Mildronate for cerebrovascular accidents. Mildronate: description, indications for use, general properties and effect

Instructions for use:

Mildronate is a synthetic drug that improves energy supply and tissue metabolism.

pharmachologic effect

The active ingredient Mildronate improves metabolism, promotes the removal of accumulated toxins from cells, has a tonic effect and protects cells from damage.

As a result of the use of Mildronate, the ability to withstand stress and quickly recover from it increases. Thanks to these properties, the drug is used to improve blood supply to the brain and treat various disorders of the cardiovascular system, as well as improve performance.

In case of heart failure, Mildronate, according to the instructions, increases myocardial contractility, reduces the frequency of angina attacks, while increasing tolerance to physical activity.

For ischemic cerebrovascular accidents, Mildronate is used to improve blood circulation in the ischemic area, which promotes blood redistribution.

Also, according to reviews, Mildronate is effective for disorders of the nervous system with withdrawal syndrome and pathology of the fundus.

Release form

Mildronate is available in the form:

• A colorless transparent solution, 1 ml of the drug contains 100 mg of the active substance - meldonium. In ampoules of 5 ml;
• White gelatin capsules containing the active substance in the form of crystalline powder with a slight odor. 250 or 500 mg of active ingredient per capsule, 10 pieces per blister.

Indications for use of Mildronate

Mildronate is indicated for use in complex therapy:

• For coronary heart disease, including myocardial infarction and angina, as well as for heart failure and dyshormonal cardiomyopathy;
• For strokes and cerebrovascular insufficiency.

Mildronate is also used for:

• Reduced performance;
• Retinopathy of various etiologies, including diabetic and hypertensive;
• Hemophthalmia and retinal hemorrhages of various etiologies;
• Physical overstrain;
• Thrombosis of the central retinal vein and its branches;
• Withdrawal syndrome in chronic alcoholism, in combination with specific therapy.

What properties of the body can the drug enhance? What diseases can it prevent/cure? Meldonium does not enhance any properties of the body; it helps the body's cells during ischemia to more effectively fight the lack of oxygen, as well as protect them from the destructive effects of substances that are formed from long-chain fatty acids during ischemia. Due to its unique mechanism of action, meldonium as a second-line drug, that is, as an additional therapy to the main one, is used to treat cardiovascular diseases, is used to restore performance and reduces symptoms of mental and physical stress.

Contraindications

According to the instructions, Mildronate is contraindicated for use in children under 18 years of age, with hypersensitivity to the drug, as well as with increased intracranial pressure, including intracranial tumors and disorders of venous outflow.

Reliable studies on the use of Mildronate during pregnancy and lactation have not been conducted, as a result of which the drug is not recommended for use during these periods.

Mildronate is used with caution, especially for a long time, in case of liver or kidney diseases.

Instructions for use of Mildronate

The dose and route of administration of Mildronate depend on the disease:

• For cardialgia developing against the background of dyshormonal myocardial dystrophy, Mildronate is taken twice a day for 12 days, 250 mg;
• For cardiovascular diseases, Mildronate is indicated as part of complex therapy, up to 2 times a day, 0.5-1 g. Treatment is usually carried out from a month to 6 weeks;
• For chronic cerebrovascular accidents, take 1-2 tablets of Mildronate (500 mg each) per day for a course of 4 to 6 weeks. According to indications, treatment can be performed several times a year;
• In the acute phase of cerebrovascular accident, Mildronate is administered intravenously for 10 days, 500 mg once a day, according to instructions. After this, you can switch to taking Mildronate tablets, 0.5-1 g per day. The general course of therapy is usually up to 6 weeks;
• For increased mental or physical stress, take 1 tablet of Mildronate 250 mg, up to 4 times a day for two weeks. A repeat course can be completed no earlier than 2 weeks later.

Athletes are recommended to use Mildronate before training, twice a day, 0.5-1 g. During the preparatory period, the drug - from two to three weeks, during competitions - 2 weeks.

For disorders caused by chronic alcoholism, usually take 1 tablet of Mildronate (500 mg) 4 times a day for 10 days.

Mildronate is indicated for use in the first half of the day due to the possibility of developing an stimulating effect.

Side effects

According to reviews, Mildronate is a low-toxic drug and does not cause side effects hazardous to health. Extremely rarely:

• Changes in blood pressure;
• Tachycardia;
• Dyspeptic symptoms;
• Psychomotor agitation.

Also, according to reviews, Mildronate can cause allergic reactions in the form of swelling, rash, redness or itching of the skin.

Caution should be exercised when used simultaneously with certain antianginal and antihypertensive drugs, as well as cardiac glycosides, since Mildronate enhances their effect.

When used simultaneously with Mildronate, antihypertensive drugs, nifedipine, nitroglycerin, peripheral vasodilators and alpha-blockers may develop moderate tachycardia and arterial hypotension.

Mildronate can be taken with anticoagulants and antiplatelet agents, as well as diuretics and antiarrhythmics.

Of particular note is the safety of using the drug Mildronate; this is one of the important factors explaining its wide acceptance among doctors and patients. The safety of Mildronate is confirmed by periodically updated safety reports and the results of published clinical studies.

After Latvia joined the European Union, it became a mandatory requirement of regulatory authorities to have a Pharmacovigilance system responsible for monitoring and evaluating the use of medicines. Since the beginning of monitoring (since March 21, 2006), Grindeks JSC has received 478 spontaneous reports (messages) about products containing meldonium. No potential significant health risk was identified in these cases. There have been no reports of the development of dependence or addiction to the drug after its use. There were no reports of adverse events or reactions from athletes.

Storage conditions

Mildronate is available with a prescription. The shelf life of injection solution and tablets is 4 years.

It is also prescribed for the treatment of certain ophthalmological pathologies, increasing endurance, both physical and intellectual.

There are several forms of release of Mildronate, each of which can be prescribed based on the severity of symptoms, the patient's condition or his personal preferences. Doctors usually prescribe Mildronate injections in cases where it is necessary to quickly achieve a therapeutic effect or if the patient cannot take pills. Usually, the course of treatment can be continued in the future, switching from the injection to the oral form of the drug.

Description of the active substance

According to the instructions for use of Mildronate, the active ingredient in its composition is meldonium or trimethylhydrazinium propionate dihydrate. In structure, it is an analogue of gamma-butyrobetaine, which is present in all human cells. The mechanism of action of meldonium is to block the production of carnitine, as a result of which the synthesis of gamma-butyrobetaine increases. It promotes vasodilation and more efficient blood supply to tissues, especially those under hypoxic conditions.

The drug protects cells from the aggressive effects of catabolic products and toxins, accelerating the elimination of these agents from the body. With ischemia of tissues and organs (for example, myocardium, brain, retina), meldonium changes the blood flow ratio in favor of areas with hypoxia. Thus, its anti-ischemic and antihypoxic effect is manifested.

In conditions of acute lack of myocardial blood circulation, Mildronate helps slow down the formation of necrotic damage and shortens the rehabilitation period. For angina pectoris, the drug reduces the number of attacks of anginal pain and increases cardiac output. Thanks to it, the stimulation of neurons increases, the motor sphere and physical endurance are activated. It also has an anti-stress effect.

Meldonium improves the course of the rehabilitation period in patients who have suffered vascular, inflammatory diseases of the brain or had injuries to the central nervous system. It reduces movement disorders (paresis), improves coordination, and reduces the severity of vegetative manifestations. The use of the drug helps improve the condition of patients with alcohol dependence and reduces the manifestations of withdrawal syndrome.

Pharmacokinetics

The maximum plasma concentration of Mildronate for injection is achieved almost immediately after its parenteral administration. It is quickly distributed in tissues and binds to blood plasma proteins. The bioavailability of the drug is 100%.

Attention! The drug partially penetrates the hematoplacental barrier, and has also been found to pass into breast milk.

Metabolism of Mildronate occurs in the liver

The drug and its metabolites are excreted primarily by the kidneys. The half-life is 3-6 hours.

Indications

What is Mildronate used for, and when can it be useful? Indications for the use of the drug are the following pathological conditions:

• cardiovascular pathology: chronic ischemic heart disease, angina pectoris, myocardial infarction, chronic heart failure;
• dishormonal cardiomyopathy;
• vegetative-vascular dystonia;
• chronic circulatory disorders in the brain;
• cerebral stroke;
• pathology of peripheral arterial vessels;
• postoperative recovery period;
• bronchial asthma and chronic obstructive pulmonary disease as a component of complex treatment;
• eye diseases of various origins: hemorrhage in the retina and vitreous body of the eye, retinopathy (hypertensive and diabetic), thrombosis of the central retinal vein, impaired blood supply to the retina.
• chronic alcoholism and withdrawal syndrome in alcohol addicts in combination with other types of treatment;
• high physical fatigue and overstrain;
• low productivity of physical and intellectual labor.

Attention! For diseases of the organ of vision, the use of Mildronate injections only parabulbarly is indicated.

In case of cardiovascular pathology, Mildronate injections are part of the complex therapy of these diseases and cannot replace constant treatment with basic drugs

Among the indications for the use of Mildronate, sports training has also found its niche in order to increase endurance, for quick recovery after hard and long-term sports.

How to take the drug?

Mildronate solution has a meldonium concentration of 10%. It is produced in ampoules of 5 ml. Accordingly, 1 ml of solution contains 100 mg of meldonium, and one ampoule contains 500 mg. The box contains 10 ampoules. The drug is prescribed 1 or 2 times a day. The drug solution can be administered in several ways:

• intramuscularly;
• intravenously;
• parabulbar (near the eyeball).

Mildronate is usually administered intravenously in a jet manner, this way the desired effect can be achieved faster. If there is no urgent need for immediate action of the drug, then it can be injected into a vein using a dropper.

The drug in the form of a solution does not need to be diluted before administration.

Mildronate solution is available in a sufficient concentration of the active substance and does not require additional dilution. This applies to all methods of injection delivery of the drug. However, doctors may prescribe its administration, for example, with saline solution. If Mildronate is nevertheless diluted, then the absolute amount of the active substance will not change, only its concentration will decrease, which may affect the speed of onset of the drug’s effect.

In cases where rapid action is not required, Mildronate can be diluted. For this purpose only, it is better to use a 0.9% sodium chloride solution (saline). Mixing with other solvents may affect the properties of the drug, which is extremely undesirable.

Mildronate activates nervous activity, so it should be taken at least 4-6 hours before bedtime. Otherwise, sleep disturbance in the form of insomnia may occur. The daily dose can be taken in one injection or divided into two doses.

Dosage for various pathologies

The dose of the drug depends on the specific disease and is selected by the doctor individually:

• Unstable angina and myocardial infarction. In such cases, intravenous administration of the drug is indicated, since these conditions are acute and require immediate intervention. 5-10 ml of Mildronate are administered intravenously. If injections are poorly tolerated, the entire dose is administered once; in other cases, dividing it into two injections is indicated. The duration of parenteral administration of drugs ranges from 1 to 10 days. In the future, you can switch to oral forms of Mildronate and take it in a general course lasting up to 4-6 weeks.
• Chronic circulatory failure. Use 5-10 ml IV once a day or 5 ml twice a day IM. The course lasts up to 2 weeks with a transition to syrup or tablets.
• Ophthalmological pathology. In this case, Mildronate is used parabulbarly at 0.5 ml per day (50 mg meldonium) for 10 days.
• Brain stroke in the acute phase. To achieve a quick effect from the use of the drug, it is administered intravenously at a dose of 5 ml per day for 10 days. You can also inject it intramuscularly at a dose of 500 mg once a day for 2-3 weeks.
• Chronic cerebrovascular insufficiency. For this pathology, the drug is administered either intramuscularly or in tablet form. Inject 5 ml of solution intramuscularly 1 time for 14 days. Reception is extended if necessary up to 4 weeks.
• Dyshormonal cardiomyopathy. Apply 5-10 ml intravenously in one injection per day or 5 ml intramuscularly 2 times a day. The course is 14 days, and if oral administration is continued, it is recommended to take Mildronate for another 2 weeks.
• Chronic alcoholism. Patients receive Mildronate intravenously, 5 ml 2 times a day to relieve neurological symptoms. Continue therapy for up to one week.
• Increased fatigue during periods of high physical and intellectual stress. There is no urgent need for parenteral administration of Mildronate for such indications, but it all depends on which method is more acceptable to the patient and how quickly the effect is expected. The drug is taken intramuscularly, 1 ampoule 1 or 2 times a day. It is also possible to take Mildronate intravenously in a similar dosage regimen. The course of treatment is up to 2 weeks. If there is a need, it can be repeated after another 2-3 weeks.

If, in chronic cerebrovascular accidents, there are swallowing disorders or digestive problems, you should choose the parenteral route of administration of Mildronate

Interaction

Mildronate, interacting with other drugs, can cause both desirable and dangerous reactions in the body. Many patients are interested in whether it is possible to combine meldonium with other drugs. Only a doctor can give a definite answer to this question.

Meldonium increases efficiency:

• antiplatelet agents;
• anticoagulants;
• bronchodilators;
• antiarrhythmics;
• antianginal drugs;
• diuretics.

When prescribing Mildronate, always warn your doctor about taking any medications and about concomitant diseases.

The drug potentiates the effect of beta blockers and cardiac glycosides. Particular caution should be taken when taking Mildronate with the following drugs:

• alpha blockers;
• nitrates;
• calcium channel antagonists;
• peripheral vasodilators.

Taking these drugs together can lead to a sharp decrease in blood pressure and tachycardia.

Contraindications

According to the instructions for use of the drug, it is not prescribed in the following cases:

• pregnancy;
• lactation period;
• children under 12 years of age;
• allergy or the presence of individual hypersensitivity to meldonium.

Side effects and drug overdose

Typically, patients experience a high degree of tolerability of the drug, but sometimes there are cases of adverse reactions to Mildronate:

• skin allergic manifestations in the form of rash, urticaria, rarely - angioedema;
• dyspepsia;
• fluctuations in blood pressure;
• increased heart rate;
• insomnia and psychomotor agitation;
• weakness;
• change in blood count (increased level of eosinophils).

special instructions

In patients who have serious kidney and liver diseases with insufficiency of the functions of these organs, biochemical blood parameters should be monitored. If long-term use of meldonium is necessary, consultation with the attending physician is required to adjust the dose of the drug.

A person taking Mildronate may be allowed to drive vehicles and operate machinery, since the drug does not cause a slowdown in reactions. Elderly patients should reduce the therapeutically effective daily dose.

Application in sports

Due to Mildronate's ability to increase the absorption of oxygen by tissues, it can be recommended for increasing tolerance to physical activity. It improves nutrition of the myocardium and peripheral muscles. This helps reduce fatigue and speed up recovery after training.

Until recently, meldonium was not considered doping, but since 2016 it has been included in the list of drugs that are considered doping in sports

Storage conditions

After opening the ampoule, the solution cannot be stored under any circumstances. A refrigerator is also not suitable for this purpose. After 20 minutes or more have passed after the seal has been broken, the ampoule should be discarded.

Reviews of Mildronate

Patient reviews of this drug are mostly positive. Doctors' opinions on Mildronate are somewhat different.

On the other hand, there are supporters of Mildronate therapy who note the high effectiveness of the drug in their patients.

Since there is almost no evidence base for the drug Mildronate, its effect is equivalent to the placebo effect

I took Mildronate to improve my performance during exams at the institute. I can only say good things: the drug greatly helps overcome fatigue and improve memorization of material. I could stay awake for a long time and still feel relatively alert. Its action is similar to that of an energy drink, only without the side effects.

Valentina, 58 years old

The doctor advised me to take Mildronate after an increase in angina attacks. At first I received intravenous injections for a week, then I drank syrup for another 3 weeks. During this period, the attacks of pain stopped, there was almost no shortness of breath.

Irina, 42 years old, cardiologist

Mildronate increases exercise tolerance in patients with coronary artery disease. It has a good effect on the well-being of patients with vegetative-vascular dystonia. During therapy with the drug, the symptoms regress completely, but a course of treatment is required, which should be repeated from time to time.

Is it possible to inject Mildronate intramuscularly and intravenously?

Mildronate is a metabolic medicine designed to restore the balance of oxygen inside cells and quickly restore energy reserves. To the question - can Mildronate be injected intramuscularly, the instructions supplied with the drug give the answer. In it, the manufacturer claims that the medication solution is intended for intravenous, intramuscular and parabulbar administration.

Indications

Mildronate is administered intravenously for:

• chronic heart failure;
• cardiomyopathy;
• retinal thrombosis;
• cerebrovascular insufficiency;
• retinopathy.

The drug is indicated to increase performance and maintain the body during severe physical and mental stress. The active components of this medication may be of interest to all heart patients and post-stroke patients. The medicine contains meldonium, which supports the functioning of the heart and brain in the body. Thanks to its effects, the patient’s performance improves and the neurological functions of the body improve.

How does the medicine work?

After entering the blood and tissues, the components of the drug reach their maximum concentration in the blood plasma. The medication increases heart contractions, supports myocardial function, and improves cerebral circulation. Mildronate can be injected intramuscularly to redistribute blood masses during ischemia. As a result of treatment, the concentration of carnitine stabilizes and the formation of necrotic areas slows down.

From the bloodstream, the active substances of the product are distributed throughout the cellular structures of the tissue.

• improve the functionality of the central nervous system;
• relieve paresis;
• improve the body's reflexes.

Mildronate, when administered intramuscularly, has a beneficial effect on the entire nervous system.

Mildronate injections intramuscularly reduce the body's rehabilitation for various heart diseases several times. The active substances of the drug enhance the synthesis of butyrobetaine, which has a vasodilating effect. The drug improves the functioning of brain structures, blood supply to the brain, and increases physical performance.

The drug eliminates functional disorders in chronic alcoholism and eliminates angina attacks. As a result of treatment, heart function stabilizes. The medication is advisable to use in the treatment of stroke and heart disease.

Methods of drug administration

Intravenously

Injection of Mildronate solution when administered intravenously does not cause adverse reactions. The medicine is well tolerated by the body. However, when administered intramuscularly, the active substances of the drug are absorbed more slowly. This feature should definitely be taken into account if Mildronate is injected intramuscularly.

Parabulbar method of administration

The parabulbar method of administering the solution is that the injection is made into the lower eyelid. This method of drug administration is used in ophthalmic practice. The needle is directed into the eyeball located near the fiber. The injection is quite painful. The medicinal solution must be administered very carefully.

Intramuscularly

Intramuscular administration of the drug can be replaced by taking capsules and tablets. One tablet of the product contains 250 mg of meldonium dihydrate. The active substance has a metabolic effect. You need to take the drug per day at a dose of 500 mg - that’s two capsules per day. The daily dose is divided into two doses or taken once if necessary.

The drug Mildronate is administered intramuscularly to many patients suffering from heart failure. The price of medication, on average, varies between 665 rubles.

Found a mistake? Select it and press Ctrl + Enter

Can mildronate be administered intramuscularly?

Mildronate can be called a kind of universal fighter: this drug is prescribed for a variety of ailments. Its active substance, meldonium, accelerates intercellular metabolism, helping the body cope with many ailments and recover from serious stress.

The instructions for use say: the drug can be taken orally - in the form of capsules, or, if injections are not scary, it can be injected intravenously - then ask pharmacists for it in ampoules. But is it permissible to administer mildronate intramuscularly?

Mildronate: one answer to a thousand troubles

The scope of action of this medicine is indeed wide.

The instructions for use of mildronate state that it is necessary for:

• speedy recovery after heavy physical and mental stress;
• oxygen saturation of cells;
• creating a barrier to toxins that accumulate in cells;
• toning the whole body;
• increasing the frequency of myocardial contractions;
• improving blood circulation;
• elimination of nervous system disorders, especially with long-term alcoholism;
• strengthening muscles.

That is why there are a lot of diagnoses for which doctors prescribe mildronate:

• chronic heart failure;
• acute ischemia;
• angina pectoris, myocardial infarction;
• circulatory disorders.

It is also often offered for reduced performance, rapid fatigue, and constant mental and physical stress.

It is noteworthy that the active ingredient of the drug, meldonium, has the same structure as a substance with the complex name gamma-butyrobetain, which can be found in every cell of our body. If there is a shortage of it, it is recommended to administer mildronate. According to the instructions for use, any analogue of mildronate has similar properties, of which, by the way, there are many in pharmacies: melfor, vasomag, medatern, idrinol...

Why do bodybuilders need mildronate?

What is metabolism?

The properties of the drug, which play into the hands of athletes, are really useful. Mildronate:

• ensures oxygen delivery to all cells;
• prevents the accumulation of saturated fatty acids in cells;
• helps to better nourish muscles;
• relieves tension, accumulated fatigue, increases performance;
• serves as a guarantee of training effectiveness;
• protects the heart from increased stress.

It is also interesting that thanks to the drug, you can restore the body in a much shorter time, make it stronger, and therefore get much better results.

Dosage of the drug

Mildronate is produced in capsules or ampoules. Swallowing or injecting is a personal choice, and yet, according to some studies, if the drug is injected intravenously, its effectiveness increases by about 2 times. That is why the instructions for use devote a lot of space to indicating the dosage of the medicine: it varies not only for different diseases, but also when using different dosage forms.

For example, athletes take 0.5–1 gram of medication orally twice a day. The course of admission is 3 weeks during preparation for competitions and 10–14 days during the active period of sports achievements and achievements.

During mental and physical stress, you can administer 250 mg of the medicine as much as 4 times a day! Injecting veins so often, especially since the course of treatment lasts 12 days, you must agree, is still a test. Therefore, it is better to take it in capsule form.

But for cardiovascular diseases, you will need to administer mildronate intravenously - 1 gram of the active substance twice a day. You will have to be patient: the course of treatment lasts 4–6 weeks.

Can the drug be administered intramuscularly? The instructions for use compiled by the manufacturer do not provide for this method of use. And doctors themselves are wary of this idea. Firstly, the effectiveness of the drug is significantly reduced. In addition, many manufacturers warn that medicine administered intramuscularly can cause allergies, and such an injection itself can be called very painful. Therefore, it is better to abandon the idea of ​​​​doing an intramuscular injection: the game is not worth the candle.

Contraindications and side effects

Despite its tempting properties, injections of mildronate must be done with great caution: it is known to cause side effects. Among them are muscle agitation, rapid heartbeat, itching, rash and redness on the skin, swelling at the injection site. If at least one of the side effects manifests itself, this is a serious reason to stop taking the drug and consult a doctor.

In addition, it has many contraindications.

• increased intracranial pressure;
• chronic kidney and liver diseases;
• age under 18 years;
• period of pregnancy and breastfeeding.

In a separate line, manufacturers warn against taking the medicine while drinking alcohol. Remember: mildronate and alcohol are completely incompatible!

Mildronate (Meldonium - tablets, capsules, syrup, injections) – indications, instructions for use, analogues, reviews, price

Names, release forms, composition and dosages of Mildronate

1. Capsules for oral administration;

2. Syrup for oral administration;

3. Solution for injection (intramuscular, intravenous and parabulbar).

• Methyl parahydroxybenzoate;
• Propyl parahydroxybenzoate;
• Propylene glycol;
• Sorbitol;
• Glycerol;
• Citric acid monohydrate;
• Cherry essence;
• Allura Red dye (E129);
• DyeBrilliant Black BN (E151);
• Purified water.

Capsules are available in two dosages - 250 mg and 500 mg of meldonium. The syrup contains 250 mg of meldonium per 5 ml, that is, it has a concentration of 50 mg/ml. And the injection solution contains 100 mg of meldonium in 1 ml (100 mg/ml).

Therapeutic effect of Mildronate

• Cardioprotective effect– protecting heart cells from negative influences and improving their viability;
• Antianginal action– reduction in the oxygen needs of myocardial cells (due to this effect, myocardial cells have enough of even a small amount of oxygen supplied under ischemic conditions, which reduces the severity of pain, reduces the frequency of angina attacks and increases the tolerance of physical and emotional stress);
• Antihypoxic effect– reducing the negative impact of oxygen deficiency;
• Angioprotective effect– protection and ensuring the integrity of the walls of blood vessels;
• Tonic effect.

In addition, Mildronate dilates blood vessels and normalizes cellular immunity, which increases the body's resistance to viral infections.

Mildronate - indications for use

• Coronary heart disease (as part of complex treatment);
• Angina pectoris (as part of complex treatment);
• Myocardial infarction (as part of complex treatment);
• Chronic heart failure;
• Pain in the heart due to myocardial dystrophy;
• Dyshormonal cardiomyopathy (myocardial dystrophy);
• Functional disorders of the cardiovascular system in adolescents;
• Myocardial dystrophy in adolescents;
• Neurocirculatory dystonia in adolescents;
• Acute and chronic cerebral circulatory disorders (stroke, cerebrovascular insufficiency);
• Poor blood circulation in the retina;
• Hemophthalmos (injection solution only);
• Hemorrhages in the retina (injection solution only);
• Thrombosis of the central retinal vein or its branches (injection solution only);
• Diabetic and hypertensive retinopathy (injection solution only);
• Bronchial asthma (as part of complex therapy);
• Chronic bronchitis (as part of complex therapy);
• Alcohol withdrawal (as part of complex treatment);
• Chronic alcoholism (as part of complex treatment);
• Low mental and physical performance;
• Physical stress and fatigue;
• The postoperative period after any surgical intervention.

• For quick recovery after high loads in training and competitions;
• Overtraining;
• Low performance.

Mildronate - instructions for use

Mildronate tablets (Mildronat 250, Mildronate 500) and syrup

• A teaspoon contains 5 ml of liquid;
• A dessert spoon contains 10 ml of liquid;
• A tablespoon contains 15 ml of liquid.

That is, you can simply take a spoon that holds the required amount of syrup and pour it into it.

250 mg in 5 ml (this is the concentration declared by the manufacturer);

X = 312.5 * 5/250 = 6.25 ml.

Mildronate injections - instructions for use

Dosages and rules for administering Mildronate intramuscularly and intravenously

special instructions

Impact on the ability to operate machinery

Overdose

Treatment of an overdose of Mildronate is only symptomatic, aimed at relieving painful symptoms and maintaining the normal functioning of vital organs.

Interaction with other drugs

• Antianginal agents (Sustak, Nitrong, Betalok, Cordanum, Trental, Dipyridamole, Riboxin, etc.);
• Anticoagulants (Warfarin, Thrombostop, etc.);
• Antiplatelet agents (Prostacyclin, Aspirin Cardio);
• Antiarrhythmic drugs (Adenokor, Amiodarone, Bretilate, Difenin, Cordarone, Moratsizin, Propanorm, Ritalmex, Rhythmiodarone, etc.);
• Diuretics (Veroshpiron, Diacarb, Furosemide, etc.);
• Bronchodilators (Ventolin, Berotek, etc.).

Mildronate should be combined with caution with Nitroglycerin, Nifedipine, alpha-blockers (Doxazosin, Setegis, Tulazin, etc.), antihypertensive drugs and peripheral vasodilators (Traklir, Naniprus, Cormagnesin, etc.), since there is a high risk of developing tachycardia and a sharp decrease in blood pressure.

Side effects

Contraindications for use

• Increased intracranial pressure (due to impaired venous outflow or in the presence of intracranial tumors);
• Pregnancy and breastfeeding (due to unproven complete safety);
• Hypersensitivity or allergic reactions to the components of the tablets, syrup or solution;
• Age under 12 years.

Some instructions for use indicate that Mildronate is contraindicated for children under 18 years of age, however, such terms are reinsurance on the part of the drug manufacturer.

Meldonium - analogues

• Angiocardil solution for injection;
• Vasomag capsules and solution for injection;
• Idrinol injection solution;
• Cardionate capsules and solution for injection;
• Meldonium capsules and solution for injection;
• Midolate capsules;
• Mildrakor solution for injection (only in Ukraine);
• Mildrocard capsules (only in Belarus);
• Melfor capsules;
• Medatern capsules.

The following drugs are analogues of Mildronate:

• Angiosil retard tablets;
• Antisten and Antisten MV tablets;
• Biosynth lyophilisate for the preparation of solution for injection;
• Bravadin tablets;
• Valeocor-Q10 tablets;
• Vero-Trimetazidine tablets;
• Histochrome solution for injection;
• Deprenorm MV tablets;
• Dibicor tablets;
• Dynaton solution for injection;
• Doppelhertz Cardiovital tablets;
• Ezaphosphine lyophilisate and ready solution;
• Inosie-F and Inosine-Eskom solution for injection;
• Carditrim tablets;
• Coraxan tablets;
• Coronatera pellets;
• Kudevita capsules;
• Kudesan drops;
• Medarum 20 and Medarum MV tablets;
• Mexicor capsules and solution for injection;
• Metagard tablets;
• Sodium adenosine triphosphate (ATP) solution for injection;
• Neoton lyophilisate for the preparation of solution for injection;
• Orocamag capsules;
• Pedea solution for injection;
• Predisin tablets;
• Preductal and Preductal MV tablets;
• Precard tablets;
• Ranexa tablets;
• Riboxin capsules, tablets and solution for injection;
• Rimecor and Rimecor MV tablets;
• Taufon tablets;
• Triducard tablets;
• Trimectal capsules;
• Trimectal MV tablets;
• Trimet tablets;
• Trimetazide tablets and capsules;
• Trimetazidine and Trimetazidine MB tablets;
• Trimitard MV tablets;
• Ubinon capsules;
• Firazir solution for injection;
• Phosphaden tablets and solution for injection;
• Ethoxydol tablets.

Mildronate - reviews

Reviews from cardiologists

Results of clinical studies of the drug Mildronate, comments from experts - video

What's better than Mildronate?

Mildronate (tablets, ampoules) – price

• Capsules 250 mg, 40 pieces – 243 – 308 rubles;
• Capsules 500 mg, 60 pieces – 561 – 712 rubles;
• Solution 10%, 10 ampoules of 5 ml – 303 – 391 rubles.

Mildronate for injection - official instructions for use

on medical use of the drug

Registration number:

Trade name of the drug

International nonproprietary name

Dosage form

Compound

active ingredient - meldonium dihydrate 100 mg;

excipient - water for injection.

Transparent colorless liquid.

Pharmacotherapeutic group

Pharmacological properties

Meldonium (Mildronate ®) is a structural analogue of gamma-butyrobetaine, a substance that is found in every cell of the human body.

Under conditions of increased stress, Mildronate ® restores the balance between the supply and need of cells for oxygen, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage; also has a tonic effect. As a result of its use, the body acquires the ability to withstand stress and quickly restore energy reserves. Thanks to these properties, Mildronate ® is used to treat various disorders of the cardiovascular system, blood supply to the brain, as well as to increase physical and mental performance. As a result of a decrease in carnitine concentration, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. In case of acute ischemic damage to the myocardium, Mildronate ® slows down the formation of the necrotic zone and shortens the rehabilitation period. In heart failure, it increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks. In acute and chronic ischemic disorders of cerebral circulation, Mildronate ® improves blood circulation in the ischemic area and promotes blood redistribution in favor of the ischemic area.

The drug eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal syndrome.

The bioavailability of the drug after intravenous administration is 100%. The maximum concentration in blood plasma is achieved immediately after its administration. Metabolized in the body to form two main metabolites, which are excreted by the kidneys. The half-life (T 1/2) is 3-6 hours.

Indications for use

Reduced performance; mental and physical overload (including among athletes).

Withdrawal syndrome in chronic alcoholism (in combination with specific therapy for alcoholism).

Contraindications

For liver and/or kidney diseases.

Use during pregnancy and breastfeeding

Directions for use and doses

The method of administration, dose and duration of treatment are determined individually, depending on the indications, severity of the condition, etc.

As part of complex therapy:

coronary heart disease (myocardial infarction) intravenously in a stream of 0.5-1.0 g per day (5-10 ml of the drug Mildronate ®), applying the entire dose at once or dividing it into 2 administrations;

coronary heart disease (stable angina); chronic heart failure and dishormonal cardiomyopathy intravenously in a stream of 0.5-1.0 g per day (5-10 ml of the drug Mildronate ®), applying the entire dose at once or dividing it into 2 injections, or intramuscularly at 0.5 g 1-2 times a day, a course of treatment of days, followed by transition to oral administration.

The general course of treatment is 4-6 weeks.

2. Cerebrovascular accident

As part of complex therapy in the acute phase, 0.5 g (5 ml of the drug Mildronate ®) 1 time per day intravenously for 10 days, switching to 0.5-1 g orally. The general course of treatment is weeks. For chronic cerebral circulatory failure (dyscirculatory encephalopathy), 0.5 g (5 ml of Mildronate ®) IM or IV once a day for 10 days, then 0.5 g orally. The general course of treatment is 4-6 weeks.

Repeated courses (usually 2-3 times a year) are possible after consultation with a doctor.

3. Ophthalmopathology (hemophthalmos and retinal hemorrhages of various etiologies, thrombosis of the central retinal vein and its branches, retinopathy of various etiologies (diabetic, hypertensive)).

0.05 g (0.5 ml of the drug Mildronate ®) parabulbarly for 10 days. It is also used as part of combination therapy.

4. Mental and physical overload

0.5 g (5 ml of Mildronate ®) IM or IV 1 time per day. Course of treatment days. If necessary, treatment is repeated after 2-3 weeks.

0.5 g (5 ml of Mildronate ®) IM or IV 2 times a day. Course of treatment days.

Side effect

Overdose

Mildronate ® is low-toxic and does not cause side effects dangerous to the health of patients.

Interaction with other drugs

Can be combined with antianginal drugs, anticoagulants, antiplatelet agents, antiarrhythmic drugs, diuretics, bronchodilators. Enhances the effect of cardiac glycosides.

Due to the possible development of moderate tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-blockers, other antihypertensive drugs and peripheral vasodilators, since Mildronate ® enhances their effect.

special instructions

Impact on the ability to drive vehicles and machinery

There is no data on the adverse effects of the drug Mildronate ® on the speed of psychomotor reaction.

Release form

5 ml in a clear glass ampoule with a line or break point.

5 ampoules in a cell package made of polyvinyl chloride film or uncoated polyethylene terephthalate film (pallet).

Two cell packaging (pallets) along with instructions for use in a cardboard pack.

Storage conditions

Keep out of the reach of children.

Best before date

Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies

Registration Certificate Holder

JSC "Grindeks" St. Krustpils 53, Riga, LV-1057, Latvia.

Manufacturer(s)

Elfa Pharmaceutical Company S.A. St. Vincentego Polya 21, Jelenia Gora, Poland

PJSC "Pharmstandard-UfaVITA", Russia., Republic of Bashkortostan, Ufa, st. Khudaiberdina, 28;

Organizations accepting complaints

Representative office in Moscow (in the production of the drug JSC Sanitas, Lithuania; Elfa Pharmaceutical Company S.A., Poland; HBM Pharma sr.o., Slovakia).

117556, Moscow, Varshavskoe highway, 74, bldg. 3rd, 5th floor,

PJSC "Pharmstandard-UfaVITA", Russia (in the production of the drug PJSC "Pharmstandard-UfaVITA", Russia)., Republic of Bashkortostan, Ufa, st. Khudayberdina, 28.

Mildronate

Description current as of 03/09/2016

• Latin name: Mildronate
• ATX code: C01EV
• Active ingredient: Meldonium
• Manufacturer: JSC “Grindeks”, Latvia

Compound

One hard gelatin capsule of Mildronate contains 250 or 500 mg of Meldonium in the form of dihydrate as an active component and excipients: Amylum solani (potato starch), Silicii dioxydum colloidale (colloidal silicon dioxide), Calcium stearate (calcium stearate).

To make the gelatin shell, Gelatinum (gelatin) and Titanium dioxyde (titanium dioxide) are used.

One milliliter of Mildronate injection solution contains 100 mg of Meldonium and water for injection as an auxiliary component.

One Mildronate tablet contains 500 mg of Meldonium in the form of phosphate and auxiliary components: Mannitum (E421; mannitol), Povidonum K-29/32 (povidone K-29/32), Amylum solani (potato starch), Silicii dioxydum (silicon dioxide) , Cellulose microcrystalline (microcrystalline cellulose), Magnesium stearate (magnesium stearate).

Release form

The drug Mildronate is produced by the manufacturer in the form:

• clear colorless solution for injection;
• hard gelatin capsules No. 1 and No. 2, filled with hygroscopic white crystalline powder. The powder contained in the capsules has a weak characteristic odor and a sweetish taste (the capsule itself has a neutral taste);
• tablets Mildronate Gx 500 mg (tablet taste slightly sour).

The solution is sold in 5 ml ampoules (500 mg/5 ml). One cardboard package contains: 2 blister packs with 5 ampoules of Mildronate in each and instructions for use of the drug.

Capsules are packaged in blisters of 10 pieces each. One cardboard box contains 4 blisters and instructions for use of the drug.

pharmachologic effect

Meldonium is a synthetic drug that has a similar effect to γ-butyrobetaine (GBB; a substance that is a precursor to hydroxytrimethylaminobutyric acid, a natural vitamin-like substance related to B vitamins).

According to Wikipedia, meldonium is characterized by its ability to improve metabolism and energy supply to cells and is used as:

The mechanism of action of Meldonium determines a wide range of its pharmacotherapeutic properties. Taking this drug helps improve performance, reduces the severity of manifestations of mental, intellectual and physical stress, and activates tissue and humoral immunity.

In patients suffering from heart failure, it increases the strength of contractions of the heart muscle, reduces the frequency of heart attacks (angina attacks), and also increases the body's tolerance to physical activity.

In case of acute myocardial damage, the use of Meldonium slows down the formation of necrotic zones, shortens the duration of the rehabilitation period, normalizes blood circulation in the area of ​​ischemic damage and redistributes blood in favor of the ischemic area.

Under conditions of increased stress, meldonium helps restore the balance between the transport of oxygen into cells and the cells' need for it, prevents the accumulation of cellular metabolic products and toxic substances in cells, protects cells and cellular structures from damage, ensures rapid compensation by the body of its energy reserves and maintains the highest speed metabolic processes.

By toning the central nervous system, meldonium effectively eliminates disorders of the functional state of the somatic and autonomic (autonomic) parts of the nervous system, including disorders that accompany withdrawal syndrome in patients suffering from chronic alcoholism.

In addition, the substance has a beneficial effect on the condition of dystrophically altered retinal vessels, which makes it possible to use it for the treatment of vascular and dystrophic pathologies of the fundus.

Pharmacodynamics and pharmacokinetics

The action of the active substance of the drug is aimed at inhibiting the enzymatic activity of γ-butyrobetaine hydroxylase, which is the last enzyme in the chain reaction of L-Carnitine synthesis.

Meldonium helps reduce the concentration of free carnitine, prevents the transport of long-chain fatty acids across cell membranes, and prevents the accumulation in cells of activated forms of unoxidized fatty acids, which are derivatives of acylcarnitine and acyl coenzyme.

In ischemic tissues, it restores the balance between the transport of oxygen and its absorption by cells, prevents disruption of the transport of adenosine triphosphate, while simultaneously activating glycolysis, which occurs without additional oxygen consumption.

The result of a decrease in carnitine concentration is increased synthesis of the vasodilator γ-butyrobetaine.

After taking Mildronate tablets per os, the meldonium it contains is quickly absorbed in the digestive tract. The drug is characterized by a fairly high bioavailability index. The latter is approximately 78%.

The concentration of Meldonium in the blood plasma reaches its maximum values ​​an hour or two after administration. In the body, meldonium is metabolized to non-toxic products - glucose, succinate, 3-hydroxypropionic acid.

Metabolites are excreted by the kidneys. The half-life (T½), depending on the characteristics of the particular organism and the dose taken, can range from three to six hours.

The drug in injection form is characterized by 100% bioavailability. The concentration of Meldonium in the blood plasma reaches its maximum values ​​immediately after administration of the drug. The half-life (T½), depending on the characteristics of the particular organism and the dose taken, can range from three to six hours.

The result of Meldonium metabolization is the formation of non-toxic metabolites (glucose, succinate, 3-hydroxypropionic acid), which are then excreted from the body by the kidneys.

Indications for the use of Mildronate: what Mildronate tablets are for, what the medicine is for in the form of injections

All dosage forms of the drug are intended for the treatment of adult patients.

Indications for use of Mildronate (for all dosage forms of the drug):

• IHD (in combination with other drugs and treatment methods);
• peripheral arterial disease;
• reduced performance;
• encephalopathy;
• physical overload (including in sports);
• postoperative period (to speed up the recovery of the body);
• chronic heart failure;
• cardialgia (pain in the left side of the chest) caused by dishormonal myocardiopathy;
• bronchial asthma;
• COPD;
• alcohol withdrawal (as an addition to specific therapy);
• stroke.

Additional indications for the use of drug injections:

• hemorrhage into the vitreous cavity of the eye (hemophthalmos);
• hemorrhage in the retina of the eye;
• thrombosis and occlusion of the central retinal vein or its branches;
• retinopathy of various origins (for example, hemorrhagic or diabetic).

Use of Mildronate in sports

Mildronate is a drug that is characterized by the ability to expand the range of tolerance to physical (both dynamic and static) stress and intellectual function not only in ischemic injuries, but also in healthy people.

The drug is very useful for athletes due to its properties to improve the nutrition of the heart muscle and other muscles of the body and reduce fatigue, while simultaneously increasing the effectiveness of sports training.

Contrary to popular belief, Mildronate is not used as a means to increase muscle mass. Its task in sports and in bodybuilding in particular is somewhat different: Mildronate for athletes is indicated as a prophylactic agent that prevents fatigue (including the heart muscle) and overtraining.

In addition, by promoting faster removal of breakdown products from cells and accelerating the restoration of cellular energy resources, Mildronate improves metabolism at the cellular level and accelerates muscle recovery in athletes after physical activity. Moreover, the latter applies to both strength loads and physical loads on the speed and/or endurance of the body.

There is an opinion that the use of Mildronate in sports can provoke fatty liver hepatosis. However, it is unfounded.

Mildronate prevents fatty acids from penetrating into the cells and thus prevents the accumulation of fats in the liver. In addition, by burning predominantly sugar, the body spends a larger amount of raw materials, which are fats, for each molecule of adenosine triphosphate produced (that is, for energy production).

Meldonium was not classified as a doping drug until January 1, 2016, which made it possible to use it absolutely legally in all sports.

However, after the introduction of a ban on the use of the drug by the World Anti-Doping Agency (WADA) at the beginning of 2016, a number of athletes, mainly from Russia and the former CIS countries, were caught using this drug. Mildronate also became the subject of a huge scandal when Maria Sharapova admitted using this doping on March 7, 2016.

Mildronate: contraindications for use

Contraindications to the use of Mildronate (for all forms of the drug):

• increased individual sensitivity to Meldonium or any of the auxiliary components of the drug;
• intracranial hypertension, including those caused by intracranial tumors and disorders of venous outflow.

Side effects

Side effects caused by taking Mildronate occur quite often. Typically they are expressed as:

• allergic reactions (redness, skin rashes, itching and swelling);
• dyspeptic symptoms, manifested by belching, attacks of nausea, vomiting, heartburn, a feeling of fullness in the stomach even after a small portion of food;
• tachycardia;
• increased arousal;
• decrease in blood pressure.

Instructions for use of Mildronate

You can often come across the questions “Can Mildronate be administered intramuscularly?” or “Can the drug be injected intramuscularly?”

The instructions for medical use indicate that the drug in injection form is intended for intravenous administration, and capsules and tablets are intended for oral administration (per os).

Dosage forms for oral administration should be taken whole, without chewing, crushing or pouring out the contents of the capsules.

Mildronate for intravenous administration is produced in finished form. Mildronate should be administered intravenously separately from other drugs; dilution with an aqueous solution of sodium chloride is not required (however, in some cases it is allowed).

When injected into a muscle, the injection solution has an irritating effect and can provoke local pain and local allergic reactions. For this reason, the drug Mildronate is usually injected into a vein.

Mildronate injections: instructions for use, why they are prescribed and how to dose the injection solution

Indications for the use of Mildronate injections: unstable (progressive) angina pectoris, myocardial infarction, vascular pathologies of the fundus and cerebral circulatory disorders.

For patients with coronary syndrome, the drug is injected into a vein in a dose equal to mg, once a day. After this, therapy is continued by taking tablets or capsules.

For patients with vascular pathologies of the fundus of the eye, the medicine is administered retrobulbarly (behind the eyeball) or subconjunctivally (under the outer shell of the eyeball) 0.5 ml for 10 days.

For patients with cerebral circulatory disorders in the acute stage, the solution is administered into a vein once a day at a dose of 500 mg. The duration of the therapeutic course is 10 days. Further treatment is carried out using oral dosage forms.

Patients with chronic cerebral circulatory disorders are advised to administer Mildronate intramuscularly one to three times a day at a dose of 500 mg (optimally before lunch). The duration of the therapeutic course is from 2 to 3 weeks.

Mildronate tablets: instructions for use

For patients with diseases of the cardiovascular system, Mildronate tablets and capsules are indicated in combination with specific therapy. The drug is taken 1 mg per day. The entire dose can be taken either at once or divided into two doses.

As a rule, the course of treatment lasts from 4 to 6 weeks.

For cardialgia caused by dyshormonal myocardiopathy, Mildronate is taken once a day, one 500 mg tablet or 2 250 mg tablets.

For patients with cerebral circulatory disorders, after eliminating acute disorders, the drug is recommended to be used at a dose equal to mg per day. Take it in one dose or divided into two doses.

Patients with chronic cerebral circulatory disorders are recommended to take 500 mg of Mildronate per day.

The duration of treatment varies from 4 to 6 weeks. At the discretion of the attending physician, the patient may be prescribed repeated courses of treatment (usually two or three times a year).

Patients with pathologies of peripheral arteries are prescribed to take the drug twice a day, 500 mg. The recommended dose for increased intellectual and physical stress on the body (including athletes) is mg, which should be divided into two doses.

The duration of treatment is from 10 to 14 days. If necessary, the course is repeated after a two- or three-week interval.

In the period before training, athletes are recommended to take Mildronate twice a day at a dose equal to mg. The duration of treatment in the preparatory period is usually from two to three weeks, during the competition period its duration varies from 10 to 14 days.

For alcohol withdrawal, patients suffering from chronic alcoholism should take Mildronate 500 mg four times a day. The duration of the course is from 7 to 10 days.

The maximum permissible daily dose is considered to be 2000 mg.

Overdose

No cases of overdose have been recorded. The drug Mildronate is characterized as low-toxic and does not provoke side effects that could threaten the patient's health.

Interaction

Combination of Mildronate with antianginal, antiarrhythmic, anticoagulant, antiplatelet and diuretic drugs, cardiac glycosides, bronchodilators and other drugs is allowed.

Mildronate has the ability to potentiate the effect of Nitroglycerin, β-adrenergic blockers; nifedepine and other drugs that have a coronary effect; antihypertensive drugs, as well as drugs whose action is aimed at dilating peripheral blood vessels.

Due to the possible development of moderate tachycardia and a decrease in blood pressure, the above drugs should be used in combination with Mildronate with caution.

Terms of sale

Mildronate belongs to the category of prescription drugs.

Storage conditions

Mildronate should be stored in a dry place. Keep away from children. The optimal temperature is not higher than 25°C.

Best before date

special instructions

Due to the fact that the drug can provoke a stimulating effect, it is recommended to use it in the first half of the day.

There are no data regarding the ability of Mildronate to change the reaction rate and influence transport control.

The drug is prescribed with caution to people with liver and/or kidney pathologies.

Experience in treating patients with myocardial infarction and unstable angina shows that the active substance Mildronate is not a first-line drug for ACS.

Analogues of Mildronate

The price of drug analogues starts from 170 Russian rubles.

Riboxin or Mildronate - which is better?

Riboxin is a natural compound found also in the human body.

Being a precursor of adenosine triphosphate, it helps to increase the energy balance of the heart muscle, improve coronary circulation, reduce the severity of the consequences of intraoperative ischemic kidney damage, stimulate the production of nucleotides and the activity of individual enzymes of the citrate cycle.

The drug has a positive effect on metabolic processes in the heart muscle, increases the force of its contractions and stimulates its more complete relaxation in diastole, which in turn leads to an increase in stroke volume (stroke volume of blood).

Mildronate has a similar effect, but is not itself involved in the synthesis of other substances. At the same time, the drug regulates the activity and biosynthesis of enzymes involved in energy production, and thus normalizes metabolism.

The conclusion is this: Mildronate is a drug whose action is aimed at correcting metabolic processes, while Riboxin takes part in biochemical reactions and is a means of metabolic action.

To obtain the expected effect from the use of Riboxin, it should be administered in quantities that are comparable to its consumption in the body. And since Riboxin is used by the body in various reactions, it is required in very large quantities.

Mildronate, on the contrary, is not consumed in metabolic reactions, its effect lasts for a longer period of time, and its body requires much less than Riboxin.

Therefore, the use of Mildronate also improves the body’s use of Riboxin. Thus, the combined use of these drugs will potentiate each other's effects.

Cardionate or Mildronate - which is better?

Cardionate and Mildronate are synonymous drugs. They are based on the same active ingredient, so both products have a similar mechanism of action.

The only difference is that, unlike Mildronate, Cardionate is available only in the form of 250 mg capsules and 500 mg/5 ml injection solution.

Prescription of Mildronate for children

Since today there is insufficient data on the safety of Mildronate in pediatric practice, the drug should not be used to treat children.

Alcohol compatibility

The active substance of Mildronate is excreted from the body within 12 hours, therefore, after this time, the risk of interaction of the drug with another active substance is extremely low or completely absent.

In general, drinking alcohol during treatment with Mildronate is not prohibited; however, if this drug is used to treat a cardiovascular disease or a cerebral circulatory disorder, the patient is still advised to stop drinking alcohol.

This is due to the fact that taking the drug in combination with alcohol can negate all the positive results that have been achieved in treating the disease.

Taking Mildronate with alcohol can provoke:

The poor compatibility of Mildronate with alcohol is due to an increased risk of various types of complications and the likelihood of a relapse of the disease. For this reason, alcohol should be excluded for the entire period of treatment with the drug.

Use of Mildronate during pregnancy and lactation

The safety of Mildronate for the treatment of pregnant women has not been proven. To exclude the possibility of its adverse effects on fetal development, the drug is not prescribed during pregnancy.

It has not been established whether meldonium can be excreted in the milk of a nursing woman. Therefore, if treatment with Mildronate is indicated for the mother, she must stop breastfeeding for the entire period of therapy.

Until recently, the drug Mildronate, familiar to many, was considered a simple medicine, widely used in our country for the treatment of diseases such as ischemia (IHD), angina pectoris, myocardial infarction and strokes. However, for a number of reasons, in sports circles it was included in the anti-doping list, which is why ordinary people began to wonder whether this drug was harmful and whether it was worth taking it?

Pharmacology of the drug

The instructions for use of Mildronate say that its active substance is meldonium, which was synthesized in the seventies by Latvian scientists. Initially, the drug was developed for the military, but due to some reasons it became available to a wider audience for the treatment of cardiovascular diseases. Meldonium is a substance that is an analogue of gamma-butyrobetaine contained in the cells of our body, which protects them from damage due to coronary artery disease, heart failure, and cerebral circulatory disorders.

In addition to protection, Mildronate nourishes the body's cells with the necessary amount of oxygen and cleanses them of toxins that are the result of metabolic processes. It also strengthens the walls of blood vessels, ensuring their integrity. The drug is an excellent prophylactic for varicose veins.

With long-term use of Mildronate, our body is able to withstand enormous physical stress and restore energy balance in a short time, which allows it to be used as a medicinal and prophylactic agent for disorders of the blood supply to the brain and diseases of the heart and blood vessels.

Often, it is prescribed to patients with decreased performance and to increase mental activity. In case of ischemic heart disease, meldonium slows down necrotic processes and accelerates the recovery period.

Indications

The drug is a panacea for many diseases. Its scope is quite wide. Indications for the use of Mildronate:

• Coronary heart disease in complex therapy;
• Various cardiovascular pathologies - angina pectoris, myocardial infarction, myocardial dystrophy, heart failure;
• Acute cerebrovascular accidents (stroke), and chronic form;
• Disorders of the heart muscle in adolescence;
• Bronchial asthma and chronic bronchitis;
• Poor blood circulation in the retina of the eyes due to hypertension and diabetes mellitus;
• Chronic fatigue, physical overstrain and decreased performance;
• Postoperative period for a speedy recovery of the body.

Treatment with the drug is carried out strictly under the supervision of a doctor.

Forms of release of the drug, composition

Mildronate is produced in several forms, these are:

• Capsules for oral use in a gelatin shell containing white powder 250 and 500 mg (40 and 60 pieces per package);
• Syrup for oral administration;
• Ampoules 5 ml, 10 pieces per package.

Mildronate tablets

One of the forms of release of the product is capsules, often called tablets. In accordance with the instruction on the use of tablets, they include:

• Active component meldonium - 250 or 500 mg;
• Potato starch - 13.6 or 27.2 mg;
• Colloidal silicon dioxide - 5.4 or 10.8 mg;
• Calcium stearate - 2.7 or 5.4 mg;
• Shell - gelatin (98%) and titanium dioxide (2%).

Sold in a cardboard box of 40 or 60 pieces.

Ampoules for intravenous and intramuscular injections, according to the instructions for use, 5 ml contain:

• Meldonium - 500 mg;
• Water for injections.

Ampoules are produced in a cardboard box of 10 pieces with a dosage of 5 ml.

The substance in the ampoules must be absolutely transparent. If there is any sediment in it, then this medicine cannot be used.

Syrup

Mildronate is also produced in the form of a dark syrup of 100 and 250 ml, which contains 250 mg of meldonium per 5 ml of medication. In addition to the active component, the syrup contains auxiliary substances - cherry essence, purified water, glycerin, dyes, propylene glycol.

The syrup is sold in cardboard boxes; the kit includes a 5 ml measuring spoon.

How to take Mildronate

Typically, capsules are taken 30 minutes before meals. Due to the fact that the drug can increase performance, it is recommended to use it before 17.00 to avoid problems with sleep. Capsule dosage: 500 - 750 mg per day. The syrup is taken in a measuring spoon 2-4 times a day before meals or no earlier than 30 minutes after meals.

The standard dosage of injections is 500 mg or 1 g per day once or by dividing the dose into 2 parts. The drug is used in the first half of the day. In acute cases of the disease, Mildronate is recommended to be administered intravenously.

The dosage may vary depending on the type of disease and its severity.

The dose of the medicine is prescribed by the attending physician individually for each patient.

Contraindications

Every medication has some contraindications. Mildronate is no exception. It is not recommended for use in the following cases:

• With high levels of intracranial pressure;
• For brain tumors;
• Children under 12 years of age;
• The presence of individual intolerance;
• During pregnancy and breastfeeding.

Side effects and overdose

Mildronate is generally well tolerated by patients. Rarely, when using the medicine, various allergic manifestations (rashes, urticaria, swelling), dyspepsia, rapid heartbeat (tachycardia), sudden changes in blood pressure, excited states or general weakness may occur.

If such symptoms occur, you should stop using the medicine.

An overdose of the drug can cause a sharp decrease in blood pressure, headache, dizziness with loss of consciousness, weakness, and tachycardia.

Alcohol compatibility

The instructions for using Mildronate do not contain information about how it behaves when used with alcoholic beverages, but like many medications, it should not be used together with alcohol due to the fact that meldonium itself has a very active effect on blood circulation, and together with When taken with alcohol, it can cause sudden changes in blood pressure due to the dilation and constriction of blood vessels. This condition is extremely undesirable for patients.

Mildronate and sport

Despite the fact that meldonium increases the endurance of athletes and helps quickly recover after enormous physical exertion, it was banned from use in sports, being included in the list of doping substances.

The influence of Mildronate on those who play sports is simply irreplaceable

It is recommended for all sports without exception due to the fact that it helps to avoid overwork during long training sessions. It is most suitable for athletes and bodybuilders because it improves the nutrition of muscle tissue, protects the heart muscle from overload and enriches cells with oxygen, and also reduces fatigue, increasing the effectiveness of each workout.

How to lose weight with Mildronate

Meldonium is an active component of the drug L-carnitine (an analogue of Mildronate), which is successfully used by athletes for rapid weight loss. It lowers blood cholesterol and improves metabolic and fat processes. But the process of losing weight with the help of this product is possible only with intense physical activity and proper nutrition.

Analogues of Mildronate

In Russia, analogues of the Latvian drug Mildronate containing meldonium are produced, these are:

• Methadern;
• Idrinol;

The most popular product is Cardionat, produced in Moscow and Nizhny Novgorod.

Which is better, Mildronate or Cardionate? There is no clear answer to this question. Despite the fact that both drugs have the same active ingredient - meldonium, and the compositions are almost similar, and the only difference is in price, judging by the reviews of patients, the effect of Mildronate is more pronounced than the effect of Cardionate. The effect after using the Latvian remedy appears more clearly, and its manifestation occurs much faster.

The benefits and harms of the drug

Ordinary people, having heard about the scandalous story involving Mildronate in sports, began to increasingly wonder whether this drug was harmful to them? Cardiologists are in a hurry to reassure: those to whom the drug was prescribed by doctors for one reason or another can safely continue to take it, however, it is still not worth using it constantly, it is addictive, so it is recommended to use the drug for no more than two weeks, after which it is worth taking two week break.

Despite all the above advantages of the drug, it is also not recommended for ordinary people to use it for prophylaxis during sports; it should not interfere with the normal functioning of the heart. Absolutely healthy individuals do not need to use it.

Prices

The cost of capsules with a dosage of 250 mg in an amount of 40 pieces fluctuates around 300 rubles, and 60 pieces of 500 mg capsules cost a little more than 600 rubles.

The medicine in ampoules can be purchased in pharmacies for 400-450 rubles, and the syrup costs from 250 rubles per 250 ml bottle.

During heavy fighting in Afghanistan, Soviet scientists began to think about increasing the performance and endurance of soldiers, as well as reducing their mortality. Severe stress, hypoxia, and excessive physical activity undermined the health of employees.

Then scientists thought about a substance that could support the body under such conditions. They analyzed the work of German scientists in the 20s and discovered a chemical compound released by the body under stress.

In the early 80s, Latvian pharmacists invented a drug based on meldonium, a substance that normalizes metabolic processes in body cells exposed to hypoxia or ischemia. Then Mildronate, a medicine that mobilizes vital energy in the body, was released into mass production. This drug began to be widely used by athletes and the military because of its wonderful properties. Next, the fact was discovered that Mildronate is able to help people with heart disease.

Today this drug is the best-selling drug in Russia and the CIS countries; people like to use it in treatment and as an assistant in restoring strength.

The drug is available in the form of tablets, capsules or ampoules with liquid for injection:

1. Injections in ampoules contain a clear, colorless liquid with a volume of 5 ml (500 mg/5 ml). They are packaged in packs of 10 ampoules, each pack contains attached instructions for use. Mildronate ampoules consist of 100 mg of Meldonium and water for injection.
2. Capsules made from gelatin contain 250 or 500 mg of Meldonium and excipients. The capsule powder has a characteristic mild aftertaste. The capsules are packaged in blisters, each pack contains 4 blisters of 10 capsules each, and instructions for use of the medicine.
3. Mildronate tablets have a slightly sour taste. Each tablet contains 500 mg of Meldonium and excipients. The box contains 40 tablets and instructions for use.

How does Mildronate affect the body?

The active component of the drug, Meldonium is a synthetic substance similar to human γ-butyrobetaine (a substance similar to B vitamins). This substance can improve metabolism and enhance the process of energy exchange in the cells of the body, which characterizes the healing properties of the medicine.

Meldonium is able to activate tissue and anti-infective immunity. From the cardiovascular system, Mildronate helps cardiac activity, giving strength to contractions, as well as to endure heavy physical activity.

The medicine can help with coronary heart disease by helping to redistribute blood in damaged areas. Injections successfully help with chronic heart failure. Mildronate increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks.

Mildronate allows you to quickly deliver oxygen to cells during physical stress, then removes the products of cellular metabolism with toxins from the body. At the same time, Mildronate is able to protect cells from damage, replenish energy reserves and maintain a high metabolic rate in the body.

The drug can help with chronic alcoholism by stimulating the nervous system. Meldonium may also be useful in treating seizures and alcohol intoxication.

In tandem with other drugs such as metformin, the drug has been shown to have beneficial effects on neurological disorders and diabetes.

Meldonium also has indications for mental stress; it can improve learning and memory.

Some studies have shown the drug's ability to affect sperm motility and increase the concentration of testosterone in the blood of men, which has a beneficial effect on sexual performance and the conception of a healthy child.

Under conditions of high load, Mildronate restores the balance between the supply and demand for oxygen in cells, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage, and also has a tonic effect. As a result of its use, the body acquires the ability to resist stress and quickly restore energy reserves.

Treats acute and chronic ischemic disorders of cerebral circulation, improves blood circulation in the ischemic area, promotes blood redistribution in favor of the ischemic area.

The indication for use of the drug is vascular pathology and retinal dystrophy.

How is the drug processed by the body?

When consuming Mildronate tablets or capsules, the active substances are quickly absorbed into the digestive tract. The medicine is processed by the body by 78%, the rest is excreted from the body through the kidneys.

1-2 hours after taking the tablet, the concentration of the drug in the blood reaches its maximum. After this, Mildronate decomposes into non-toxic products: glucose, succinate and hydroxypropionic acid. The kidneys remove these substances from the body within three to six hours.

In the form of an injection, the drug is processed by the body 100%. Immediately upon administration of the drug, its concentration increases as much as possible in the blood. Therefore, intravenous injections are used for the fastest possible effect on the affected areas.

In what form is it better to take the drug?

There are indications for the use of the drug both in tablets (or capsules) and in injections intravenously and intramuscularly for the following diseases:

1. Cardiac ischemia.
2. Peripheral arterial diseases.
3. Chronic form of heart failure.
4. Encephalopathy.
5. Cardialgia with dyshormonal myocardiopathy.
6. Bronchial asthma.
7. Alcohol withdrawal.
8. Brain stroke.
9. Physical and mental overload.
10. Decreased performance and
11. The period of recovery of the body after surgery.

Mildronate injections have additional indications:

1. Damage to the vitreous body or retina of the eye, and as a result - hemorrhage.
2. Thrombosis of the central vein of the eye or its branches.
3. Retinopathy (damage to the blood vessels of the eye, for example, as a complication of diabetes).

Capsules or tablets of the drug should be taken without chewing, crushing or breaking the membranes, orally.

Injections are administered intravenously, since an intramuscular injection provokes severe pain and can provoke local allergies. But some indications take into account that intramuscular injection of the drug is necessary. For example, with chronic cerebral circulatory disorders.

For diseases of the blood vessels of the eye, the drug is administered by injection behind the eyeball or under the outer shell of the eye.

Use of the drug during sports

Mildronate is widely known among professional athletes for its properties in helping the body recover after intense training.

It is immediately necessary to understand that the drug is not a dope. It is allowed when exercising both power and dynamic loads.

Meldonium helps oxygenate cells in need and removes breakdown products. In addition, it energetically nourishes cells. These actions contribute to faster recovery after heavy physical exercise, which means better training results. When an athlete recovers faster, he starts the next workout earlier, and then his productivity increases.

Indications for the use of the drug for athletes exist when he has a period of intense and frequent training, and he does not have time to recover between them. The instructions for use are as follows: capsules or tablets should contain up to 1 gram of the substance per day in a total dosage; take them 30 minutes before training.

Intravenous injections are more effective; the daily dose for an athlete is 5-10 ml. The course of treatment should last no longer than six weeks. The drug is not addictive.

It should be remembered that taking an injection of medication or orally capsules or tablets will not replace the athlete with a nutritious diet rich in carbohydrates and proteins. If you are on a very limited diet, there is no point in taking Mildronate, since it will not affect the exhausted body.

The ability of the drug to prevent fatty acids from entering the body's cells helps to achieve a weight loss effect during intense exercise.

When is Mildronate contraindicated?

1. The instructions for use of the medicine clearly indicate a warning about allergic reactions to the components of the drug. Its use should be interrupted if you notice itching or redness on your skin, shortness of breath or swelling.
2. For symptoms of indigestion or poor stomach function - heartburn, bloating, vomiting, belching, and the like.
3. Increased excitability.
4. Tachycardia.
5. Low blood pressure.
6. Pregnancy and breastfeeding period.
7. For pathologies of the kidneys and liver, this substance is prescribed in extreme cases.
8. There is insufficient data on the use of Mildronate in children.

Due to the fact that the drug is considered non-toxic, in case of an overdose it will not cause excessively dangerous side effects.

The instructions remind you that you cannot combine the use of medication and alcohol, especially if it is used to treat cardiovascular diseases.

The drug is sold in pharmacies only with a prescription from the attending physician.

It is better to take it only in the first half of the day, as it can cause a stimulating effect on the nervous system. There is no information on the effect on driving.

Normalization of metabolic processes in the body at the level of tissues and cells is necessary for patients of different age categories not only for the treatment of various pathologies, but also for the prevention of complex failures and disorders. Mildronate is considered a modern drug with such a targeted action, the instructions for use of which recommend using the drug to treat almost all systems and organs. Let's look in more detail at what the drug is prescribed for, how much it needs to be taken, whether to dilute it or not when injected.

The drug is produced by pharmaceutical companies in different forms, which makes the use of Mildronate almost universal. The medication itself has a complex therapeutic effect, but the main direction is to ensure and normalize metabolic processes in tissues and cells.

Directed Action	Therapeutic effect
Protective and preservative	Protection of the heart organ and its tissues at the cellular level from harmful effects
Regulatory	Regulation and reduction of the expressed need of cells for oxygen nutrition
Stimulating	Minimizes the degree of negative impact from oxygen deficiency by stimulating oxygen metabolism
Preserving	Protecting and preserving the walls of blood vessels intact and unharmed
Invigorating	Restoring energy balance

The drug is indicated

What is the remedy prescribed for? Mildronate should be taken according to the recommendation and prescription of doctors, despite the fact that the drug itself has a wide range of therapeutic effects.

The main indications for treatment with Mildronate are:

• recurrent and chronic pathological conditions of the cardiac and vascular system;
• severe circulatory disorders, including peripheral and cerebral;
• symptoms of chronic fatigue.

At the same time, experts classify the form of administration and quantitative characteristics of the drug depending on the nature and location of the pathology and the age category of the patient.

Indications for cardiac pathologies

• ischemic damage to the heart organ;
• attacks of “angina pectoris”, or angina pectoris;
• infarction and post-infarction conditions;
• states of chronic cardiac failure;
• cardiomyopathy due to hormonal disorders;
• painful spasms during failures and disorders of the myocardium.

As part of a combination treatment, Mildronate is prescribed intravenously or Mildronate tablets. The dosage is adjusted by the treating doctor.

Indications for circulatory pathologies

For diseases and problems with the circulatory system, you can take the drug in ampoules and tablets. The following hematopoietic diseases are considered indications for taking Mildronate:

• stroke conditions and cerebrovascular insufficiency;
• circulatory disorders in the retina.

How to take Mildronate? Is it better to inject Mildronate or swallow tablets? For some pathological circulatory conditions associated with the organs of vision, patients are prescribed Mildronate in ampoules as an injection. Indications for such treatment are the following pathologies:

• stroke lesions of the retina in the form of hemorrhages;
• hemophthalmos;
• complex pathologies of the retinal vein.

This drug is also used for the treatment of many complex pathologies affecting the organs of the respiratory system, as well as for the treatment of mental forms of addiction.

Treatment of other complex pathologies

The regimen, dosage form and dosage of taking the drug for the complex treatment of complex pathological conditions is also adjusted by the doctor. Mildronate can be taken together with other medications for the following chronic and complex pathologies:

• retinopathy of diabetic and hypertensive origin;
• bronchial and asthmatic spasms;
• alcohol intoxication and dependence;
• asthenic syndrome;
• postoperative period after surgery.

Mildronate is also prescribed to people engaged in heavy physical and mental labor, and to athletes against the backdrop of increased stress during training. For example, in powerlifting, the drug is used to prevent muscle fatigue and improve the health of the body as a whole. It is mistakenly believed that the drug helps build muscle mass. Athletes are recommended to take Mildronate together with other vitamin supplements. Is it possible to take the drug uncontrolled? Of course not! Even for preventive purposes, taking the medication must be strictly dosed.

Admission rules

Specialists prescribe Mildronate to their patients in capsules or by injection, stipulating the rules for taking the medicine. The main condition for effective treatment is the correct and timely administration of this medication at least five hours before bedtime.

The optimal dosage is determined depending on the age category of the patient and the direction of the therapeutic effect. The tablet should be taken half an hour before or after meals. You should not combine taking pills with food.

Treatment of cardiac pathologies

To treat heart problems of complex origin, doctors successfully use Mildronate injections, subsequently transferring the patient to capsule forms of the drug.

Pathology	Dose	Form of the drug	Scheme	Duration of admission
Stable Angina	250	Capsules	3 times a day	3 days
	250		1 time per day	6 weeks
Unstable angina	1000	Ampoules	1 time per day	1 day
	250	Capsules	2 times a day	4 days
	250		1 time per day	5 days
Dishormonal myocardial dystrophy	250	Capsules	2 times a day	2 weeks
Post-infarction conditions	250	Capsules	2 times a day	6 weeks

As a rule, when treating heart pathologies, doctors must take into account and tell their patients the fact that the last time Mildronate intramuscularly, like Mildronate capsules, should be taken no later than five to six hours before bedtime.

Therapy of circulatory pathologies

In case of cerebrovascular disorders and acute disorders of general blood flow, drug therapy is carried out strictly according to the indications of the treating doctor, who also adjusts the dosage taking into account the severity and direction of the pathological condition.

The doctor calculates how much medication is needed for pediatric and adolescent patients, based on the patient’s age and weight. A certain volume is distributed over a couple of doses during the day; the duration of the course in such patients varies from 3 to 5 weeks.

Drug for other pathologies

Considering that in the complex treatment of complex and chronic pathologies, the patient is prescribed a number of potent targeted medications, Mildronate tablets and injections are used to reduce the manifestations of intoxication and remove toxins and breakdown products from the body.

1. For chronic bronchial pathologies, the patient is prescribed Mildronate 250 times a day. The duration of treatment for this pathology varies from two to three weeks and depends on the severity of the relapse of the disease.
2. For the treatment of chronic forms of alcohol dependence, Mildronate 500 mg is used 4 times a day (you can drink it twice a day, dividing the dose into two doses). The duration of therapy for this form of pathology is from a week to ten days.
3. For comprehensive recovery of the patient in the postoperative period or against the background of heavy physical activity, it is recommended to take Mildronate 250 mg 4 times a day.

This drug is also taken in the same way in the treatment of chronic fatigue syndrome, with prolonged mental strain and overload. Taking Mildronate in capsules of 500 mg twice a day is also considered effective. It is important to adhere to the recommendations regarding the treatment time interval.

Rules for injection treatment

The injection solution is used for injection into the patient’s muscle tissue directly into a vein, or parabulbarly.

When using Mildronate in injections, the instructions stipulate a number of specific rules that must be taken into account in order not to harm the patient.

1. The ampoule with the drug should be opened immediately before injection. Experts note that the unopened Mildronate solution can be kept for no longer than the specified time interval, after which it becomes unsuitable for injection.
2. The injected solution should not have a coloration; no sediment, flakes, or cloudy additions should be visible in it. If flakes, sediment, or cloudiness of the solution are already observed in the sealed ampoule, then administering it is strictly prohibited. Such a medicine not only will not help the patient, but can provoke a purulent infiltrate at the injection site.
3. It is recommended to administer Mildronate in the evening no later than 18 hours, as it is able to actively stimulate metabolism, stimulating certain centers of the brain. Otherwise, a person may suffer from severe night sleep disturbance.

The recommended quantitative measure when using the drug for injection is calculated by the attending physician and, as a rule, is Mildronate 500 ml per day for injection into the patient’s muscle tissue or vein.

Injection dosages

The accepted and approved dose of the drug for any injection is 0.25 - 0.5 g of Mildronate per day, but for parabulbar infusions - 50 mg per day. However, often these indicators can increase or decrease according to the indications of the treating doctor, depending on the severity of the person’s condition and the type of disease.

1. In case of false pathological conditions of the functioning of the cardiac system, the accepted dosage of the drug should be administered intravenously or it may be increased no more than twice. The drug is administered at a time or, if possible, divided into a pair of injections. Injections are given to the patient for one day, after which oral administration is allowed. However, if there are contraindications to oral treatment, it is worth continuing the intravenous course.
2. For cardiac pathological instability, the drug is administered intravenously in a standard dose once a day or into the patient’s muscle tissue twice a day for a couple of weeks. After completion of injection therapy, the patient is transferred to oral administration in the form of capsule forms for one month.
3. In the severe phase of the pathology, when there is a disruption in the blood supply to the brain cells, the drug is administered directly into a vein once a day for 10 days. After which it is considered advisable to transfer the patient to take the drug in tablet form or in the form of syrup. Intramuscular administration is also possible.
4. For painful heart spasms against the background of myocardial dystrophy caused by hormonal disorders, the medicine is administered intravenously once a day. It is also possible to administer intramuscularly twice a day for two weeks.
5. For mental and physical overload, as well as to speed up rehabilitation after surgery, this medication can be administered intravenously, intramuscularly once or twice a day for a couple of weeks.
6. Chronic alcohol dependence is treated with intravenous injections if the patient is diagnosed with severe damage to the nervous system. In this case, it is advisable to administer twice a day for a week.
7. In case of pathological disorders of the fundus vessels or retinal dystrophy, Mildronate is administered by the parabulbar method once a day for 10 days.

Side effects

Among the broad-spectrum medications, there are few that are almost always well tolerated by patients. But Mildronate is one of these drugs, characterized by a minimal set of possible side effects during treatment. Experts draw attention to the fact that extremely rare undesirable manifestations occur against the background of individual failure to take the active components of the drug.

Possible undesirable manifestations from taking Mildronate include:

• allergic manifestations in the form of redness of local areas of the skin, accompanied by swelling and itching;
• manifestations of dyspepsia: nausea, feeling of a full stomach, bouts of vomiting;
• increased heart rate;
• nervous and psychomotor overexcitation;
• disturbances in night sleep due to non-compliance with the time intervals of the treatment regimen;
• hypotonic blood pressure indicators.

If an undesirable reaction of the body to the drug occurs, experts recommend making a change within the dosage form: switching from capsules to solution or vice versa. If this action does not eliminate the symptoms, then the drug is discontinued or replaced with a similar one, but with a different active substance.

Medicine for menopause

Mildronate's ability to regulate metabolic processes is also used by specialists for metabolic disorders caused by menopause.

1. During the climatic period, a woman’s hormonal metabolism and general metabolism are disrupted, which contributes to the deposition of fat accumulation in the body and an increase in body weight. Mildronate during menopause will help normalize metabolism and block the production of fat deposits.
2. By participating in metabolic processes at the cellular level, Mildronate helps reduce the manifestations of intoxication, thereby significantly reducing the discomfort of the onset of menopause and its main symptoms.

Experts often prescribe Adaptol to their patients along with this drug for comprehensive relief from menopausal symptoms and irritability. This combined use helps not only to correct and eliminate unwanted manifestations of age in the form of weight gain, but also relieves irritability and hyperexcitability.

Contraindications for use

Like any drug, Mildronate has a number of contraindications for use, which should be taken into account when deciding to be treated with it. Experts include such contraindications:

• increased intracranial pressure in the patient’s history, progressing against the background of impaired venous blood flow;
• the presence of intracranial neoplasms of various etiologies;
• pregnancy at any stage and breastfeeding, since the drug has high penetrating ability and can concentrate in liquids;

This drug is also not prescribed to children under 12 years of age. When treating with Mildronate, doctors also take into account possible allergic reactions to the components of the medication, so they prescribe it to allergy sufferers with special caution.

Symptoms and treatment of overdose

Considering that the drug itself belongs to the group of low-toxic drugs, manifestations of overdose during administration are practically not recorded. There are only rare observations of changes in the general condition of the patient, which can manifest themselves in the form of the following symptoms:

• headache and cramps accompanied by dizziness and nausea;
• attacks of tachycardia and chest tightness against their background;
• jumps in arterial systolic and diastolic parameters;
• weakness and asthenic syndrome;
• local allergic manifestations on the skin.

To eliminate such manifestations, the patient needs symptomatic therapy, which consists of:

• taking antihistamines;
• use of analgesics and painkillers;
• treatment with drugs that stabilize blood pressure and heart rate, including sedatives.

If the body is intolerant to this drug, specialists can replace it with analogues. Analogues of Mildronate on the pharmaceutical market are drugs with a similar action. Specialists select a medicinal analogue depending on the severity of the pathology and the individual characteristics of the patient’s body.

Doctors point out that self-medication with any drug (Mildronat and its analogues is no exception) can lead to disastrous consequences. Before making a decision on therapy, it is worth consulting with a doctor who will select the optimal drug, dosage form and, if necessary, determine a similar drug substitute.