it 3-4 times during the day, or the affected surface is treated with the drug from a sprayer 4-5 times a day, 10 - 40 ml (course of treatment - 1-3 months).
Side effect
In gangrenous processes under the influence of the drug, spontaneous rejection is observed - necrotic masses in the foci of rejection with restoration skin. At open wounds and burns, an analgesic effect is observed.
Overdose
No overdose was detected.
Interaction with other drugs
When applied topically, it is not compatible with fat-based ointments and hydrogen peroxide.
Release form
Solution for external and local use 0.25%. 10, 20 ml in glass bottles in package No. 1; dropper bottle - 10 ml in package No. 1; bottle with nozzle - spray - 10 ml in package No. 1.
Best before date
5 years. Do not use after the expiration date stated on the packaging.
Storage conditions
In a dark place at a temperature from + 4 C to + 20 ° C. Use the contents of the opened bottle within two weeks. Keep out of the reach of children.
Conditions for dispensing from pharmacies
Over the counter.
Manufacturer / organization receiving complaints
CJSC FP Tekhnomedservis, Russia.
Derinat is a well-known immunomodulatory agent indicated for use in numerous diseases. The drug is produced in several forms.
A solution for intramuscular administration is used for systemic immunostimulation in such pathologies as, for example, rheumatoid arthritis, atherosclerosis of the extremities, etc.
In the form of a spray, the drug is used to increase the immunity of the throat mucosa. However, the most common form of Derinat is drops. They are often used in the treatment of respiratory infections, as well as for preventive purposes.
Composition and form of Derinat drops
Derinat is a clear, colorless and odorless liquid.
The active substance - sodium deoxyribonucleate - is isolated from biological material, obtained from sturgeon fish.
1 ml of Derinat drops contains 2.5 mg of sodium deoxyribonucleate dissolved in 0.1% sodium chloride solution (common salt).
The drug is available in glass bottles of 10 ml and 20 ml, equipped with a drip dispenser.
Instructions for using Derinat nasal drops
Drops are instilled according to the instructions: 
- Sit down and tilt your head back, or take a lying position.
- Turn your head to the left.
- Place 2-5 drops (depending on the purpose) into the left nasal passage.
- Pinch the left nostril with your finger and make several circular massaging movements so that the drug is evenly distributed throughout the mucous membrane.
- Turn your head to the right.
- Repeat steps 3-4 for the right nasal passage.
For the treatment of viral respiratory disease Derinat is instilled every 1.5 hours or even more often. For preventive purposes, it is sufficient to use the drug three times a day.
Derinat drops for children
Sometimes you can hear the phrase “Derinat baby drops.” In reality, there is no special pediatric form of the drug. Instillation for children does not have any significant differences from the standard adult procedure. The single dosage should be reduced:
- children under 2 years old - 1 drop in each nasal passage;
- 2-10 years - 2 drops;
- over 10 years old - 3-4 drops.
Is Derinat possible for newborns and infants?
In accordance with the instructions for using Derinat nasal drops, they can be used without age restrictions. For very young children, drops can be placed not only in the nose, but also in the mouth - to stimulate the local immunity of the throat. This drip form compares favorably with sprays that cannot be used on small children.
Despite the fact that Derinat has no age restrictions, the question of the advisability of using any immunostimulating agent is the subject of discussion even among doctors. On the one hand, the child’s immune system is in the “training” stage: it consistently becomes familiar with emerging microbial threats, remembers them, and reacts strongly to viral and bacterial attacks. Many doctors believe that it is not worth interfering with this process. On the other hand, Derinat drops belong to the class of safe immunomodulatory agents, which, moreover, are applied topically.
Derinat's action is to stimulate the body's production of its own interferon, a substance that plays a key role in the launch defensive reactions body. Most doctors are inclined to believe that there is nothing dangerous in modulating the interferon system.
During pregnancy and lactation
The instructions for using Derinat drops note that the drug is quickly absorbed after instillation. It is noted that sodium deoxyribonucleate does not have a toxic effect on the fetus. However, the question of the need to use Derinat drops during pregnancy, incl. in the 1st trimester, remains open. By general rule Women in this situation are advised to avoid taking any medications. On the other hand, Derinat is one of the safest immunomodulators. Obviously, in a situation of choice between this drug and the probable use of antibiotics in the event of development bacterial complication It is advisable to give preference to preventive administration of an immunomodulator.
The instructions do not pay attention to the issue of using the drug during lactation. It is believed that lactating women can use drops without unnecessary worries.
Indications for use
Drops shown:
- for viral respiratory diseases;
- for bacterial acute and chronic diseases respiratory tract;
- in ophthalmology - for eye treatment;
- in dentistry - for inflammation of the oral mucosa and gum tissue.
Let's consider the use of Derinat for inflammatory diseases of the upper respiratory tract.
Derinat for runny nose
The drug should be started at the first symptoms. The instructions for use note that it stimulates the immune system against both viruses and bacteria. For a runny nose of a viral nature, Derinat drops can be used as monotherapy.
How to distinguish a viral runny nose from a bacterial one?
Starting to highlight increased amount secretion, the mucous membrane tries to “wash away” microorganisms from the nasal cavity. Bacteria live in most people's noses. However, their number does not exceed certain limits - in this case it is customary to talk about the opportunistic status of microorganisms. Unlike bacteria, viruses are always pathogenic: when they enter the human respiratory tract, they immediately penetrate the mucosal cells and begin to duplicate in them. Thus, in most cases, a sudden runny nose has a viral cause.
The main danger of viruses is their suppressive effect on the immune system. As a result of suppression immune reaction The body's protective functions are reduced, which contributes to the transition of bacteria from an opportunistic to a pathogenic state.
However, in some cases, a primary bacterial rhinitis occurs. A decrease in protective functions can occur not only under the influence of the virus, but also for other reasons, for example:
- hypothermia;
- smoking;
- immunodeficiency states.
Derinat drops have a local immunostimulating effect for a runny nose caused by any microbial cause. However, with bacterial rhinitis, as well as with a late start of treatment, drops will not be enough: it is necessary complex therapy using antibacterial agents.
Dosage: 3 drops (x 2) on the first day every hour and then every 4 hours.
Derinat for sinusitis
Derinat is not a treatment. However, as a preventative medicine, it is recommended for use by persons suffering from chronic sinusitis, during periods of seasonal rise in respiratory diseases. Since exacerbation of sinusitis always develops against the background of a runny nose, preventing its development is of paramount importance.
As part of complex antibacterial and anti-inflammatory therapy, Derinat is prescribed as a means of supporting the immune system.
Dosage: 5 drops (x 2) every 3 hours.
Derinat for adenoids
Derinat drops are not a treatment drug. However, ENT doctors and pediatricians often prescribe this drug to stimulate the local immunity of the nasopharynx.
Derinat is instilled into children with adenoiditis, 1-2 drops (x 2) three times a day for up to 6 months. The duration of treatment should be determined by the doctor.
Preventive instillation of Derinat
For prophylaxis, drops are recommended to be used during the seasonal rise in incidence respiratory infections. Traditionally, children, the elderly, and people at risk are long time conductive surrounded large cluster people.
Dosage - 2 drops (x 2) three times a day for 10-14 days.
Other types of drug
The composition of the spray is similar to drops. The bottle has a spray dispenser and an elongated tube, with which it is convenient to apply the product to the mucous membrane of the mouth or throat. The spray form is indicated in the following cases:
Some reviews note rare cases of individual intolerance to medicinal drops. An allergic reaction to the drug is possible.
Derinat - immunomodulatory agent third generation, developed in Russia in the 90s of the last century. The instructions state that it strengthens the immune system and helps the body fight harmful microflora. Therefore, mothers took the medicine into service for the prevention and treatment of colds in children. Does the drug really help maintain health and is it safe?
Derinat - natural immunomodulator Russian production.
Composition and effect of the drug
Active ingredient Derinata is a purified sodium salt of deoxyribonucleic acid, extracted from the milt of salmon and sturgeon fish. Excipients complement the composition:
- table salt (sodium chloride);
- distilled water.
Derinat is an immunomodulator, i.e. a remedy that does not have a direct effect on pathogenic flora, such as antifungal or antibacterial drugs. He's just helps the body form antibodies to pathogens:
- viruses;
- fungi;
- bacteria.
The medicine improves the child’s local immunity.
The formed cells kill infectious agents.
Recovery occurs due to the internal forces of the child’s body. Derinat only helps to activate protection, and main role in the fight gives immunity.
Another property of the drug is accelerating the regeneration of damaged tissues. Thanks to it, the skin is restored without scarring, even after deep burns.
Indications
Derinat is usually prescribed to children for treatment and prevention of:
- flu;
- ARVI.
The drug is able to prevent these infections alone (without other drugs).
The instructions for use also list the following indications:
- ophthalmological diseases associated with metabolic disorders or inflammation;
- inflammation of the oral mucosa;
- gynecological diseases of fungal or bacterial nature;
- diseases of the upper and lower respiratory tract, acute or chronic;
- frostbite and burns;
- allergy;
- non-healing wounds with or without infection, trophic ulcers;
- gangrene;
- post-radiation death of mucous membranes or skin.
This list assumes the use of Derinat in combination with other agents.
Derinat is both medicinal and prophylactic.
Manufacturers, prices, release forms
Derinat is produced Russian company CJSC FP "Tehnomedservice" in four forms:
- drops, 10 ml (in pharmacies they cost about 300 rubles);
- spray, 10 ml (from 260 rubles);
- solution for local and external use, 10 ml (average 240 rubles);
- solution for intramuscular administration, 5 bottles of 5 ml (price from 1800 rubles).
Children are usually prescribed nasal drops.
All forms of release are colorless and clear liquid. They have the same composition, but different concentrations of the active component.
For children, Derinat is usually prescribed as nasal drops or a spray to treat flu and colds. The solution for external use is rarely used (when there is damage to the mucous membranes or skin). The drug is administered intramuscularly only for severe illnesses.
Marina writes in her review:
“The pediatrician prescribed Derinat when my 4-month-old son caught a cold. First we bought a spray. But it turned out to be inconvenient to use: with one hand you need to hold the baby in vertical position, and the second is a bottle. At the same time, you also need to carefully insert the tip into the spout and irrigate it. I immediately purchased the drops. When the child is lying down, it is easier to instill the medicine.”
Dosage and administration
Derinat is suitable for patients of all ages: The drug can be given even to newborns. Children tolerate treatment with it well because it has neither taste nor smell.
The course of treatment and dose will be selected by your pediatrician.
Only drops, spray and solution for external use are freely available in pharmacies. Therefore, when talking about how to take the medicine correctly, we will have in mind only these release forms.
| Indications | Recommended form of medication | Prevention (dosage and duration) | Treatment (dosage and duration) |
| Acute respiratory infections, acute respiratory viral infections and influenza | Spray | 1 irrigation 2 to 4 times a day for 1-2 weeks. | 1-2 irrigations every 60-90 minutes on the first day. Then 1 month - 1 irrigation 3-4 times a day. |
| Drops and solution | Instill 2 drops 2-4 times a day for 1-2 weeks. | 2-3 drops in the nose every 60-90 minutes in the first 24 hours after the onset of symptoms. Then 1 month - 2 drops 3-4 times a day. | |
| Inflammation of the nasal cavity and paranasal sinuses | Spray | - | 1-2 irrigations 4 to 6 times per day for 7-15 days. |
| Drops and solution | - | 3-5 drops 4-6 times a day from 7 to 15 days. | |
| Inflammation in the mouth | Spray | - | 2-3 irrigations of the affected area of the mucosa 4 to 6 times per day for 5-10 days. |
| Drops and solution | - | Rinse the cavity 4-6 times a day for 5 to 10 days (consumption: 1 bottle for 2-3 rinses). |
Renata writes:
“I believe that it is better to frequently carry out prevention than to be treated for an infection that has already entered the body. Therefore, I always keep Derinat drops in the family medicine cabinet and give them to children during outbreaks of ARVI and influenza, and I also take them myself. It seems to me that this helps us get sick less often and cope with colds more easily.”
Derinat solution and drops can be used for inhalation using a nebulizer in the treatment of acute respiratory diseases, bronchitis and bronchial asthma. Children's dosage of the drug is 1-2 ml per procedure (diluted in the same amount saline solution). Course of treatment: 5-10 days.
Inhalations - effective way treatment with Derinat.
Contraindications and side effects
The product has the only contraindication - individual intolerance sodium salt deoxyribonucleic acid. Therefore, monitor the reaction of the child’s body after the first dose of the drug. When allergic reactions stop treatment and show the child to the doctor.
Interaction with other drugs
Derinat cannot be used externally in conjunction with fat-based ointments and hydrogen peroxide.
Derinat: pros and cons
Why should we be careful when using Derinat? After all, the drug has natural origin, and this should guarantee the safety of treatment with it.
Doctors suspect that the drug provokes changes that may take several years to appear.
But Derinat’s opponents present their own arguments:
- The drug is new and therefore not well studied. Since the product contains deoxyribonucleic acid (DNA) from salmon, there is no certainty that chromosomal changes in cells will not be detected after decades little patient(no longer small by that time) and his future children.
- Parents believe that immunomodulators increase the body's defenses without consequences. However, this group of drugs is only enhances some immune functions by inhibiting others, less important for a child during illness. And if all the components immune system weakened, then there will be no effect from the treatment: if there are no protective forces at all, then where do they come from? Consult an immunologist to find out if Derinat will help your child.
- In children, immunity is at the stage of formation. And for the successful completion of this stage The child needs to get over everything that people usually get sick with in preschool age. Komarovsky claims that this is necessary to strengthen the immune system. If immunomodulators interfere with its work, it will lose its functions. Evgeny Olegovich offers to help children's body proper nutrition. The diet must include cabbage, onions, garlic, radish, honey, rose hips and beets.
Attention! If you are in doubt about whether to give your baby Derinat as a prophylactic, for your peace of mind, replace it with a time-tested drug: tincture of ginseng, eleutherococcus or echinacea. Their effects on the body have been well studied, so there is no doubt about their effectiveness and safety.
Analogues of the drug
Derinat, to achieve the same effect, can be replaced with drugs with an identical composition or drugs with a different composition but a similar effect.
Analogs for the active substance:
- Deoxynate;
- Sodium Deoxyribonucleate.
The composition, indications and action of these drugs are the same. The difference is only in name.
Antiviral drugs with similar action:
- . Active ingredient - human interferon(a protein formed in the body when infected by viruses to destroy them). Available in the form of drops (cost about 250 rubles), ointment (average 200 rubles) and spray (approximately 360 rubles).
- (as part of an antibody to human interferon). These are pills white 20 pieces per package. Average price- 170 rubles.
- (Echinacea extract). Available in the form of tablets and solution. Both forms of the drug can be found in pharmacies at a price of 300 to 400 rubles.
Analogue of Derinat - Immunal.
Alice left a review:
“With the first signs of ARVI in our three-year-old daughter, we went to the clinic, where we were prescribed Derinat. The pharmacy did not have this drug. So I asked the pharmacist what I could replace it with to cope with initial signs colds. I already came out with Aflubin - drops for internal use. I gave it according to the instructions, and after a couple of days my daughter already looked healthy.”
Derinat is an immunomodulatory agent successfully used for prevention and treatment infectious diseases, accelerating the healing of wounds and burns. To date, the effect of the drug on the body has not yet been fully studied. Therefore, you need to use it carefully: do not give the medicine to your child unless absolutely necessary.
Alisa Nikitina
Derinat is a highly effective immunomodulator that affects cellular and humoral immunity. The safety and reliability of this drug has been clinically proven.
The active component - sodium deoxyribonucleate - stimulates reparative processes, has anti-inflammatory and analgesic effects, normalizes the condition of tissues during dystrophic changes vascular origin. In addition, the drug exhibits lymphotropic, cardioprotective and anti-ischemic properties, the qualities of an antioxidant and membrane stabilizer, and has a weak anticoagulant effect.
On this page you will find all the information about Derinat: full instructions as applied to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Derinat. Would you like to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Immunomodulator.
Conditions for dispensing from pharmacies
Dispensed without a doctor's prescription.
Prices
How much does Derinat solution cost? The average price in pharmacies is 250 rubles.
Release form and composition
The drug is available in the form of a 0.25% solution of 10 and 20 ml in the form of a 10 ml dropper bottle, a bottle with a spray nozzle of 10 ml. Compound:
- 2.5 mg sodium deoxyribonucleate;
- 1 mg sodium chloride.
Also in the form of a 1.5% solution for intramuscular injection. Compound:
- 15 mg sodium deoxyribonucleate
- 1 mg sodium chloride.
Pharmacological effect
Derinat activates the body's own cellular and humoral immunity:
- acts on B-lymphocytes and macrophage cells;
- includes the T-helper defense mechanism, which is involved in enhancing the formation of antibodies;
- increases the rate of intracellular metabolism.
Under the influence of derinat, T-killer lymphocytes are activated, the target of which are body cells affected by pathogenic microorganisms.
Derinat reduces concentration free radicals, increases resistance to infections, activates work lymphatic system, which helps detoxify the body. The drug has cardioprotective properties due to its stabilizing effect on cardiac muscle cells, improves blood circulation, and restores the mucous membrane.
Indications for use
As monotherapy Derinat in the form of a solution for local and external use used for the following diseases:;
- (treatment and prevention);
- Dystrophic and inflammatory diseases eye;
- Inflammatory diseases of the oral mucosa
- Acute respiratory diseases (ARI).
Included complex treatment solution for local and external use prescribed for the treatment of diseases such as:
- Gangrene;
- Post-radiation necrosis of the skin and mucous membranes;
- Frostbite;
- Burns;
- Chronic and acute diseases upper sections respiratory tract (rhinitis, including);
- Fungal, chronic inflammatory diseases, bacterial and other infections of the mucous membranes in gynecological practice;
- Infected and persistently non-healing wounds (including with);
- Obliterating diseases of the lower extremities.
Derinat in the form of a solution for intramuscular administration used in the treatment of diseases/conditions such as:
- Hematopoiesis disorder;
- Radiation injuries;
- Purulent-septic complications, odontogenic;
- Long-term non-healing wounds, trophic ulcers;
- , inflammatory diseases of the respiratory tract;
- Burn disease;
- Endometritis, endometriosis, salpingoophoritis, fibroids;
- Chronic obstructive pulmonary diseases;
- Benign hyperplasia prostate gland, ;
- Stomatitis induced by cytostatic drugs;
- Erosive gastroduodenitis, and duodenum;
- Obliterating diseases of the vessels of the lower extremities (stage II-III);
- Coronary heart disease (CHD);
- Resistance and myelosuppression to cytostatics in cancer patients associated with radiation and/or cytostatic therapy (stabilization of hematopoiesis, reduction of myelo- and cardiotoxicity of chemotherapy drugs);
- Pre- and postoperative periods(in surgical practice).
Contraindications
Injections and drops of Derinat have no other contraindications, except for the patient’s intolerance to the components included in its composition.
Use during pregnancy and lactation
The patient should be warned that before using the drug during pregnancy and lactation, consultation with a doctor is necessary. If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be assessed.
Instructions for use
The instructions for use indicate that Derinat in the form of a solution for external and local use is prescribed depending on the location of the pathological process.
The drug is prescribed to children from the first day of life and to adults:
- For inflammatory diseases of the oral cavity, rinse the mouth with a solution of the drug 4-6 times a day (1 bottle for 2-3 rinses). The duration of the course of therapy is 5-10 days.
- For inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops into each nasal passage 4-6 times a day; Course duration is 7-15 days.
- To prevent ARVI, instill 2 drops into each nasal passage 2-4 times a day for 1-2 weeks. When symptoms of a respiratory disease appear, the drug is instilled 2-3 drops into each nasal passage every 1-1.5 hours during the first day, then 2-3 drops into each nasal passage 3-4 times a day. The duration of the course of therapy is from 5 days to 1 month.
- For chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice - intravaginal administration of tampons with the drug or irrigation of the vagina and cervix 5 ml per procedure 1-2 times a day for 10-14 days.
- In ophthalmological practice, for severe inflammatory and dystrophic processes, Derinat is instilled into the eyes, 1-2 drops 2-3 times a day for 14-45 days.
- For hemorrhoids, the drug is administered rectally using microenemas of 15-40 ml. The duration of treatment is 4-10 days.
- In case of post-radiation necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene, it is recommended to apply application bandages (gauze in 2 layers) to the affected areas with the application of the drug 3-4 times a day or treat the affected area surfaces with the drug from a spray bottle 10-40 ml 4-5 times a day. The course of treatment is 1-3 months.
- For obliterating diseases of the lower extremities, in order to achieve a systemic effect, the drug is instilled 1-2 drops into each nasal passage 6 times a day, the course duration is up to 6 months.
Instructions for Derinat injections
For adults, Derinat in the form of a solution for intramuscular administration is administered over 1-2 minutes at an average single dose of 75 mg (5 ml of solution for intramuscular administration of 15 mg/ml). The administration interval is 24-72 hours.
Depending on the indications, the following treatment regimens are used:
- Peptic ulcer of the stomach and duodenum - 5 ml of a solution of 15 mg/ml, interval between injections - 48 hours. Treatment course– 5 injections;
- Tuberculosis - 5 ml of a 15 mg/ml solution, break between injections - 24-48 hours. Treatment course – 10-15 injections;
- Coronary heart disease - 5 ml of a 15 mg/ml solution, break between injections - 48-72 hours. Treatment course – 10 injections;
- Oncological diseases - 5 ml (75 mg per day), break between injections - 48-72 hours. Treatment course – 10 injections;
- Chronic inflammatory diseases - 5 ml of a solution of 15 mg/ml: the first 5 injections with a break of 24 hours each, subsequent ones - with an interval of 72 hours. Treatment course – 10 injections;
- Benign prostatic hyperplasia, prostatitis – 5 ml of a 15 mg/ml solution, break between injections – 24-48 hours. Treatment course – 10 injections;
- Chlamydia, endometriosis, endometritis, mycoplasmosis, ureaplasmosis, fibroids, salpingoophoritis - 5 ml of a 15 mg/ml solution, break between injections - 24-48 hours. Treatment course – 10 injections;
- Acute inflammatory diseases - 5 ml of a 15 mg/ml solution, break between injections - 24-72 hours. Treatment course – 3-5 injections.
When using a solution of 15 mg/ml, 2 ml injections should be carried out every day, recalculating, until a dose of 375-750 mg per course is reached.
Side effects
The instructions for use indicate that this medication is well tolerated by the body. Side effects Derinata are completely absent, with the exception of the appearance of local and allergic reactions as a consequence hypersensitivity to the components of the drug.
The manufacturer reminds skin rashes in the form of urticaria, which are complemented by itching, burning sensation, and hyperemia of the skin.
Overdose
No cases of drug overdose have been recorded.
Special instructions
Numerous experimental and clinical laboratory studies have proven the absence of mutagenic, teratogenic, embryotoxic, carcinogenic effects, allergenic properties, and cytogenetic effects; its moderate antimutagenic effect was revealed.
In case of gangrenous processes under the influence of the drug, spontaneous rejection of necrotic masses in the foci of rejection is observed with restoration of the skin. For open wounds and burns, an analgesic effect is noted.
Drug interactions
When applied topically, the drug is not compatible with hydrogen peroxide and fat-based ointments.
The use of the drug in combination with the main therapy increases healing effect and shortens the duration of treatment. This also makes it possible to reduce the doses of antibiotics and antiviral drugs.
The use of Derinat increases the effectiveness of therapy with antitumor anthracycline antibiotics and cytostatic drugs; the effect of basic therapy prescribed to patients with peptic ulcer; the iatrogenicity of drugs prescribed for treatment decreases rheumatoid arthritis(up to 50-70%, which is also accompanied by an improvement in the number comprehensive indicators disease activity).
In cases where surgical infection provokes the development of sepsis, the introduction of Derinat into combination therapy allows:
- normalize hematopoietic function;
- improve the performance of organs involved in removing toxins from the body;
- reduce the level of intoxication in the body;
increase the activity of the immune system.