ADS-toxoid (Adsorbed diphtheria-tetanus toxoid) consists of a mixture of purified diphtheria and tetanus toxoids adsorbed on aluminum hydroxide.
The drug contains in 1 ml 60 flocculating units (FU) of diphtheria and 20 antitoxin-binding units (EU) of tetanus toxoids. Preservative - merthiolate at a concentration of 0.01%.
The drug is intended for the prevention of diphtheria and tetanus in children under 6 years of age. ADS-toxoid is administered intramuscularly in a dose of 0.5 ml (single dose).
ADS toxoid is used:
- Children who have had whooping cough (from 3 months to 6 years of age).
- Children who have contraindications to the administration of DTP vaccine.
- Children 4–5 years old inclusive, who have not previously been vaccinated against diphtheria and tetanus.
The vaccination course consists of 2 vaccinations with an interval of 30 days. Reducing the interval is not allowed. If it is necessary to increase the intervals, the next vaccination should be carried out as soon as possible, determined by the child’s health status. Revaccination with ADS toxoid is carried out once 9–12 months after the completed course of vaccination. The first revaccination of children over 6 years of age, as well as subsequent age-related revaccinations, are carried out with ADS-M toxoid.
Vaccinations with ADS toxoid can be carried out simultaneously with vaccinations against polio and other infections in the vaccination schedule.
If a child who has had whooping cough has previously received three or two vaccinations with DPT vaccine, the course of vaccination against diphtheria and tetanus is considered complete. In the first case, revaccination with ADS toxoid is carried out 12–18 months later, in the second case - 9–12 months after the last administration of the drug. If a child has received one vaccination with the DTP vaccine, he is subject to a second vaccination with the DTP toxoid vaccine, followed by revaccination after 9–12 months. Subsequent age-related revaccinations are carried out with ADS-M toxoid.
ADS-toxoid is a weakly reactogenic drug. Some vaccinated people may develop short-term general (fever, malaise) and local (pain, hyperemia, swelling) reactions in the first two days. In extremely rare cases, allergic reactions may develop (Quincke's edema, urticaria, polymorphic rash), a slight exacerbation of allergic diseases.
When a child develops a strong general reaction(increase in temperature to 40°C and above) or post-vaccination complications, further vaccinations with ADS toxoid are stopped. If a child has received two ADS-anatoxin vaccinations, the vaccination course is considered complete. If a child has received one vaccination of ADS-toxoid, then vaccination can be continued with ADS-M-toxoid, which is administered once no earlier than after 3 months. In both cases, the first revaccination is carried out with ADS-M toxoid 9–12 months after the last vaccination. Subsequent ones are carried out at the age of 7–14 years with ADS-M-anatoxin.
When the temperature rises above 38.5°C in more than 1% of vaccinated people, or when severe local reactions(swelling of soft tissues with a diameter of more than 5 cm; infiltrates with a diameter of more than 2 cm) in more than 4% of vaccinated people, as well as with the development of severe post-vaccination complications Vaccinations with this series of drugs are stopped.
There are no permanent contraindications to the use of ADS toxoid. Tactics of vaccination with ADS-anatoxin for premature infants and children who have had acute diseases, children with chronic diseases, as well as with mild forms of respiratory and allergic diseases, the tactics of immunization with the DTP vaccine are similar.
Immunodeficiencies, HIV infection, as well as maintenance course therapy. are not contraindications to vaccination. Routine vaccinations with ADS toxoid are carried out no earlier than 1 month after vaccinations against other infections.
ADS-toxoid is produced in ampoules of 0.5 ml (one vaccination dose) and 1.0 ml (two vaccination doses). The drug is stored in dry, dark place at a temperature of 6±2 °C. Transportation is carried out by all types of covered transport under the same conditions.
The shelf life of ADS-anatoxin is 3 years.
Sorbed on. Preservative – merthiolate.
Release form
Colorless liquid with a slightly yellowish or white precipitate.
pharmachologic effect
Pharmacodynamics and pharmacokinetics
After administration, Diphtheria-Tetanus Anatoxin (ADS-toxoid) helps to develop persistent immunity To tetanus And diphtheria , preventing the occurrence of these diseases. It is a solution with weakened bacterial toxins. These substances, entering the body, trigger a series of biochemical reactions that activate the formation of the pathogen.
However, the drug, as a rule, does not provoke the development of the disease itself. Its use, on the contrary, helps suppress infections , so that foreign agents entering the body do not cause disease.
IN medical institutions In addition, specialists use -anatoxin. It also promotes the production immunity against pathogens diphtheria And tetanus , but its content is reduced.
Indications for use
The drug is used for the following purposes:
- Planned revaccination patients from 7 years old.
- Injections patients over 7 years of age who have already had vaccinations from diphtheria And tetanus .
- Vaccination patients for whom there is no reliable data on vaccinations from tetanus And diphtheria .
Contraindications
It is contraindicated to do injections with exacerbation of chronic diseases and. When acute infectious diseases vaccinations are given 2-4 weeks after recovery.
Side effects
In rare cases, after injections observed painful sensations at the injection site, swelling , increased body temperature, exacerbation, general weakness, hyperemia , .
Due to the risk of developing severe allergic manifestations After vaccination, patients should be monitored for 30 minutes. In venues injections must be provided antishock therapy .
If allergic reactions occur in severe forms course of injections is interrupted.
Instructions for use (Method and dosage)
ADS toxoid is administered in a single dose of 0.5 ml intramuscularly into the anterior outer part of the thigh or under the shoulder blade, deep subcutaneously.
Before the injection, the ampoule with the drug should be shaken well.
Conduct planned age-related revaccination at 7 and 14 years old, and then vaccinations done every 10 years.
Course of injections includes two vaccinations, the interval between which is 30-45 days. This interval cannot be shortened. If it needs to be increased, the next vaccination is given as soon as possible.
After the completed one-time vaccinations first revaccination carried out after 6-9 months. Second revaccination must be carried out after 5 years.
If a negative reaction to ADS toxoid develops, once inject ADS-M toxoid after at least three months. In cases where unwanted side effects appeared on the second vaccination , course of injections don't continue.
For vaccinations adult patients who have not previously been reliably vaccinated against diphtheria And tetanus use ADS-M toxoid. Make two vaccinations with an interval of 30 days. Revaccination carried out after 6-9 months.
Overdose
Data on overdose are not provided.
Interaction
ADS-M-anatoxin injected in a month or together with polio vaccine .
Terms of sale
This drug is not sold in pharmacies. It is supplied only to medical institutions.
Storage conditions
It is necessary to store ampoules in a dry and dark place. Optimal temperature about 6°C. The drug should not be frozen.
Best before date
ADS-anatoxin should not be stored in closed ampoules for longer than 36 months.
Reviews: 20
In the understanding of many people, vaccinations should be carried out once or at most three times. This is enough to develop immunity. But there are vaccines that are given constantly, until old age at certain intervals. Such a vaccine is ADS-M - a vaccine against diphtheria and tetanus.
What kind of injection is this and why do it throughout your life? What is the ADS-M vaccine for and how often is it given?
Why get vaccinated against diphtheria and tetanus?
Several decades ago, the words diphtheria and tetanus terrified not only people whose family had such illnesses. Doctors were afraid to diagnose these particular diseases. They are from the category of those for which it is much easier to prevent than to cure. If a person is lucky enough to survive one of these diseases, then complications often bother him for the rest of his life. Nowadays, cases of morbidity are becoming less common thanks to vaccination against diphtheria and tetanus.
Diphtheria and tetanus belong to the group of acute bacterial infectious diseases. The source of infection is a sick person, and in the case of tetanus, animals can also be carriers of the infection.
Diphtheria affects the upper Airways. Clinical manifestations with the following:
- slight increase temperature, weakness, increase cervical lymph nodes;
- sore throat, swelling of the neck tissue, difficulty swallowing food, including liquid food;
- inflammation of the pharyngeal mucosa, enlarged tonsils;
- The distinctive prognostic signs of the disease are the appearance of plaque on the tonsils, which can spread to neighboring tissues.
Complications of diphtheria: heart damage, paralysis of neck muscles and soft tissues, dysfunction nervous system. In severe and advanced cases - death. At what age do you get vaccinated against diphtheria? The introduction of the first complex vaccine begins three months after the birth of the child.
The symptoms of tetanus differ because the nervous tissue is more affected. The disease is characterized by:
- elevated temperature, weakness;
- tension and spastic contractions of the facial muscles;
- muscle tension in the neck, torso and limbs;
- difficulty breathing;
- death may occur due to sharp spasm respiratory muscles.
Both diseases affect nerve tissue, they cannot be treated with ordinary and even super-strong antibacterial drugs. Diseases are much easier to tolerate or cases occur less frequently if vaccination is completed in a timely manner. For this purpose, children and adults are vaccinated with ADS-M. According to the calendar, the first injections (DTP - complex vaccine with whooping cough) are carried out at 3, 4.5 and 6 months. The first revaccination should be at 18 months. The second revaccination with ADS-M should be at 7 years of age, then at 14. After which it is repeated every 10 years throughout life. Age is not a limitation for the prevention of such serious illnesses- Diphtheria and tetanus can affect a person at any time in his life.
What kind of vaccine is ADS-M?
Various options There are so many prophylactics for diphtheria and tetanus that you can’t help but wonder: is each of them necessary? What is the composition of the ADS-M vaccine and what does each symbol mean? One dose of the ADS-M vaccine - 0.5 ml of substance contains:
- 5 units of diphtheria toxoid;
- 5 tetanus toxoid binding units;
- Excipients: thiomersal, formaldehyde, aluminum hydroxide.
The usual packaging of ADS-M contains ampoules of 1 ml, that is, each contains 10 units of each toxoid.
What is different about this particular vaccine? ADS - these symbols indicate purified, adsorbed liquid diphtheria-tetanus toxoid. Under capital letter“M” refers to reduced antigen content.
The ADS vaccine, for example, contains 60 units of diphtheria and 20 units of tetanus toxoids. That is, the number of active units against each disease is significantly increased. How else is ADS different from ADS-M? These are indications for use. For each of these drugs there are clear criteria for administration.
ADS-M instructions
The ADS-M vaccine is produced in the form of a yellowish-white suspension. Each ampoule contains 1 ml of the substance - this is a double dose of toxoid. According to the instructions for the ADS-M vaccine, it is used:
- for the prevention of diphtheria and tetanus in children from the age of six;
- used in adolescents and adults every 10 years;
- the ADS-M vaccine is administered to adults who have not received a vaccine in the last 20 years;
- in rare cases, ADS-M vaccination is given as a replacement of DTP or ADS vaccines in children with severe reactions or post-vaccination complications to these drugs;
- children of four years of age who have not previously received DPT.
The ADS-M vaccine is a drug that is used to support immunity throughout life.
Where is the ADS-M vaccine given? According to the new instructions, the drug is administered intramuscularly into the anterior outer part of the thigh or deep subcutaneously into the subscapular region (adolescents and adults).
Contraindications for the use of ADS-M
There are both permanent and temporary contraindications for ADS-M vaccination.
TO permanent contraindications include:
- a pronounced reaction to the ADS-M vaccine during its previous administration;
- complications after the first or subsequent vaccinations.
Temporary contraindications are as follows.
In the event that the vaccination schedule has been disrupted, a half dose of the drug is administered, and then a revaccination is given - RV2 a month later and RV3 at least 30–45 days after the previous one.
Reaction to ADS-M vaccination
After administration of toxoid, some local or general reactions are possible.
All the most serious complications according to the type of damage to the nervous system, inflammation of the meninges and collapse could occur in the case of administration of the whooping cough vaccine - DTP.
ADS-M is well tolerated; complications and reactions to this vaccine occur due to improper behavior of the person himself. They are possible when scratching the injection site, if a person, contrary to the ban, wet it, visited the site within two days after vaccination large cluster of people. In such cases, the reaction may not have occurred to the vaccine itself. The most frequently asked question to doctors is whether it is possible to wash after vaccination against diphtheria and tetanus? In general, it is possible, but not possible, to wet the injection site of the toxoid.
Similar vaccines for diphtheria and tetanus
There are several analogues of the diphtheria and tetanus vaccine:
- ADS-M anatoxin (Russia);
- "Imovax D.T. Adult" (France);
- “D.T. Wax" (France).
Complications for any of these vaccinations are minimal and often depend on the human factor. All of them are well tolerated. The substances include the same toxoids, but the stabilizers may be different.
Let's summarize. When should you get the ADS-M vaccine? To build immunity against diphtheria and tetanus. All adults are vaccinated starting from the age of 14 or 16 (old calendar) and every 10 years in the absence of contraindications. Any unvaccinated person is at risk - these people not only can get sick themselves, they will infect other people, including children who still have weak immunity. One ADS-M vaccination will not easily get rid of yet another paperwork in the clinic, it may possibly save a loved one from death!
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Why does the article omit information about the presence in the ADS-M vaccine of the merthiolate preservative, which is poisonous? chemical compound, especially neurotoxic in combination with the aluminum contained in the vaccine?
Tatyana Vitalievna, the article talks about merthiolate, only it is designated in it under a different name trade name- Thiomersal. It is used as a preservative and its amount in the vaccine is tiny - 0.05 mcg (microgram), the effect on the body is negligible.
Hello, help me figure it out, the child was treated with Ads 2 times before the age of one year, now the child is 1 year and 10 months old, the pediatrician said that Ads should be done again. Is this true and how many times should I do it? I thought that it was already done at the age of 7.
The child was given ADMS at school, notified in September, vaccinated almost two months later in November, the daughter recently suffered from ARVI, had herpes on her lips, and despite all this, she was vaccinated. Now we have conjunctivitis, a sore throat, the temperature reaches 40.5, an increase in the number of herpes, and in childhood we also had complications after DPT vaccinations. What to do, where to go to have your child examined, to get good treatment!
Good afternoon Very useful article, thank you. It so happened that we were mistakenly given both Pentaxim and our Russian DPT vaccine on the same day. The child tolerated it normally, tell me how to proceed with the vaccination, and what consequences there may be in the future due to the double dose of DPT and different drugs, thank you in advance.
What to do? A 56-year-old woman, after a tetanus vaccination, developed angioedema and a temperature of 38 within an hour; on the 11th day she developed tachycardia, fever, weakness and drowsiness. Today, on the 15th day after vaccination, hives all over the body. Should I do the rest of the vaccination or is it dangerous to life and health?
Svetlana, you should definitely inform your doctor about such a reaction, and he will decide whether or not you can do the “remaining part of the vaccination.” Although it is not clear what this “remaining part” is, since this vaccination in adulthood is done once every 10 years.
Roman, thank you for your response. Vaccination in three steps: the first stage is a test, the second (in half an hour) is the vaccination itself, and they also told you to come back in a month for the third vaccination.
“Insignificant” influence? Is it methylmercury, aluminum hydroxide and formaldehyde? What does reference literature tell us about them? A..., are especially toxic, even when inhaled and eaten, cause necrosis skin(death of skin). Preserved lizards, snakes and others are stored in formaldehyde. visual aids. And when direct hit into the bloodstream - and from there directly into the brain - methylmercury, aluminum hydroxide and formaldehyde? What is going to be there? Where can you read about this? For example, links to studies, experiments on rabbits, vaccinated for 3-5 generations in a row. Do you have them ;)? And autism (brain damage), you say, has nothing to do with vaccinations?
I personally checked the antibody titer - it turned out to be very high - while “re-vaccination” is not only not required, but CONTRAINDICATED! The analysis is not very expensive. And health is priceless!
Contraindicated until you or your family are sick with diphtheria and suffer from it. If you are not able to read authoritative foreign sources (oh yes... Further cut out by the site administrator - insult, incitement to hatred and enmity), but also simply calculate the probability of dying from a sore and getting any complications from vaccination (spoiler: the chances are one in several hundred thousand) - that’s where you’re headed.
Inna, yes, in Russia they “go crazy” - I will/won’t get vaccinated. It is clear that the situation in Ukraine is different and there are simply no vaccines - I would be glad to supply them, but there is nothing or it is very expensive)))
Please don't argue! There is definitely harm. And many children remain disabled with impaired brain function. It's just hidden! They don't advertise. There is a risk. And before getting vaccinated, you need to take tests, examine the child, and collect a complete medical history. They didn’t just look down your throat and send you for vaccination. And by the way, please note that the vaccinations that are administered to children have not previously been experimented on animals.
Maya, why can’t we argue? For example, “a lot of children become disabled” - how many exactly? There is evidence that statistics side effects hiding? Where does the data come from that experiments are not being carried out?
I am interested in the time interval between the first DPT revaccination and the second DPT-M revaccination.
Maya, people with brain disorders are born, not after vaccination. And the reason is the total alcoholism of our fellow citizens. For some reason this doesn’t stop anyone from using it.
What total alcoholism, what nonsense! You are busting your ass over vaccinations because you were lucky enough not to face any real problems after it! After the DPT revaccination, my son started having problems. Born healthy, 9 points on the scale, developed wonderfully (we lead correct image life, we don’t smoke or drink with my husband), BUT after it the child lost all acquired skills, he stopped talking!!! We were diagnosed with autism at age 2! And you don’t need to write to me that he was born this way, he was healthy BEFORE the vaccination. Doctors shrug their shoulders and say, well, you are one of the 3% of children who were affected by the vaccine in this way. So those who are tearing their throats out here and expressing bewilderment as to why we are “getting crazy,” I want to say, you live under the slogan “is your child not disabled yet? Then we go to you!"
As a mother, I wish you with all my heart that you do not fall into these 3%... You can’t even imagine what I had to experience. Ingeborga dapkunaite (?), this is not a childhood vaccine... Children are given DPT. Are you sure you're not making things up?
I believe that vaccinations should be done, but not all in a row, based on various factors. For example, I don’t see the point in sculpting Ads-m vaccination, especially in adulthood, if for example a person received open wound, somewhere working in the field he should do antitetanus serum, if there are no outbreaks of diphtheria in the region, why should they be given to children over seven years old... I vaccinate my son, because we travel a lot to Asian countries, here you will never know who you came into contact with at the airport and what diseases you can pick up in India , V in this case“It’s better to be safe than sorry.” Regarding complications, there is a lot of talk about autism now, and the statistics are disappointing, and it is not clear whether this condition manifests itself after vaccinations or whether it is still congenital and the vaccination already spurs the disease. Regarding preservatives - they, of course, contain a lot active ingredients and you need to know about this, although they are in microscopic doses, and some of the commentators are already poisoning rabbits with formaldehyde - they also compared, if you live in the city, you are poisoned every day much more, but for some reason you are only worried about the vaccine... Regarding statistics As for side effects, I personally believe that no one keeps statistics, side effects, I won’t even talk about a banal increase in temperature - this is just the norm, considering that it is a disease that is being administered, not vitamins. But there are complications and this depends, first of all, on the quality of the vaccination. My friend’s child couldn’t get up for two days and was screaming, who recorded this for statistics? They just installed a medical outlet and that’s it... And I’m against vaccinations from birth, even in the maternity hospital they diagnose hepatitis - it’s unlikely that in a normal family a child will encounter this disease in infancy, and if he breastfeeding he already has protection. I gave the first vaccination at 8 months, although it could have been a couple of months later, based on the fact that the child begins to walk and come into contact with environment more actively... Those who categorically refuse vaccinations are still advised to do them in cases where there are outbreaks of one of the diseases in the region or are planning to travel (before the trip, the vaccination must be done very well in advance) because this fatal diseases that are difficult to treat...
In principle, I am in favor of vaccinations, but of course you need to look at your own and your child’s condition. I gave my daughter all the vaccinations, but not our Russian ones, because the first DTP given at the clinic, due to my ignorance, even then caused an unpleasant reaction, as described above - the child was simply replaced, for a week I didn’t know what to do with it and where run, the child did not eat, did not sleep, cried, constantly sat in our arms, so we gave the rest of the vaccinations Pentaxim and there were no more such reactions.
Diphtheria-tetanus toxoid
Composition and release form of the drug
1 ml (2 doses) - ampoules (10) - cardboard packs.
pharmachologic effect
Indications
- prevention of diphtheria and tetanus in children from 6 years of age, adolescents and adults.
Contraindications
- hypersensitivity;
- pregnancy.
Dosage
IM into the upper outer quadrant of the buttock or the anterior outer part of the thigh or deep subcutaneously (adolescents and adults) into the subscapular area in a single dose of 0.5 ml.
Before administration, the drug must be shaken thoroughly until a homogeneous suspension is obtained.
For planned age-related revaccinations at 7 and 14 years of age, then every subsequent 10 years without age limitation - once.
For vaccination children 6 years and older, previously unvaccinated against diphtheria and - the vaccination course consists of two vaccinations with an interval of 30-45 days. Reducing the interval is not allowed. If it is necessary to increase the interval, the next vaccination should be carried out as soon as possible. The first revaccination is carried out 6-9 months after the completed vaccination once, the second revaccination is carried out at an interval of 5 years. Subsequent revaccinations are carried out every 10 years without age restrictions.
As a replacement for diphtheria-tetanus-pertussis vaccine (DPT vaccine) or diphtheria-tetanus toxoid with standard concentration of antigens (ADT toxoid) in children with strong general reactions(hyperthermia up to 40°C and above) or post-vaccination complications to these drugs. If the reaction develops to the first DTP vaccination(ADS), then ADS-M toxoid is administered once no earlier than 3 months later; if a reaction develops to the second vaccination, then the course of vaccination against diphtheria and tetanus is considered completed. In both cases, the first revaccination with ADS-M toxoid is carried out after 9-12 months. If a reaction has developed to the third DPT vaccination (ADS), the first revaccination with ADS-M toxoid is carried out after 12-18 months.
To carry out a course of vaccination adults, who have not previously been reliably vaccinated against diphtheria and tetanus, undergo a full course of immunization (two vaccinations with ADS-M toxoid with an interval of 30 days and revaccination after 6-9 months).
IN foci of diphtheria preventive vaccinations carried out in accordance with the instructions and methodological documents of the Russian Ministry of Health.
Side effects
Rarely(in the first two days): hyperthermia, malaise, local reactions (pain, hyperemia, swelling); V isolated cases – angioedema, urticaria, polymorphic rash, minor exacerbation of allergic diseases.
special instructions
Persons who have suffered acute diseases are vaccinated 2-4 weeks after recovery. In mild forms of the disease, vaccinations are allowed after the clinical symptoms disappear.
Patients with chronic diseases are vaccinated upon achieving complete or partial remission. Children with neurological disorders vaccinated after progression of the process has been ruled out. Sick allergic diseases vaccinations are carried out 2-4 weeks after the end of the exacerbation, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy.
Immunodeficiencies, HIV infection, as well as maintenance course therapy (including GCS) are not contraindications to vaccination.
In order to identify contraindications, on the day of vaccination, the doctor conducts a survey of parents and examines the vaccinated with mandatory thermometry. At vaccinations for adults preliminary selection of persons to be vaccinated is allowed, with their questioning medical worker on the day of vaccination, those administering the vaccination. Persons temporarily exempt from vaccination must be monitored and registered and vaccinated in a timely manner.
If epidemiologically necessary, ADS-M toxoid can be administered against the background of an acute illness. When strong reaction not the previous dose of this drug, a repeat dose is administered against the background of the use of GCS (orally - 1-1.5 mg/kg/day the day before and immediately after vaccination).
Persons vaccinated with tetanus toxoid are vaccinated with diphtheria toxoid between revaccinations.
ADS-M toxoid can be administered after a month or simultaneously with polio vaccine and other vaccines national calendar vaccinations.
Considering the possibility of developing immediate allergic reactions in particularly sensitive individuals, vaccinated individuals must be provided with medical supervision for 30 minutes. Vaccination sites must be provided with anti-shock therapy.
Persons who gave for introduction ADS-M toxoid severe forms allergic reactions, routine vaccinations with the drug are stopped.
Not suitable for use in ampoules with damaged integrity, lack of markings, if changed physical properties(discoloration, presence of unbreakable flakes), improper storage.
The opening of the ampoules and the vaccination procedure are carried out when strict adherence rules of asepsis and antiseptics. The drug cannot be stored in an opened ampoule.
The administration of the drug is registered in the established accounting forms, indicating the batch number, expiration date, manufacturer, and date of administration.
Pregnancy and lactation
Use in childhood
Application is possible according to the dosage regimen.
Children with neurological disorders are vaccinated after progression of the process has been ruled out.
Instructions for medical use medicine
Diphtheria-tetanus toxoid purified adsorbed liquid (ADS-anatoxin)
Trade name of the drug
Diphtheria-tetanus toxoid purified adsorbed liquid (ADS-anatoxin)
International nonproprietary name
Dosage form
Suspension for intramuscular injection, 0.5 ml/dose
One vaccination dose (0.5 ml) contains
active substances: diphtheria toxoid 30 flocculating units -Lf (specific activity not less than 1500 Lf/mg protein nitrogen), tetanus toxoid 10 binding units -EC (specific activity not less than 1000 EU/mg protein nitrogen),
excipients: aluminum hydroxide no more than 0.55 mg, merthiolate (preservative) from 40 to 60 mcg, formaldehyde no more than 50 mcg.
Description
The suspension is yellowish-white in color, separating upon settling into a clear supernatant liquid and a loose sediment that completely breaks up when shaken.
Pharmacotherapeutic group
Antibacterial vaccines. Tetanus toxin in combination with diphtheria toxin.
PBX code J07AM51
Pharmacological properties
Pharmacokinetics
No data available.
Pharmacodynamics
ADS - toxoid consists of a mixture of purified diphtheria and tetanus toxoids adsorbed on aluminum hydroxide.
Causes the formation of specific antitoxic immunity against diphtheria and tetanus.
Indications for use
Prevention of diphtheria and tetanus in children under 6 years of age inclusive:
children who have had whooping cough since 3 months,
children who have contraindications to the administration of DTP vaccine,
children aged 4-5 years inclusive, not previously vaccinated against diphtheria and tetanus
Directions for use and doses
ADS toxoid is administered intramuscularly into the anterior outer part of the thigh for children under 1 year of age or into the deltoid muscle of the shoulder for older children at a dose of 0.5 ml. Before vaccination, the ampoule must be thoroughly shaken to obtain a homogeneous suspension.
The vaccination course consists of two vaccinations with an interval of 30 days. Reducing the interval is not allowed. If it is necessary to increase the interval, the next vaccination should be carried out as soon as possible, determined by the child’s health condition. Revaccination with ADS toxoid is carried out once 6-12 months after the completed course of vaccination.
The first revaccination of children over 6 years of age, as well as subsequent age-related revaccinations, are carried out with ADS-M toxoid.
If a child who has had whooping cough has previously received three or two vaccinations with DTP vaccine, the course of vaccination against diphtheria and tetanus is considered completed. In the first case, revaccination with ADS toxoid is carried out 12-18 months later, and in the second case, 9-12 months after the last administration of the drug. If a child has received one vaccination with DPT vaccine, he is subject to a second vaccination with DPT toxoid, followed by revaccination after 9-12 months. Subsequent age-related revaccinations are carried out with ADS-M toxoid.
Side effects
ADS-toxoid is a weakly reactogenic drug.
Possible in the first two days
Fever, malaise
Soreness, hyperemia, swelling at the injection site
In isolated cases
Quincke's edema
Hives
Polymorphic rash
Exacerbation of allergic diseases
Contraindications
Hypersensitivity to the components of the drug
Acute infectious diseases or exacerbation of chronic diseases
Increased body temperature above 37°C
Seizure syndrome or epilepsy
Allergic reaction to previous administrations of the drug
Drug interactions
ADS toxoid can be administered a month later or simultaneously with the polio vaccine.
special instructions
Children who have suffered acute illnesses are vaccinated 2-4 weeks after recovery. In mild forms of disease (rhinitis, mild hyperemia of the pharynx, etc.), vaccination is allowed after the disappearance of clinical symptoms.
Patients with chronic diseases are vaccinated upon achieving complete or partial remission. Children with neurological changes are vaccinated after progression of the process has been ruled out. Patients with allergic diseases are vaccinated after 2-4 weeks of remission, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm, etc.) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy. Immunodeficiencies, HIV infection, as well as maintenance course therapy, including steroid hormones and anticonvulsants are not contraindications to vaccination.
In order to identify contraindications, on the day of vaccination, the doctor conducts a survey of parents and examines those vaccinated with mandatory thermometry. Children temporarily exempt from vaccination must be monitored and registered and vaccinated in a timely manner.
If a child develops a strong general reaction (temperature rise to 40 °C or higher) or a vaccine complication, further vaccinations with ADS toxoid are stopped. If a child has received two vaccinations with ADS-toxoid, the vaccination course is considered complete; if the child has received one vaccination with ADS-toxoid, then vaccination can be continued with ADS-M-toxoid, which is administered once no earlier than 3 months later. In both cases, the first revaccination is carried out with ADS-M toxoid after 9-12 months. after the last vaccination.
Subsequent revaccinations are carried out according to the national vaccination calendar.
When the temperature rises above 38.5 °C in more than 1% of vaccinated people or when severe local reactions occur (swelling of soft tissues with a diameter of more than 5 cm, infiltrates with a diameter of more than 2 cm) in more than 4% of vaccinated people, as well as with the development of severe post-vaccination complications of vaccination with this drug the series is stopped.
Considering the possibility of developing immediate allergic reactions in particularly sensitive individuals, vaccinated individuals must be provided with medical supervision for 30 minutes. Vaccination sites must be provided with anti-shock therapy.
The drug is not suitable for use in ampoules with damaged integrity, lack of labeling, changes in physical properties (change in color, presence of unbreakable flakes), expired, or improper storage.
The opening of ampoules and the vaccination procedure are carried out in strict compliance with the rules of asepsis and antiseptics. The drug cannot be stored in an opened ampoule.
The administration of the drug is registered in the established accounting forms, indicating the batch number, expiration date, manufacturer, and date of administration.