Baralgin is combined remedy analgesic and antispasmodic action.
pharmachologic effect
The composition of Baralgin includes metamizole sodium, fenpiverinium bromide, pitofenone hydrochloride - all of them together lead to an increase in pharmacological action each other.
Metamizole sodium acts as an antipyretic and analgesic. Pitophenone hydrochloride in the composition of Baralgin has a myotropic effect on smooth muscles, and fenpiverinium bromide supplements it.
Release form
Baralgin is produced in tablets and suppositories. Baralgin's solution is also produced in ampoules - for intramuscular, intravenous injections.
According to the instructions, Baralgin's tablet contains 0.5 g of analgin, 0.005 antispasmodic (the action of which is similar to that of papaverine) and 0.0001 g of a ganglionic blocker. Accordingly, in a 5 ml ampoule of Baralgin - 2.5 g / 0.01 / 0.0001 g, and the composition of Baralgin in candles - 1 / 0.01 / 0.0001 g.
Indications for use Baralgin
Baralgin is used for moderate and mild pain syndrome with spasms of smooth muscles: intestinal, renal, biliary colic, spasms of the bladder, ureter.
An indication for the use of Baralgin is also biliary dyskinesia, postcholecystectomy syndrome, chronic colitis, diseases of the pelvic organs, algomenorrhea.
Baralgin is also effective for short-term therapy of myalgia, sciatica, arthralgia, neuralgia, and also as aid when eliminating pain syndrome after diagnostic procedures and surgical interventions.
Instructions for use Baralgin
Baralgin tablets are prescribed for children over 15 liters. and adults one by one - two pieces two or three rubles / day. For children from 12-14 years old, a single dose of Baralgin is one tablet (maximum allowable dose- 1.5 tab. four r / day). Children 8-11 years old take half a tablet (maximum 4 tablets per day). From 5 to 7 l. - also half a tablet, and maximum dose- 2 tablets per day. According to the instructions, Baralgin tablets are swallowed with a small amount of liquid, without chewing.
Intravenous and intramuscular application Baralgin
Adults and children over 15 years old. in the presence of severe acute colic slowly inject 2 ml intravenously (within one minute - one ml.). If necessary, the introduction is repeated after six to eight hours.
Baralgin is prescribed intramuscularly in two to five ml. 2-3r / day, while the daily dose cannot exceed 10ml. The course of treatment is usually five days.
The dosage of Baralgin for children, for intravenous, intramuscular administration is calculated depending on their weight. For a child weighing from 5 to 8 kg (approximately 3-11 m) - Baralgin is administered only intramuscularly - 0.1-0.2 ml; 9-15kg (one, two years) - intravenously - 0.1-0.2 ml, and intramuscularly - 0.2-0.3 ml; 16-23 kg (three, four years) - intravenously - 0.2-0.3 ml, and intramuscularly - 0.3-0.4 ml; 24-30 kg (five to seven years) - intravenously - 0.3-0.4 ml, and intramuscularly - 0.4-0.5 ml; 31-45kg (from 8 to 12l) - intravenously - 0.5-0.6ml, and intramuscularly - 0.6-0.7ml; children from 12 to 15 liters - intramuscularly, intravenously - 0.8-1 ml.
Before the injection, the ampoule with Baralgin must be held a little in the hand to heat it up.
Side effects
When using Baralgin, allergic reactions, impaired renal function, anuria, interstitial nephritis, oliguria, proteinuria, red staining of urine are possible.
It is also possible to reduce pressure, sweating, agranulocytosis, thrombocytopenia, leukopenia, dry mouth, tachycardia, accommodation paresis, difficulty urinating. Sometimes infiltrates are observed at the injection site of Baralgin.
Contraindications to the use of Baralgin
As indicated in the instructions, Baralgin is not prescribed in the presence of hypersensitivity to it, with severe renal and liver failure, with oppression of bone marrow hematopoiesis, tachyarrhythmia, severe angina pectoris, deficiency of glucose-6-phosphate dehydrogenase, chronic decompensated heart failure,
prostatic hyperplasia, intestinal obstruction, angle-closure glacoma. It is also impossible to use Baralgin with collapse, pregnancy, lactation, megacolon.
Baralgin is not administered intravenously to children under 3 months of age, and if the child's weight is less than 5 kg.
Do not give Baralgin tablets to children under 5 liters.
With caution, Baralgin is prescribed for the aspirin triad, bronchial asthma, hepatic and renal failure, sensitivity to other non-steroids, and a tendency to hypotension.
Sincerely,
Composition and form of release
1 ml solution for injection contains metamizole sodium 500 mg; in ampoules of 5 ml, a box of 5 ampoules.
1 tablet - 500 mg; in a blister 10 pcs., in a box of 10 blisters.
pharmachologic effect
pharmachologic effect- anti-inflammatory, antipyretic, antispasmodic, analgesic.Blocks cyclooxygenase and reduces the synthesis of PG.
Pharmacokinetics
After oral administration, it is hydrolyzed in the gastrointestinal tract with the formation of an active metabolite - 4-methylaminoantipyrine (4-MMA), which is absorbed in the liver into 4-aminoantipyrine (4-AA), as well as pharmacologically inactive metabolites. After oral administration of 1 g of metamizole, 58% of 4-MMA and 48% of 4-AA bind to plasma proteins. The effective therapeutic plasma concentration of 4-MMA is reached after 20-40 minutes, C max - after 2 hours.
Indications for Baralgin ® M
Pain syndrome of mild to moderate intensity (headache and toothache, neuralgia, pain in sciatica, osteochondrosis, arthritis, menalgia), spasms of smooth muscles (renal colic, biliary colic, intestinal colic), feverish conditions with infectious and inflammatory diseases (as part of combination therapy).
Contraindications
Hypersensitivity to pyrazolones (including metamizole isopropylaminophenazone, propyphenazone and phenazone-containing agents, phenylbutazone). Acute hepatic porphyria, congenital deficiency of glucose−6-phosphate dehydrogenase.
Use during pregnancy and lactation
Contraindicated in the I and III trimesters of pregnancy. Use in the II trimester - only on strict medical indications. Breast-feeding is contraindicated within 48 hours after taking Baralgin M.
Side effects
Agranulocytosis, leukopenia, thrombocytopenia, a sharp drop in blood pressure, transient disorders kidney function (oliguria or anuria, proteinuria), interstitial nephritis, allergic and immunopathological reactions (urticarial rashes on the skin, conjunctiva, mucous membranes in the nasopharynx; Stevens-Johnson syndrome, Lyell's syndrome, anaphylactic shock).
Interaction
Reduces the concentration of cephalosporin in the blood, enhances the effect of alcohol.
Dosage and administration
In / in, in / m. For adults and adolescents over 15 years of age, a single dose is 2-5 ml (in / in or / m), the daily dose is up to 10 ml. In / in the introduction of a single dose in excess of 2 ml (1 g) is possible only after careful statement of indications. For children and infants daily dose set taking into account body weight (infants 5-8 kg - 0.1-0.2 ml / m; children 9-15 kg - 0.2-0.5 ml / in or / m; children 16- 23 kg - 0.3-0.8 ml IV or IM; children 24-30 kg - 0.4-1 ml IV or IM; 31-45 kg - 0.5-1, 5 ml in / in or / m; 46-53 kg - 0.8-1.8 ml / in or / m. In / in the introduction of the drug should be carried out slowly (1 ml for 1 min), in the position of the patient lying down and under the control of blood pressure, heart rate and respiration. injection solution should be at body temperature.
Inside, adults - 500-1000 mg 4 times a day. The maximum single dose is 1 g, the daily dose is 3 g.
Precautionary measures
Should be respected special care with arterial hypotension (systolic blood pressure below 100 mm Hg); in situations characterized by unstable indicators of systemic hemodynamics ( acute infarction myocardium, multiple trauma, incipient shock); in patients with a history of peripheral blood disorders (for example, those who received cytostatic agents) or hypersensitivity reactions to medicinal substances(food, preservatives, furs, hair dye) suffering from bronchial asthma and/or chronic infectious and inflammatory diseases respiratory tract, With hypersensitivity to any NSAIDs and antipyretic analgesics (the threat of developing bronchial asthma and shock); in infants during the first 3 months of life or weighing less than 5 kg (increased risk of developing impaired renal function). It is not recommended to combine with drugs, causing reactions intolerance (radiocontrast agents, plasma-substituting solutions, penicillins). In the event of an unexpected deterioration general condition patient (fever, inflammation of the mucous membranes of the oral cavity, nose and pharynx, increase in ESR) should be canceled immediately. In case of anaphylactic shock, it is required to inject intravenously (slowly) a 0.1% solution of adrenaline (if necessary, repeatedly at intervals of 15-30 minutes), then a glucocorticoid, antihistamines, carry out the replacement of blood volume, mechanical ventilation, heart massage.
special instructions
Do not mix in the same syringe with others. medicines. Urinary excretion of one of the biotransformation products can cause red staining of urine ( clinical significance does not have and disappears after cancellation).
Storage conditions of the drug Baralgin ® M
In a place protected from light, at a temperature of 8-25 ° C.Keep out of the reach of children.
Shelf life of the drug Baralgin ® M
4 years.Do not use after the expiry date stated on the packaging.
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| N23 Renal colic unspecified | Pain syndrome in renal colic |
| Pain syndrome with spasms of smooth muscles | |
| Pain syndrome with spasms of smooth muscles (renal and biliary colic, intestinal spasm, dysmenorrhea) | |
| Pain syndrome with spasms of smooth muscles internal organs | |
| Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea) | |
| Colic renal | |
| Ureteric colic | |
| Renal colic | |
| Renal colic with urolithiasis | |
| nephrolithiasis | |
| Spasm of smooth muscles in diseases of the urinary system | |
| Spasm of the urinary tract | |
| Spasm of the ureter | |
| Spasm of the ureters | |
| Spasms of the urinary tract | |
| Spasms of the urinary tract | |
| R10.4 Other and unspecified abdominal pain | Abdominal pain syndrome |
| Abdominal pain | |
| baby colic | |
| gastrointestinal spasm | |
| intestinal colic | |
| Colic intestinal | |
| Colic in young children | |
| Colic in newborns | |
| Feeling of fullness in the stomach | |
| Cutting in the stomach | |
| Spasm of smooth muscles in diseases of the gastrointestinal tract | |
| Spasm of the bile ducts | |
| Spasm of the biliary tract | |
| Intestinal spasm | |
| Spasm of the digestive tract | |
| Spasms of smooth muscles of the gastrointestinal tract | |
| Stomach cramps | |
| Spasms of the gastrointestinal tract | |
| Spastic conditions of the gastrointestinal tract | |
| Tenesmus of the intestine | |
| Feeling of stomach fullness |
Baralgin is medicinal product from the group of NSAIDs, non-selective action (blocks both COX-1 and COX-2), a derivative of pyrazolones. Main active substance this tool- metamizole sodium. There are several forms of release of Baralgin:
- Tablets Baralgin M - 500 mg of the active substance each
- Solution for injection Baralgin M - 500 mg of the active substance in each ml, in a 5 ml ampoule (2.5 g in each ampoule)
- Solution for injection Baralgin - in a 5 ml ampoule contains 2.5 g of metamizole sodium, 0.01 g of pitofenone hydrochloride and 0.0001 g of fenpiverinium bromide
- Baralgin tablets - 0.5 g of metamizole sodium, 0.005 g of pitofenone hydrochloride and 0.0001 g of fenpiverinium bromide in each tablet
Indications for use Baralgin
Baralgin is indicated for almost any lesion of the spine and its structures, which are accompanied by pain:
- Injuries spinal column(fractures, bruises, dislocations, etc.)
- Spinal tumors (both malignant and benign)
- Postoperative period due to spinal surgery
Contraindications
There are a number of diseases and conditions in a patient in which Baralgin is contraindicated:
- Allergy to the drug and its components
- porfiria
- Feeding the baby breast milk
- Pregnancy up to 12 weeks and after 28 weeks of gestation
- Deficiency of the enzyme glucose-6-phosphate dehydrogenase
- Angle-closure glaucoma
- Bronchial asthma
- Renal and liver failure
- Frequent fainting
- Severe cardiac arrhythmias
Operating principle
The main active ingredient of Baralgin is metamizole sodium. It blocks cyclooxygenase 1 and 2 fractions, causing a pronounced analgesic effect, and also reduces local elevated temperature fabrics and inflammatory processes in them. These effects are achieved by stopping the production of prostaglandins (inflammatory mediators) and increasing the threshold pain sensitivity in the brain.
Fenpiverinium is an anticholinergic drug with ganglioblocking action. Those. given substance due to the blockade of nerve impulses through certain receptors, it helps to reduce the tone of smooth muscles located in the walls of blood vessels, which helps to improve blood flow.
Pitophenone is an antispasmodic with an action similar to papaverine. It also affects the tone of smooth muscles, reducing it and normalizing blood flow, and also slightly reduces the tone of the striated muscles of the back.
Thus, after taking Baralgin, the patient feels a decrease in pain, restoration of spinal mobility, acceleration of tissue repair and recovery of the patient.
Mode of application
Baralgin in the form of tablets
Tablets should be taken orally with enough liquids, preferably immediately after meals (reduces the likelihood of side effects and improves absorption of substances). The multiplicity of reception is 1-2 tablets 3-4 times a day. The interval between doses should be at least 5 hours. The maximum daily dosage is 3 g (6 tablets). The course of treatment is from 5 days to 2 weeks. If necessary, it can be extended under the supervision of the attending physician.
Baralgin in the form of a solution for injections
It should be administered intramuscularly or intravenously. A single dosage is from 2 to 5 ml. The maximum daily dosage is 10 ml. Children weighing 5-8 kg - 0.1-0.2 ml in the gluteal or femoral muscle. With a body weight of 9 to 15 kg - 0.2-0.5 ml into the gluteal muscle or into a vein. Children weighing from 16 to 23 kg - 0.3-0.8 ml of Baralgin. In the case when the child weighs 24-30 kg - 0.4-1 ml of the drug. With a weight of 31-45 kg - from 0.5 to 1.5 ml. And at 46-53 kg - 0.8-1.8 ml. With a patient weighing more than 53 kg or older than 15 years, adult dosages of Baralgin are prescribed. The course of treatment with injectable forms of the drug is a maximum of 5 days, after which, if necessary, the patient is transferred to tablet forms.
Side effects
Baralgin with individual intolerance can cause a number of side effects. The main ones are:
- Itchy skin rash
- Anaphylactic shock
- Quincke's edema
- Discomfort or pain in the abdomen
- Constipation
- Decrease in blood pressure figures
- Increased heart rate
- Dizziness
- Red urine
- Dry mouth
- Reducing one-time and daily amount urine
- Decrease in red blood cells, platelets and white blood cells
If such symptoms occur, the drug should be discontinued and, if necessary, symptomatic agents should be prescribed.
When exceeding daily dosage Baralgin, some symptoms may develop:
- Renal or liver failure
- Respiratory dysfunction
- Nausea and vomiting
- Headache
For the treatment of such conditions, it is necessary to immediately stop taking the drug, induce vomiting, wash the stomach and take sorbents. If necessary, symptomatic agents.
special instructions
During pregnancy for a period of 1 to 12 weeks and from 28 weeks before delivery, Baralgin is contraindicated. In the period from 13 to 27 weeks, the drug is allowed only under the strict supervision of a doctor and with emergency. During lactation, if it is necessary to take Baralgin, breastfeeding is possible 2 days after the last dose of this medication.
Baralgin is allowed for children with strict observance drug dosages. The tablet form is possible for reception only after 6 years.
Alcoholic drinks do not affect the effect of the drug.
Baralgin's analogs
Analgin, Spazmalgon, Spazmalgin, Trigan, etc.
The medicine "Baralgin" (injections), the price of which varies within 150 rubles, is included in the category of non-narcotic medicines, is a derivative of pyrazolone. The drug has a slight anti-inflammatory effect, has an antipyretic, analgesic effect. Active substances- metamizole, pitofenone hydrochloride and fenpivirinium bromide. The combination of components provides antispasmodic and analgesic effects. Substances have the ability to mutually reinforce each other's activity.
The drug "Baralgin" (injections). Instruction. Indications
The remedy is prescribed for pain syndrome (moderate or mildly expressed) on the basis of spasms in the smooth muscles of the internal organs. In particular, the indications include hepatic, biliary, renal, dyskinesia in the biliary tract, chronic colitis. The medication "Baralgin" (injections) is prescribed, the instructions for use confirm this, with spasms in bladder and ureter, sciatica, neuralgia, algomenorrhea, pathologies in the pelvic organs. Recommended medicine for myalgia, arthralgia. The drug is prescribed as an auxiliary to eliminate pain after diagnostic and surgical procedures.
Contraindications
The agent is not recommended for intolerance to the components, renal or hepatic insufficiency of a pronounced type, depressed bone marrow hematopoiesis, angina pectoris severe course, tachyarrhythmias. The drug is not prescribed for intestinal obstruction, prostate hyperplasia, pregnancy. Contraindications include megacolon, angle-closure glaucoma, childhood(up to three months) and weighing less than five kilograms. The remedy "Baralgin" (injections) is not prescribed, the instructions for use warn of this, during lactation, collapse. Caution is exercised in the presence of anamnestic data on hepatic or kidney failure, "aspirin triad", intolerance to other non-narcotic PVM.
Side effect
On the basis of therapy, the occurrence of allergic skin manifestations. In particular, urticaria is observed (on the mucous membranes of the nasopharynx and conjunctiva, including), bronchospastic syndrome, erythema exudative type malignant course. The drug can cause a change in interstitial nephritis, oliguria, decreased sweating, disorders of the kidneys, proteinuria, tachycardia, Means "Baralgin" (injections), instructions for use warns about this, can cause difficulty urinating, difficulty swallowing, paresis of accommodation, anaphylactic shock. In the injection site, infiltrates are likely to occur. In rare cases, stomatitis, proctitis, vaginitis can be observed.
Means "Baralgin" (injections). Instructions for use
The introduction is carried out in a vein for a minute, 1 ml. total dose- 2 ml per day. In some cases, repeated injection after six to eight hours is allowed. Intramuscularly injected 2-5 ml twice or thrice during the day. Duration of use of the drug - no more than five days. Dosages for children are determined by a specialist.
Baralgin is a non-narcotic analgesic. The half-life of the drug is 14-15 minutes. current active ingredient injections - sodium metamizole, in 1 ml of the drug - 500 mg. The ampoule holds 5 ml. Another component is water for injection. The action of the anesthetic is enhanced by the components - this is fenpiverinium bromide and pitofenone hydrochloride. The symbiosis of the constituents makes it possible for a short time achieve maximum number painkiller in the blood.
The pharmacological action of Baralgin injections lasts a long time. The intramuscular injection of Baralgin, thanks to its components, removes spasmodic contractions of smooth muscles and gives an analgesic effect on pain.
How to use correctly
The injections are prescribed by a doctor. They are made with:
Intramuscular administration baralgin is not painless. First, the contents of the ampoule are heated to body temperature (in order to reduce pain during injection).
Intravenous administration of the drug is allowed in exceptional situations, with the supervision of a health worker. If it enters the blood soon, the action of the drug can cause cardiac arrest.
The rate of entry of the drug into the vein should be up to one milliliter per minute, the procedure is performed when the person is lying down. Analyzed breathing, heart rate, arterial pressure. With the introduction of Baralgin in an amount of more than 2 ml, blood pressure may drop rapidly.
The instruction provides for the use of the drug in injections without medical consultation to relieve pain of identified origin. To reduce the temperature, use only according to medical recommendation. This is done when other antipyretic drugs are ineffective.
For problems with bladder the remedy is used if it is known for certain that there is no internal bleeding(components of the drug can cause an increase in blood loss due to the expansion of the vascular lumen). Intramuscular administration will improve the condition of someone who is experiencing pain from the movement of a stone formation through the ureter. It is allowed to use Baralgin in the absence of a medical recommendation for a maximum of three days. If after this period the pain has not gone away, then it is necessary to contact the doctor as soon as possible to determine the diagnosis and prescribe the correct treatment course.
Doses, frequency of use:
- Intramuscularly injected 5 ml twice a day;
- Intravenously, the drug is used for renal, biliary colic in an amount of a maximum of 3 ml at a time, you need to dilute Baralgin when injected into a vein with an isotonic solution of sodium chloride.
Side effects
Due to improper use of the drug, systemic inhibition of hematopoietic function may occur. A week after continuous use of the drug, a slight anemia appears.
With the introduction of more than the prescribed daily dosage, the renal system suffers, as a result of which urine is not excreted, protein appears in it. Severe cases- development of toxic nephritis. An abscess may occur with intramuscular injection.
Also side effects are:
- Phlebitis, soreness in the injection area;
- Burning sensation, itching;
- Leukopenia (sometimes - thrombocytopenia, agranulocytosis);
- Quincke's edema;
- The appearance of a rash;
- Interruptions in the activity of the kidneys - anuria, urine staining in a reddish hue, proteinuria, oliguria, in some cases - acute interstitial nephritis;
- The presence of bronchospasm;
- Anaphylactoid signs;
- Arrhythmia;
- A rapid decrease in blood pressure;
- Sometimes there are syndromes: Lyell or Stevens-Johnson.
The drug should not be used by pregnant women at any time
With the threat to life existing for the mother, if only baralgin helps, a serious question arises about abortion. Baralgin tablets can be taken by children over 5 years of age. Before this age, you can use the medicine in the form of intravenous or intramuscular injections. In children from the age of three months, with a weight of more than 5 kg, the drug is administered exclusively intramuscularly: 50-100 mg per 10 kilograms of weight (0.1-0.2 ml of 50% solution). single dose allowed a maximum of three times a day.
At breastfeeding will have to not resort to Baralgin. The components of the product enter the milk and lead to lesions of the internal organs of the child.
Also contraindications are:
- Intestinal obstruction, its invagination;
- Imperfection of the kidneys, liver;
- Angle-closure glaucoma;
- Anemia, ischemia in the uncompensated stage;
- Bronchial asthma or other diseases that can lead to bronchospasm;
- Particularly noticeable susceptibility to pyrazolones, metamizole sodium;
- There is a risk of hemolysis in the presence of congenital deficiencies of glucose-6-phosphate dehydrogenase;
- Allergies to analgesics - edema, rhinitis, urticaria;
- Age category up to three months, weight up to 5 kg;
- Instability in the work of the bone marrow;
- The likelihood of attacks of porphyria is when using Baralgin by people who have acute intermittent hepatic porphyria;
- Reduced blood pressure, hemodynamic disturbances.
Special instructions
At simultaneous reception cytostatic agents should be treated with Baralgin only under medical supervision. If you need to be treated for a long time, then from time to time the composition of the blood is monitored. When agranulocytosis is caused by the presence of metamizole in the body and its duration is 7 days, it is life-threatening. The occurrence of this condition is not related to the dosage.
Refuse to use Baralgin should be when the temperature rises with chills, pain in oral cavity, the appearance of erosion on the mucous membranes. Explicit neutropenia also provides for the abolition of the drug. Anaphylaxis is often present in patients with allergic reactions, bronchial asthma in the past. Patients with rashes, rhinosinusitis, intolerances to dyes and alcohol are also at risk. You can not use Baralgin when there are significant pain V abdominal cavity in the absence of an accurate diagnosis.
Intramuscularly, Baralgin is injected with long needles.
Do not do intravenous injections patients under 1 year of age.
Transport management during treatment with Baralgin is possible, but care should be taken at high dosages.
Needed in case of overdose symptomatic therapy. There is an option to use hemodialysis, forced diuresis. Diazepam is given intravenously if there are convulsions.
Connection with other drugs
Baralgin increases the sedative effect of alcohol. Reception of others non-narcotic analgesics together with Baralgin will cause an increase in toxic effects. When taken with cyclosporine, plasma levels need to be monitored.