What are these tablets for? Remantadine. Remantadine: what does the medicine help with, how to take it? Treatment of influenza and viral diseases in adults

Active substance: rimantadine (rimantadine hydrochloride) - 50 mg.

Excipients: lactose (milk sugar), potato starch, talc, calcium stearate.

Pharmacotherapeutic group

Antiviral agent for systemic use. Cyclic amines. Rimantadine.

Indications for use

Prevention and early treatment of influenza in adults and children over 7 years of age, prevention of influenza during an epidemic in adults.

Contraindications

hypersensitivity to rimantadine or other adamantane derivatives, as well as to any of the excipients included in the drug; galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption; acute liver diseases, severe liver dysfunction; acute kidney disease, severe renal dysfunction; thyrotoxicosis; pregnancy and breastfeeding; children's age up to 7 years.

Interaction with other drugs

Pharmacodynamic: rimantadine reduces the effectiveness of antiepileptic drugs.

Pharmacokinetic: adsorbents, astringents and coating agents reduce the absorption of rimantadine.

Urine acidifying agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.

Paracetamol and ascorbic acid reduce the maximum plasma concentration of rimantadine by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

Live attenuated influenza vaccine (LAIV): Concomitant use of rimantadine and live attenuated intranasal influenza vaccine has not been evaluated. However, because of the potential for interactions between these products, live attenuated intranasal influenza vaccine should not be administered until 48 hours after stopping rimantadine, and rimantadine is not recommended for use within two weeks of administration of live attenuated intranasal influenza vaccine unless required for medical reasons. Concerns about possible interactions primarily arise from inhibition of live vaccine virus replication caused by antiviral agents.

You should refrain from drinking alcohol, because... Unexpected reactions from the central nervous system may occur.

Precautionary measures

It should be used with caution in patients with gastrointestinal pathology, mild or moderate hepatic and/or renal failure, severe heart disease (including heart rhythm disorders), and in elderly patients. In these cases, it is recommended to reduce the dose. The medicine contains lactose, rimantadine should not be taken by patients with rare congenital galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.

There is limited data on the use of rimantadine in patients with acute or chronic liver failure, acute or chronic renal impairment. In such patients, rimantadine is recommended to be taken as prescribed by a doctor, after assessing the ratio of expected benefits and potential risks, as well as deciding on the need for dose adjustment.

Taking Rimantadine is not a substitute for early influenza vaccination as recommended by national health authorities.

When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke. If there is a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg per day simultaneously with anticonvulsant therapy. If a seizure develops, rimantadine should be discontinued.

Prophylactic administration is effective during contacts with sick people, during the spread of infection in closed groups and at a high risk of developing the disease during an influenza epidemic.

Drug-resistant viruses may emerge.

To reduce the likelihood of developing resistance to rimantadine, it is recommended to discontinue use as quickly as clinically possible, usually approximately 5 days after the start of treatment or 24-48 hours after symptoms resolve.

Use in children

This medicine can be used in children over 7 years of age. It is recommended to consult a doctor before use.

Use during pregnancy and lactationyu

Use is contraindicated. There are no adequate and well-controlled clinical studies on the use of rimantadine during pregnancy and lactation. In animal experiments, it was established that rimantadine penetrates the placental barrier and is excreted in breast milk.

The concentration of rimantadine in milk 2-3 hours after taking a single dose exceeds the concentration in blood plasma.

Impact on the ability to drive or operate moving machinery

Directions for use and dosage

Take orally after meals with water. Treatment for influenza should begin within 24-48 hours of the onset of symptoms.

For the treatment of influenza

For adults Rimantadine is prescribed according to one of the following regimens:

Scheme 1: V first day: 100 mg 3 times a day, on days 2 and 3 - 100 mg 2 times a day, on days 4 and 5 - 100 mg 1 time a day. On the first day of the disease, it is possible to use 150 mg 2 times a day or 300 mg in 1 dose.

Scheme 2 : 100 mg 2 times a day for 5 days.

Aged people over 65 years old: 100 mg 1 time per day.

For children from 7 to 10 years are prescribed 50 mg 2 times a day, 11-14 years - 50 mg 3 times a day. Children over 14 years of age are prescribed doses similar to those in adults.

Use in patients with mild to moderate liver dysfunction:

Rimantadine is contraindicated in severe liver dysfunction.

Use in patients with mild renal impairment (creatinine clearance 50-80 ml/min) and moderate severity (creatinine clearance 30-49 ml/min):

Rimantadine is contraindicated in severe renal failure.

For flu prevention

Rimantadine is prescribed 50 mg once a day for 10-15 days.

If you miss a dose, take it as soon as possible, but skip it if it is near the time of your next dose. Do not take a double dose to make up for a missed dose.

Overdose

There is no information about an overdose of rimantadine. In case of poisoning, it is necessary to ensure the maintenance of vital functions. Cases of poisoning with a chemical analogue of rimantadine, amantadine, have been described.

Symptoms: agitation, hallucinations, arrhythmias, death.

Treatment is symptomatic, aimed at maintaining vital functions. Intravenous administration of physostigmine is recommended: 1-2 mg for adults and 0.5 mg for children, but not more than 2 mg per hour. Rimantadine is not removed by hemodialysis.

Side effect

Like all medicines, rimantadine may cause side effects. Frequency of side effects according to the MedDRA (Medical Dictionary of Regulatory Activities) classification system:

Very common (≥ 1/10)

Frequent (≥ 1/100 to

Uncommon (≥ 1/1000 to

Rare (≥ 1/10,000 to

Very rare (

In a clinical study involving 1027 patients who received rimantadine at a daily dose of 200 mg, the most common complaints were gastrointestinal and nervous system disorders.

Gross formula

C 12 H 21 N

Pharmacological group of the substance Rimantadine

Nosological classification (ICD-10)

CAS Code

13392-28-4

Characteristics of the substance Rimantadine

Rimantadine hydrochloride is a white crystalline powder with a bitter taste. Soluble in alcohol, difficult - in water. Molecular weight 215.77.

Pharmacology

pharmachologic effect- antiviral.

Blocks the inclusion of the virus into the host cell, inhibits the release of the viral genome in the cell. It has a preventive effect against influenza infection caused by RNA-containing viruses (influenza A virus), has an antitoxic effect against influenza caused by influenza B virus. It is not effective against other acute respiratory viral infections.

It is quickly and quite completely absorbed into the gastrointestinal tract. Metabolized in the liver. Excreted mainly by the kidneys.

Use of the substance Rimantadine

Influenza (prevention during epidemics, treatment in the early stages).

Contraindications

Hypersensitivity, liver disease, kidney disease, thyrotoxicosis, pregnancy, breastfeeding.

Restrictions on use

Epilepsy, cerebral atherosclerosis, children under 1 year of age (safety and effectiveness of use have not been determined).

Use during pregnancy and breastfeeding

Side effects of the substance Rimantadine

From the gastrointestinal tract: nausea, vomiting, epigastric pain, flatulence, anorexia, hyperbilirubinemia.

From the nervous system and sensory organs: headache, dizziness, insomnia, neurological reactions, asthenia, impaired concentration.

Allergic reactions: skin rash, itching, urticaria.

Interaction

Enhances the stimulating effect of caffeine.

Routes of administration

Inside.

Interactions with other active ingredients

Trade names

Name	The value of the Vyshkowski Index ®
	0.0323
	0.0254
	0.0029
	0.0026
	0.0003

Remantadine: instructions for use and reviews

Latin name: Remantadin

ATX code: J05AC02

Active substance: rimantadine

Manufacturer: Moscow Endocrine Plant (Russia), JSC Tatkhimfarmpreparaty (Russia), JSC OFP Obolenskoye FP (Russia), JSC Irbitsky Chemical Plant (Russia), LLC Rozfarm (Russia), Olainfarm (Latvia)

Updating the description and photo: 14.08.2019

Remantadine is an antiviral agent.

Release form and composition

• Capsules: hard gelatin, size No. 0, white; contents – orange powder with a tint from slightly pink to brownish, with white inclusions (10 pcs. in blister packs, 1 or 3 packs in a cardboard pack);
• Tablets: flat-cylindrical, white, chamfered (10 pcs. in blister packs, 2 packs in a cardboard pack).

Active substance: rimantadine hydrochloride – 100 mg in 1 capsule, 50 mg in 1 tablet.

Additional components of Remantadine capsules:

• Excipients: potato starch, stearic acid, lactose monohydrate, sunset yellow dye (Eurolake Sunset Yellow HS (EllO));
• Capsule composition: gelatin, titanium dioxide (E 171).

Excipients of Remantadine tablets: potato starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.

Pharmacological properties

Pharmacodynamics

Rimantadine is active against influenza virus type A (especially type A2). The substance is a weak base, so its effect is due to an increase in the pH of endosomes, which include the vacuole membrane. These endosomes surround viral particles after they enter the cell. In these vacuoles, acidification is prevented, which makes it possible to block the fusion of the viral envelope with the endosome membrane. This prevents the transfer of viral genetic material into the cell cytoplasm. Rimantadine also inhibits the release of viral particles from cells by interrupting the transcription of the viral genome.

Pharmacokinetics

When taken orally, rimantadine is almost completely absorbed from the intestine, but is absorbed rather slowly. The substance binds to plasma proteins by approximately 40%. The volume of distribution in adult patients is 17–25 l/kg, and in children – 289 l/kg. The content of rimantadine in nasal secretions is approximately 50% higher than in blood plasma. Its maximum concentration in blood plasma after a single dose of 100 mg once a day is determined after 6 hours and is equal to 181 ng/ml. If the treatment regimen with Remantadine includes taking it at a dose of 100 mg 2 times a day, the maximum concentration is 416 ng/ml.

Rimantadine is metabolized primarily in the liver and has an elimination half-life ranging from 24 to 36 hours; 75–85% of the dose taken is excreted in the urine mainly in the form of metabolites, and 15% unchanged.

In patients with chronic renal failure, the half-life increases by 2 times. In elderly patients and those suffering from renal failure, rimantadine can accumulate in the body in toxic concentrations if the dose has not been adjusted in proportion to the decrease in creatinine clearance.

Indications for use

According to the instructions, Remantadine is a drug for the early treatment of influenza A.

In tablet form, the drug can also be used for prophylaxis.

Contraindications

• Children under 7 years old - for tablets, up to 14 years old - for capsules;
• Thyrotoxicosis;
• Acute and chronic kidney diseases;
• Acute liver diseases;
• Glucose-galactose malabsorption, lactose intolerance, lactase deficiency;
• Pregnancy and lactation period;
• Individual hypersensitivity to the components of the drug.

Carefully:

• Epilepsy, including a history of;
• Arterial hypertension;
• Diseases of the gastrointestinal tract;
• Liver failure;
• Chronic renal failure;
• Atherosclerosis of cerebral vessels.

Instructions for use of Remantadine: method and dosage

Remantadine should be taken orally after meals: swallow the tablets/capsules whole and drink plenty of water.

• Adults and adolescents over 14 years of age: on day 1 – 100 mg (1 capsule or 2 tablets) 3 times a day, days 2-3 – 100 mg 2 times a day, days 4-5 – 100 mg 1 time per day. On the first day of the disease, a single dose of Remantadine is allowed at a dose of 300 mg (3 capsules or 6 tablets);
• Children 11-14 years old: 50 mg (1 tablet) 3 times a day;
• Children 7-10 years old: 50 mg 2 times a day.

The duration of treatment is 5 days. It is recommended to start taking the drug immediately after the first flu symptoms appear. Remantadine is most effective if treatment is started within the first 24 to 48 hours.

Elderly people, patients with liver failure and chronic renal failure are prescribed 100 mg 1 time per day.

To prevent influenza, adults and children over 7 years of age are prescribed 1 tablet of Remantadine once a day for 10-15 days.

Side effects

Remantadine is generally well tolerated. In rare cases, the following side effects have been reported:

• From the central nervous system: neurological reactions, insomnia, headache, difficulty concentrating, dizziness, anxiety, drowsiness, fatigue, increased excitability;
• From the gastrointestinal tract: loss of appetite, anorexia, dry mouth, flatulence, epigastric pain, nausea, vomiting;
• Allergic reactions: itching, rash, urticaria;
• Other: hyperbilirubinemia.

Overdose

The main symptoms of an overdose of Remantadine are arrhythmia, hallucinations, and nervous agitation. In this case, gastric lavage is performed and symptomatic therapy is prescribed. It is also recommended to resort to measures aimed at maintaining vital functions. Rimantadine is partially eliminated by hemodialysis.

special instructions

During treatment with Remantadine, there is a possibility of exacerbation of concomitant chronic diseases. In elderly people with arterial hypertension, the risk of developing hemorrhagic stroke increases; in patients with a history of epilepsy or simultaneously receiving anticonvulsant therapy, the risk of developing an epileptic seizure increases. In the latter case, the daily dose of rimantadine should not exceed 100 mg.

Prophylactic use of the drug is effective in cases of high risk of disease during an influenza epidemic, contacts with sick people, or the spread of infection in closed groups.

For influenza caused by virus B, rimantadine has an antitoxic effect.

Viruses resistant to the drug may emerge.

Due to the likelihood of developing side effects from the central nervous system during treatment, it is recommended to exercise caution when driving vehicles and performing potentially dangerous types of work that require increased attention and high speed of mental and/or physical reactions.

Drug interactions

Cimetidine reduces the clearance of rimantadine by 18%, paracetamol reduces its maximum plasma concentration by 11%.

Urinary acidifiers (for example, ascorbic acid and ammonium chloride) accelerate the excretion of rimantadine by the kidneys, thereby reducing its effectiveness.

Urinary alkalizers (for example, sodium bicarbonate and acetazolamide), on the contrary, reduce the excretion of rimantadine by the kidneys, thereby enhancing its effect.

Astringents, adsorbents and enveloping agents reduce the absorption of rimantadine.

Remantadine reduces the effectiveness of concomitantly used antiepileptic drugs.

Analogues

Analogs of Rimantadine are: Rimantadine, Rimantadine Actitab, Rimantadine Avexima, Rimantadine-Sti, Olvirem, Polyrem, Algirem, Arbidol, Kagocel, Tamiflu.

Terms and conditions of storage

Store in a place protected from light and moisture, out of reach of children at temperatures up to 25 ºС.

The shelf life of capsules is 2 years, tablets are 5 years.

Remantadine is an antiviral synthetic drug that suppresses strains of viruses. The drug inhibits the release of viruses from cells, i.e. interrupts the transition to the viral genome. In this article we will look at Rimantadine tablets, instructions for their use in adults, and also analyze the indications and contraindications of the drug.

pharmachologic effect

The herbal preparation Rimantadine has a pronounced antiviral effect. The use of tablets at an early stage of infection suppresses strains of virus A and also reduces their synthesis. The pharmacological effect is achieved by suppressing the reproduction of viral cells at the initial stage of infection.

For information! The components of the drug Remantadine have an effect on the tick-borne encephalitis virus.

The components of the medicine are metabolized in the liver, a third of the taken medicine is excreted during urination after 72 hours. In patients suffering from chronic renal failure, the active substance can accumulate in toxic concentrations, provided that the dosage is not adjusted in proportion to the decrease in creatinine clearance. It is worth noting that Remantadine instructions for use of tablets are divided into treatment and prevention of diseases.

Indications and method of use

It is recommended to use an antiviral drug for the prevention and treatment of influenza and viral infections in adults and children. Remantadine tablets are also used to prevent the development of tick-borne encephalitis virus. How much medication to drink is prescribed by the doctor after tests and examination of the patient.

For information! The use of the drug at an early stage of the development of a viral infection helps to suppress the cells of viral strains.

The dosage regimen is described in the instructions for Remantadine tablets, which provide for the prevention of viral infections; the course of treatment lasts one month.

Treatment of influenza and viral diseases in adults

On the first day of illness, it is recommended to take the medicine 3 times a day, the dose is 100 milligrams, on the second and third days it is necessary to take 100 milligrams twice a day, on the fourth and fifth days it is recommended to take 100 milligrams of the medicine once a day. The course of treatment lasts a week.

Prevention of viral infections

Prevention of tick-borne encephalitis is carried out only after the appointment of the attending physician. The drug should be taken after an insect bite. It is recommended to take tablets for 3 days at a dosage of 100 milligrams twice a day.

In case of overdose, you must stop taking the herbal preparation and consult your doctor.

Composition of the drug

The antiviral drug contains the following components:

• active substance - rimantadine hydrochloride;
• additional components - stearic acid, lactose, potato starch, calcium stearate monohydrate, lactose monohydrate.

Tablets are available in white packaging with a dosage of 50 milligrams.

Side effects and contraindications

Improper use of the drug Rimantadine can cause side effects. Each disorder manifests itself in the following symptoms:

• digestive system - flatulence, loss of appetite, pain, dry mouth, attacks of nausea and vomiting;
• nervous system - dizziness, headache, drowsiness, decreased concentration, fatigue, anxiety;
• allergic reaction, itching, rash.

For information! Rarely, side effects manifest themselves in the form of hallucinations, arrhythmia and agitation.

Contraindications to antiviral drugs include:

• chronic and acute form of kidney disease;
• acute liver pathologies;
• hypersensitivity to the active substance;
• period of lactation and pregnancy, regardless of trimester;
• thyrotoxicosis;
• lactose deficiency.

Rimantadine tablets and instructions for their use in adults clearly describe the course of treatment for viruses of various strains, which eliminates side effects.

Patients with liver failure, gastrointestinal diseases, epilepsy, and cerebral atherosclerosis should take the herbal preparation with extreme caution.

You can learn more about taking the herbal remedy Rimantadine from the video

Analogs of Rimantadine tablets

Structural analogues of Rimantadine in terms of the presence of the active substance include the following drugs:

• Amiksin;
• Arbidol;
• Kagocel;
• Ingvirin.

In each similar drug, the administration of the drug may be slightly different, it depends on the dosage of the substance in one tablet.

The herbal preparation Rimantadine is an effective antiviral agent for adults. The main objective of the drug is aimed at suppressing the development of viral cells, as well as treating and preventing tick-borne encephalitis virus. Treatment with the drug is prescribed by a doctor; self-medication or an increased dosage on your own can cause a number of side effects.

Many modern pharmaceutical products for the prevention and treatment of colds and flu often have a relatively high cost. But there is a well-known drug that has been tested by more than one generation. "Remantadine" is an antiviral medicine that will save you from illness during the cold season and will not hurt your wallet.

It should be understood that “Remantadine” is the trade name of the drug. Its active ingredient is rimantadine hydrochloride, or rimantadine.

The drug is produced in two forms:

1. Remantadine tablets. Flat-cylindrical white tablets contain 50 mg of rimantadine hydrochloride, starch, milk sugar, calcium stearate, povidone. The product is sold in blisters or dark glass bottles placed in a cardboard box.
2. Capsules "Remantadine". Contains 100 mg of active ingredient, starch, milk sugar, dye. The capsules themselves consist of gelatin and titanium dioxide, which gives them a white color. The medicine is produced in blisters placed in a cardboard box.

Pharmacological properties and pharmacokinetics

The active component of the drug is rimantadine. Its mechanism of action is to suppress the process of reproduction (replication) of the virus.

When a virus enters a cell, a kind of capsule is formed around it - an endosome. The envelope of the viral particle fuses with the endosome membrane, as a result of which the pathogen RNA enters the space of the host cell. "Remantadine" increases the pH value in the endosome, making it impossible for the interaction of the virus shell and the endosome membrane. The product also prevents the spread of the virus to healthy cells.

The drug "Remantadine" shows pronounced effectiveness against the causative agent of influenza type A. The drug also has a detrimental effect on the tick-borne encephalitis virus, which is most often found in Russia in the spring and summer. For type B influenza, Remantadine helps eliminate toxins.

The active substance of the drug has a special structure, due to which it remains in the blood plasma for a long time. This explains the effectiveness of Remantadine when used to prevent influenza during seasons of high incidence.

Features of the pharmacokinetics of "Remantadine":

• absorption of the drug is slow and occurs in the intestines;
• 6 hours after administration, the maximum quantitative content in the blood plasma is achieved;
• connection with blood plasma proteins – 40%;
• half-life is about 25 hours;
• biotransformation is carried out by the liver;
• excreted by the kidneys.

What does an antiviral drug help with?

Modern experts do not prescribe Remantadine to patients with severe ARVI symptoms. This is explained by the emergence of resistant strains of influenza pathogens and the release of more powerful antiviral drugs.

Despite this, Remantadine is excellent for preventing the flu.

In addition, its use for colds and flu at the stage of initial manifestations often gives positive dynamics. After just 2 days of use, the symptoms of the disease significantly weaken.

Instructions for use of Remantadine

Information on how to take Remantadine is contained in the attached instructions, which should be read before starting treatment. Single and daily doses, duration of administration are determined by the person’s age and purpose of use. Drink the medicine after meals, with a sufficient amount of water. At the first manifestations of the disease, use should be started as soon as possible, preferably within the first 18 hours from the onset of symptoms.

For adults

After a tick bite, the medicine is used according to the recommendations of a specialist. As a rule, for adults, in order to prevent tick-borne encephalitis, Remantadine is prescribed in a dosage of 100 mg. You should drink it twice a day, every 12 hours. Duration of use is 3 days. If necessary, the specialist can increase the course.

For children

For the treatment of influenza in children, the following dosage regimens are prescribed:

• for children 7-10 years old: 50 mg / 2 times a day;
• for children 10-14 years old: 50 mg / 3 times a day.

You must continue to take the product for 5 days.

For adolescents over 14 years of age, the dosage regimen corresponds to that of an adult. In order to prevent illness in children under 14 years of age during the season of high incidence, the duration of taking Remantadine is 2 weeks. It is taken 50 mg once a day.

Remantadine during pregnancy and lactation

Pregnant and lactating women should not take Remantadine.

Studies on laboratory animals have shown that the active substance overcomes the placental barrier and has a detrimental effect on the development of the fetus. Also, after administration, the drug is found in breast milk in significant concentrations.

Drug interactions with other drugs

Having decided to be treated with Remantadine, it is important to take into account the possibility of drug interactions that may arise when taken together with the following groups of drugs:

• medications used for epilepsy (“Remantadine” reduces their therapeutic effect);
• sorbents and drugs that protect the gastrointestinal mucosa (some antacids and herbal medicines that have an enveloping effect) reduce the absorption of the antiviral;
• paracetamol, acetylsalicylic acid reduce the quantitative content of antiviral in the blood;
• cimetidine reduces the rate of elimination of rimantadine from biological fluids;
• ascorbic acid, ammonium chloride increase the rate of excretion of the active substance by the urinary system, reducing its therapeutic effect;
• acetazolamide, sodium bicarbonate (baking soda) enhance the effect of the antiviral, slowing down its excretion by the urinary system.

You should ask your doctor about the possibility of taking Remantadine together with these groups of drugs.

Can I drink alcohol while taking an antiviral drug?

The official instructions for use do not contain information about the interaction of ethanol and rimantadine. Experts do not recommend drinking alcohol during antiviral treatment. Since both of these substances are metabolized in the liver, taking them together significantly increases the load on the organ. As a result, the detoxification function of the liver is impaired, and it is unable to properly neutralize ethanol and metabolize the antiviral agent. Because of this, the likelihood of side effects increases and the negative effect of alcohol on the body increases.

Contraindications, side effects and overdose

Antiviral "Remantadine" is not prescribed for the following conditions:

• liver and kidney diseases;
• lactase deficiency;
• intolerance to the components of the drug;
• disturbances in the absorption of monosaccharides in the gastrointestinal tract;
• hyperthyroidism;
• pregnancy;
• lactation.

Also, Remantadine is not prescribed to children under 7 years of age. For children 1-7 years old, its analogues with a lower dosage are used.

As a rule, the drug is well tolerated. Rarely, side effects affecting certain body systems may occur. The table shows possible adverse reactions.

Side effects of Remantadine

Body system	Undesirable manifestations
Respiratory	bronchospasm; shortness of breath, cough.
Digestive	pain in the epigastric region; dyspeptic disorders; anorexia; increased gas formation; dry mouth; frequent loose stools.
Cardiovascular	increased blood pressure; increased heart rate; cerebrovascular accident; heart block; feeling of heartbeat.
Nervous	headache; clouding of consciousness; impaired concentration; sleep disturbance; fatigue; anxiety; depression; irritability; dizziness; trembling of the limbs or torso; convulsions; hallucinations.

Allergic reactions are possible (in the form of rashes, itchy skin, urticaria), ringing in the ears, perversion of taste and smell. If undesirable effects occur, the issue of using the drug should be discussed with a specialist.

If the recommended doses are exceeded, an overdose of rimantadine is possible, which is characterized by the following symptoms:

• excited state;
• stomach pain;
• sleep disturbance;
• convulsions;
• trembling of limbs.

In case of overdose, gastric lavage is performed and measures are taken to relieve symptoms.

Analogues of the drug Remantadine

In addition to "Remantadine", the following drugs are produced, the active ingredient of which is rimantadine:

1. “Rimantadine”, “Rimantadine Welfarm”, “Rimantadine STI”, “Rimantadine Avexima”, tablets with a dosage of 50 mg.
2. “Rimantadine Kids”, “Orvirem”, “Algirem”, syrups. Forms are prescribed to children over 1 year of age. 1 ml of medicine contains 2 mg of active ingredient.

Analogs of "Remantadine" differ slightly in cost.

Rimantadine hydrochloride is also present in the AnviMax complex product, which is available in capsules, effervescent tablets and powders. It is intended to relieve symptoms and treat early manifestations of colds and flu.