De-nol is a drug that was created for the treatment of gastric or duodenal ulcers. The active ingredient of this medicine is bismuth. Once in the stomach, De-nol forms a film on the surface of the erosion that protects the ulcerated mucosa from the destructive effects of acids and other aggressive substances. Also, this medicine stimulates the rapid healing of ulcers. Another important property of this drug is its ability to destroy the bacteria Helicobacter pylori, which play an important role in the development of peptic ulcers. Bismuth, which is part of De-nol, forms insoluble compounds and is almost not absorbed from the gastrointestinal tract. All this allows the use of this drug for peptic ulcers of various etiologies in the acute stage; for gastritis and gastroduodenitis; for ulcerations of the mucous membrane while taking non-steroidal anti-inflammatory drugs; for dyspeptic disorders, against the background of irritable bowel syndrome.
Contraindications:
De-nol is produced in tablet form. The detailed instructions for the drug describe how it should be taken. It is not recommended to use this drug in case of hypersensitivity to one of its components or kidney dysfunction. De-nol should not be taken while pregnant and breastfeeding.
Side effects:
Treatment with this drug may cause side effects such as constipation or diarrhea, nausea and vomiting, black stool. Allergic reactions may include the appearance of an itchy rash; anaphylactic shock has been observed very rarely. Long-term use of this drug can lead to the accumulation of bismuth in the body and poisoning with it. Symptoms of overdose are also described: digestive disorders, inflammation of the mucous membranes of the mouth, bluish darkening of the gums, impaired renal function. Obviously, if you suspect possible poisoning, you must stop taking the drug and seek qualified medical help.
Reviews about De-nol
The drug is not discussed very often, so finding reviews about the effectiveness of De-nolane is so easy. Usually, the name of this medicine can be found in the description of doctor’s prescriptions, which patients quote on forums. However, among such references, we were able to find several reports that this drug had a noticeable beneficial effect on gastritis and peptic ulcers. Several people noted that they experienced a side effect of De-nol - severe diarrhea. However, they completed the entire course of treatment and, upon completion, the dyspeptic symptoms ceased.
If your health is undermined by a peptic ulcer or gastritis, you should not self-medicate. The patient’s task is not to find the most effective drug based on reviews, but to find a competent specialist and strictly follow his recommendations. And if you have been prescribed De-nol, then you need to take this drug in strict accordance with the instructions, since the effectiveness of the treatment will depend on this.
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De-Nol is a colloidal bismuth drug that is used to treat functional diseases caused by the bacterium Helicobacter pylori in the abdominal area:
- gastritis;
- stomach ulcer;
- ulcerative intestinal lesions.
The country of origin of the drug De-Nol is the Netherlands, the pharmaceutical company is Astellas Pharma. Release form: tablets.
On one half of the tablet there is an inscription - gbr 152, on the other - a graphic design in the form of a square. The tablets have a barely noticeable odor of ammonia.
The tablets have a biconvex shape, are coated in a beige color and sealed in a blister. They produce 2 types of packages - 56 and 112 tablets per package.
The colloidal bismuth molecule is the main active ingredient of the drug.
Advantages of De-Nola:
- Does not cause Helicobacter pylori resistance to bismuth.
- It has the most powerful antimicrobial effect than similar bismuth preparations.
- Has a wide spectrum of action.
- Quick effect.
- Combination treatment with the drug helps to avoid Helicobacter resistance to Metronidazole.
- More purified, it has a minimal set of side effects compared to analogues.
- Accessible.
Disadvantages of De-Nol:
- undemocratic pricing policy;
- prescription dispensing;
- toxic effect on the fetus - not allowed during pregnancy and lactation.
pharmachologic effect
Pharmacokinetics and pharmacodynamics The antiulcer effect is characterized in three ways:
Under the influence of bismuth, the production of gastric enzymes decreases and stimulates the production of EGF, thereby restoring the mucous membrane. De-Nol acts locally on the area of ulcerative lesions.
- Anti-Helicobacter (antimicrobial) action.
Helicobacter pylori is a bacterium whose pathological reproduction causes peptic ulcers. Bismuth salt has a detrimental effect on this bacterium.
Due to the fact that bismuth subcitrate has a colloidal form, it changes the structure of Helicobacter and destroys it.
- Antioxidant action. De-Nol components reduce the effect of toxic enzymes of Helicobacter pylori. This increases the body’s resistance to bacteria. The fact that bismuth is present in the preparation in colloidal form makes it possible to exhibit a therapeutic effect in minimal quantities.
De-Nol is practically not absorbed into the general bloodstream from the gastrointestinal tract. It is eliminated from the body through feces and urine.
Indications for use of De-Nol
The drug is prescribed for the following diseases caused by the bacterium Helicobacter pylori:
- chronic erosive gastritis in the acute phase;
- stomach and intestinal ulcers;
- acute gastroduodenitis;
- irritable bowel syndrome with symptoms of diarrhea.
Contraindications
The use of the drug is contraindicated in the following situations:
- with severe renal dysfunction;
- liver failure;
- pregnancy period;
- lactation.
De-Nol: side effects
De-Nol's annotation states that the following side effects may sometimes occur:
- dyspepsia (nausea, vomiting, intestinal upset);
- allergic manifestations in case of bismuth intolerance (urticaria and itching);
- darkening of stool (dark color);
- darkening of the tongue;
- in isolated cases - an anaphylactic reaction.
Overdose
An overdose of the drug may occur in cases of long-term use of tablets that exceed the recommended amount. This can affect kidney function - the level of bismuth in the blood increases. Symptoms go away after you stop taking the drug. If symptoms persist, hemodialysis is recommended.
Signs of poisoning are relieved:
- gastric lavage;
- use of saline laxatives;
- use of activated carbon.
Subsequent treatment is symptomatic.
De-Nol: instructions for use
The drug is basic in the treatment of ulcers and gastroduodenitis caused by X. pylori.
There are various schemes for complex treatment of these diseases. Often, experts prescribe De-Nol in combination with antimicrobial drugs:
- Clarithromycin;
- Amoxicillin;
- Metronidazole;
- Tetracycline;
- Furazolidone.
The first stage of treatment lasts from a week to 10 days in combination with antimicrobial drugs to remove bacteria from the body. To reduce the likelihood of relapse, the course of therapy is extended to 1 month.
After completing the course, it is not recommended to take bismuth-containing drugs for another 2 months. The tablets should be taken with plenty of water. The gastroenterologist prescribes the frequency and duration of treatment individually, depending on the severity of the disease.
How to take De-Nol for children
Tablets are not prescribed to children under 4 years of age.
The frequency of administration differs depending on the age of the child and is regulated by a specialist on an individual basis.
Drug interactions
In order not to affect the effectiveness of the drug De-Nol, it is not recommended to take antacids earlier than 30 minutes before/after taking the medication.
It is not advisable to take the tablets with milk and fruit juices.
Alcohol compatibility
Additional studies regarding the compatibility of De-Nol with alcohol have not been conducted. Therefore, there is no exact data on the consequences of their simultaneous use.
Based on logical reasoning, De-Nol is used for ulcerative lesions of the mucous membrane, therefore alcohol consumption is not allowed during drug therapy.
Alcoholism can worsen the patient's condition or negatively affect the bioavailability of the drug.
special instructions
The course of drug therapy should not exceed more than 2 months. The simultaneous use of drugs that contain bismuth is not recommended.
The number of tablets consumed should not be exceeded as indicated in the instructions for use of De-Nol.
The components of De-Nol react with hydrogen sulfide, causing the stool to turn dark. With long-term use, you may notice a short-term darkening of the tongue.
Use during pregnancy
Colloidal bismuth penetrates the fetal central nervous system (negatively affects the development of the neural tube) and causes a mutation process. At the genetic level, this leads to congenital defects and disorders of intrauterine development.
During the period of therapy with De-Nol, you should stop feeding.
Analogues of De-Nol
Russia, Germany and Ukraine produce pharmacological drugs identical in composition, differing in cost and bioavailability:
- Pills Escape No. 40 and No. 112 tablets in packaging, domestic manufacturer – Pharmstandard, Russia. The average price of a package is from 260 to 750 rubles.
- Pills Ulcavis No. 28, 56, 112 tablets per package. Manufacturer – KRKA, Germany. The average cost of a package, depending on the number of tablets, is from 210 to 590 rubles.
- Pills Novobismol No. 56, 112 tablets per package. Manufacturer – Pharmproekt, Russia. The average price per package is from 370 to 540 rubles.
- Pills Vis-Nol No. 100 per pack. Manufacturer: Farmak, Ukraine.
- Pills Deli No. 100. Manufacturer – Galichfarm, Ukraine.
De-Nola price
You can buy De-Nol at any pharmacy in Russia. The drug is dispensed as prescribed by a doctor.
The cost of the drug per package varies from 490 to 910 rubles, depending on the number of tablets.
Contents of the article: classList.toggle()">toggle
De-Nol is one of the modern means for the treatment of diseases of the gastrointestinal tract. It has a wide spectrum of action, including protecting the surfaces of the stomach on which ulcers and erosions have formed from the negative effects of an acidic environment, thereby accelerating healing.
Release form and mechanism of action
De-Nol is produced in the form of tablets, 8 pieces in blisters. The package may contain 7 or 14 plates.
De-Nol belongs to the group of antiulcer drugs. Its main active ingredient is bismuth subcitrate.
The drug has a wide spectrum of action, namely: antimicrobial, gastrocytoprotective and astringent.
The astringent effect is based on the ability of De-Nol to precipitate proteins, while forming chelate compounds.
A protective film is formed on the surface of the mucous membrane of the duodenum and stomach in the area where ulcers and erosions are located, which helps to avoid the negative effects of an acidic environment. In this case, scarring of the ulcers occurs noticeably faster.
De-Nol has bactericidal activity against Helicobacter pylori. It inhibits enzymatic activity in bacterial cells, thereby destroying it. To date, there is not a single strain that is not susceptible to the effects of bismuth subcitrate. At the same time, it penetrates deep into the mucous membrane, destroying bacteria.
De-Nol also has a gastrocytoprotective effect. It reduces the amount of hydrochloric acid and accelerates cell regeneration.
Indications for use
De-Nol is used for the following diseases:
- , including peptic.
- or ;
- Damage to the gastric mucosa when taking non-steroidal anti-inflammatory drugs;
- Irritable bowel syndrome, with stool disturbances.
Directions for use and dosage
The drug is prescribed to children over 12 years of age and adults. The tablet must be swallowed whole with a sufficient amount of water (not recommended with milk). The duration of treatment is 1 or 2 months, depending on the disease and the extent of the lesion.
Take 4 De-Nol tablets per day according to the following scheme: 1 tablet half an hour before meals (including three meals a day), then 1 tablet before bed.
You can also take 2 tablets, half an hour before eating in the morning and evening.
Complex treatment with the drug is possible:- De-Nol 1 tablet twice a day;
- Amoxicillin 1000 mg twice a day;
- Clarithromycin 500 mg twice daily.
The duration of the course of treatment is 7 – 14 days.
- De-Nol 1 tablet 2 times a day;
- Metronidazole 500 mg 3 times a day;
- Tetracycline 500 mg 4 times a day.
The course of treatment is 1 – 2 weeks.
Side effects
When taking De-Nol, the following side effects may occur:
- Abnormal stool (or);
- in black;
- Skin rash;
- Hives.
Contraindications
- Hypersensitivity to the active substance or auxiliary components;
- Severe renal dysfunction;
- Pregnancy and lactation;
- Children under 14 years of age.
Special instructions and interactions with drugs
To avoid toxic effects on the fetus, the drug is not prescribed to pregnant women. Breastfeeding must be stopped during treatment.
In case of overdose, it is necessary to perform gastric lavage and take enterosorbents.
Also in this case, symptomatic therapy is used. In case of severe renal impairment, hemodialysis is necessary.
The drug should not be taken simultaneously with other medications containing bismuth. When used simultaneously with antacid drugs, the rate of absorption of De-Nol is impaired.
Analogs
Analogues of De-Nol are Vis-Nol and Gastro-Norm.
De-Nol is a new generation antibiotic that has an antiulcer, anti-inflammatory effect with bactericidal activity against Helicobacter pylori.
It also has anti-inflammatory, antacid and astringent effects. Forms an insoluble protective coating at the site of the ulcer. Improves the protective properties of the gastrointestinal mucosa. Increases mucus production, resistance of the mucous membrane to the effects of pepsin, hydrochloric acid and enzymes.
On this page you will find all the information about De-Nol: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used De-Nol. Would you like to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Antiulcer agent with bactericidal activity against.
Conditions for dispensing from pharmacies
Dispensed with a doctor's prescription.
Prices
How much does De-Nol cost? The average price in pharmacies is 580 rubles.
Release form and composition
One De-Nol tablet contains 120 mg of active substance. The main component (bismuth tripotassium dicitrate), after penetrating the stomach at the site of the lesion, forms a protective layer that prevents stomach acid from corroding the damaged mucous membrane.
Excipients of the drug:
- ammonium and potassium citrates;
- povidone K 30;
- polacriline potassium;
- magnesium stearate;
- corn starch;
- macrogol 6000;
- hydroxypropyl methylcellulose.
The drug is available in the form of film-coated tablets. In a blister of 32, 56 or 112 pcs.
Pharmacological effect
The antiulcer drug leads to direct death of microorganisms, i.e. has a bactericidal effect on the bacteria Helicobacter pylori. De-nol is also characterized by an astringent and anti-inflammatory effect. In acidic gastric contents, insoluble compounds of bismuth citrate and oxychloride are deposited on the mucous membrane. On the surface of erosive and ulcerative lesions, a protective film is formed in the form of chelate compounds with protein molecules.
Taking De-nol leads to stimulation of the activity of mechanisms that protect cells and increased resistance of the gastric mucosa to the negative effects of hydrochloric acid, the proteolytic enzyme pepsin, as well as enzymes and bile salts. These effects are due to the activation of the synthesis of prostaglandin E, bicarbonate and mucus.
During treatment, the activity of the proenzyme pepsinogen and the enzyme pepsin decreases.
Indications for use
The drug De-Nol is excellent in treating many problems of the gastrointestinal tract:
- , as well as at ;
- Taking De-Nol also helps, regardless of whether the disease is in a chronic or acute form;
- It also treats the consequences of taking it.
A correctly prescribed course helps you forget about these diseases of the stomach and intestines, as well as the symptoms that accompany them.
Contraindications
The main contraindications for treatment with De-Nol include the following conditions:
- individual immunity to the drug or intolerance to it;
- pregnancy and breastfeeding;
- impaired renal function, including decompensated renal failure;
- liver dysfunction;
- children's age (up to 4 years).
Use during pregnancy and lactation
Contraindicated during pregnancy. It should also be avoided in breastfeeding women.
Instructions for use
The instructions for use indicate that the daily dose of the drug De-Nol and the duration of the course of therapy must be determined by the doctor. This depends on the patient’s body weight, age, severity of the pathological process, the presence of complications and individual tolerance to the drug.
Average dosages:
- Adults and children over 4 years old - orally 2-4 times a day 30 minutes before meals. The dose depends on the patient's age.
- The course of treatment is 4-8 weeks. You should not take medications containing bismuth for the next 8 weeks.
When eradicating H.pilory, the drug is prescribed in combination with other antibacterial agents that are active against this microorganism.
Side effects
Nausea, vomiting, more frequent bowel movements, diarrhea. With long-term use of the drug in high doses, encephalopathy is associated with the accumulation of bismuth in the central nervous system.
Overdose
When using the drug for a long time in increased dosages, there is a possibility of an overdose of the drug, which can cause kidney problems. In cases of drug overdose, the patient's stomach is washed out and activated charcoal is given in combination with saline laxatives. After these measures, symptomatic treatment is carried out.
For 30 minutes before and after taking the drug, you should not take any other medications, and during this time you should refrain from eating and drinking liquids (especially milk and fruit juices). When taking De-Nol tablets, stool may turn dark (this is due to the formation of bismuth sulfide). Some patients may experience mild darkening of the tongue while taking the drug.
special instructions
- During treatment, stool turns black.
- Simultaneous intake of De-Nol with food, milk, fruits, juices reduces its effectiveness.
- To enhance the bactericidal effect against Helicobacter pylori, in some cases it is advisable to combine with metronidazole and/or amoxicillin for 1-2 weeks.
Drug interactions
If you take other medicines at the same time, as well as food and liquids, in particular antacids, milk, fruit and fruit juices, the effectiveness of bismuth tripotassium dicitrate may change.
De-Nol is a modern medicine that can quickly eliminate ulcerative lesions on the walls of the gastrointestinal tract. A course of taking a pharmacological drug reduces the severity of pain, normalizes digestion and peristalsis. De-Nol exhibits bactericidal activity against spiral-shaped pathogenic bacteria Helicobacter pylori. This ability allows the drug to be used in the treatment of gastritis caused by microorganisms. Before taking De-Nol, you need to consult a doctor to make a diagnosis, prescribe a single and daily dose, and determine the duration of treatment.
De-Nol is taken to treat ulcers and various types of gastritis
Characteristics of taking the drug
The active ingredient of De-Nol is . The presence of this inorganic compound in the tablets determines the wide therapeutic spectrum of the antiulcer agent. Manufacturers used as auxiliary ingredients:
- corn starch;
- macrogol;
- magnesium stearate;
- potassium polyacrylate.
These components are necessary not only for the formation of tablets, but also for enhancing the medicinal properties of bismuth tripotassium dicitrate. They contribute to the optimal distribution of the active substance on the gastric mucosa and its gradual release. Despite its bactericidal activity, De-Nol does not belong to the group of antibiotics, since the destruction of Helicobacter pylori is only one of its beneficial properties for the gastrointestinal tract. Bismuth tripotassium dicitrate exhibits powerful anti-inflammatory, astringent and regenerating effects.
A wide spectrum of action allows you to combine De-Nol with drugs from various groups:
- with the latest generation antibiotics for laboratory diagnosis of Helicobacter pylori;
- with proton pump inhibitors when increased production of caustic hydrochloric acid and digestive enzymes by glandular cells is detected.
The therapeutic activity and duration of course treatment depend on what De-Nol is taken with. Taking antibiotics rarely takes more than 2-3 weeks, and proton pump inhibitors (Pantoprazole, Pariet) require longer use.
What is the use of the drug based on?
You need to take the medicine half an hour before meals. This promotes complete absorption of the active substance and the manifestation of the maximum therapeutic effect. Having penetrated the digestive tract, De-Nol, under the influence of gastric juice, is converted into inorganic bismuth salts and begins to bind to proteins. After the formation of high-molecular conglomerates, a durable film is formed on the surface of the mucous membrane.
This protective barrier prevents the negative effects of hydrochloric acid and pepsin on areas with erosions and ulcerative lesions. Taking De-Nol before meals, a person relieves pain and possible dyspeptic symptoms from eating food. What other beneficial properties does the drug have:
- accelerates the healing of mucous membranes;
- reduces the production of hydrochloric acid;
- reduces the functional activity of gastric juice.
The durable film formed under the influence of De-Nol does not allow pathogenic bacteria to attach to the walls of the stomach and move freely in the digestive organs.
Recommendation: “During treatment with De-Nol, you should limit the consumption of dairy products, or better yet, completely eliminate them from your diet. This will help avoid the development of side effects - increased gas formation, nausea, bloating.”
Bismuth tripotassium dicitrate helps reduce the enzymatic activity of Helicobacter pylori. Gram-negative bacteria lose their ability to grow and reproduce. The regimen for taking De-Nol with antibiotics is based on the inability of microorganisms to develop resistance to the antiulcer agent. This distinguishes it favorably from antibacterial drugs.
De-Nol tablets should be taken with plenty of still water.
Instructions for use
Taking medication without a prescription from a gastroenterologist is not only inappropriate, but also dangerous. Like all pharmacological drugs, De-Nol has its contraindications and side effects. It is prescribed to young children very rarely, and is taken under the supervision of a doctor. A large number of contraindications depend on how De-Nol should be taken - before or after meals. Taking pills on an empty stomach is an indispensable condition for proper therapy, but it also causes the development of some side effects.
The dosage of the drug is determined by the doctor after deciphering the results of laboratory tests. If De-Nol is used to destroy pathogenic microbes, then the amount of bismuth tripotassium dicitrate varies depending on the bactericidal effect of the antibiotics. For the treatment of ulcerative lesions not caused by Helicobacter pylori, high dosages are required with the following frequency of administration:
- the patient takes tablets twice a day with an interval of 8-10 hours;
- The daily dose is used immediately before breakfast.
For young children, the amount of the drug is calculated according to the child’s weight and divided into two doses. The tablets must not be chewed or dissolved in water. This will reduce therapeutic effectiveness and greatly delay recovery. A person’s well-being improves 10-14 days after the start of treatment.
Advice: “Gastroenterologists recommend that patients give up bad habits during treatment for ulcers and gastritis. Smoking will cause the drug to be less effective, and drinking alcohol will contribute to the development of side effects.”
Following a gentle therapeutic diet will help to quickly eliminate symptoms when taking De-Nol. The patient should exclude from his diet fatty, fried, spice-rich foods that irritate the mucous membranes of the gastrointestinal tract.
While taking De-Nol, you should avoid consuming dairy products.
Therapeutic regimens
- gastritis occurring against the background of increased production of hydrochloric acid;
- stomach and duodenal ulcers;
- inflammation of the duodenal mucosa and pyloric zone of the stomach;
- dyspeptic disorders of various etiologies;
- intestinal dyskinesia accompanied by diarrhea.
How to take a drug with proton pump inhibitors
Despite De-Nol's ability to reduce the acidity of gastric juice, in some cases the use of drugs with a stronger effect is required. These include proton pump inhibitors:
- Omeprazole and its analogues Omez, Ultop;
- Pantoprazole;
- Rabeprazole.
These drugs reduce the production of hydrochloric acid by glandular cells. When combining Omeprazole with De-Nol, the antisecretory activity of the drugs is enhanced, and the regeneration of damaged tissue is significantly accelerated. Gastroenterologists often include antibacterial drugs in this therapeutic regimen. How often you can take De-Nol with antibiotics to prevent relapses, the doctor conducting the treatment will tell you after assessing the frequency of exacerbations and the severity of their symptoms.
After taking proton pump inhibitors, the maximum concentration of active substances in the bloodstream is detected after a few hours, and the therapeutic effect continues throughout the day. Therefore, Omeprazole, Pantoprazole and Rabeprazole should be taken once a day. The drugs are indicated for use by patients not only with high but also with low acidity. This is necessary to better protect the gastric mucosa from hydrochloric acid.
How to take medicine with antibiotics
To treat ulcers and gastritis, only broad-spectrum antibiotics are used. In the process of laboratory research, in addition to the type of pathogenic pathogen, its sensitivity to certain antibacterial drugs is determined. Most often, gastroenterologists prescribe a therapeutic combination of Amoxicillin and Clarithromycin. If, after repeated tests, such a scheme turns out to be ineffective, then it is supplemented.
Warning: “Before drinking De-Nol, the patient is examined for the presence of cancerous tumors that can cause increased acidity of gastric juice.” In addition to antibiotics and De-Nol, the antimicrobial drug Metronidazole is used in the treatment of ulcers and gastritis.
Treatment with antibacterial agents is not complete without taking probiotics and prebiotics:
- Lactobacterin;
- Bifidumbacterin;
- Linux.
If De-Nol is used in combination with cephalosporins, Amoxicillin or Clarithromycin, then it should be taken simultaneously