"Mezim forte 10000" - medicine, part of the group enzyme preparations, prescribed for secretory insufficiency gastrointestinal tract.
What are the composition and release form of the medication Mezim forte 10000?
The active ingredients of the pharmaceutical drug Mezim forte 10000 are represented by pancreatin in an amount equal to 137.5 mg. Auxiliary components of the drug: hypromellose, crospovidone, titanium dioxide, microcrystalline cellulose, triethyl citrate, in addition, polysorbate 80, carmellose sodium, magnesium stearate, lactose monohydrate, silicon dioxide, talc, macrogol 6000, sodium hydroxide, azorubic varnish, simethicone emulsion.
The drug Mezim forte 10000 is available in the form of a pink, round tablet with an enteric coating. Supplied in blisters of 10 pieces. Sold without a prescription.
What is the effect of Mezim forte 10000?
The drug Mezim forte 10000 is intended to replenish the enzymatic deficiency of the secretory apparatus of the gastrointestinal tract. Active substance medicine - pancreatin, is a fine powder created from pork pancreas that has undergone careful processing.
IN active substance The drug contains pancreatic enzymes: amylase, lipase, and protease. These substances can significantly improve the flow of digestive processes, normalizing the processes of fermentation and adsorption of nutrients.
The drug shell dissolves in the lumen small intestine, because it is acid-resistant, able to withstand aggressive factors of gastric juice. Dissolution of the drug shell is possible only in a neutral or slightly alkaline environment of the small intestine.
Complete dissolution of the dosage form occurs no earlier than 45 minutes after oral administration. The pathways of metabolization of exogenous enzymes are similar to their endogenous counterparts synthesized by the pancreas.
What are the indications for use of Mezim forte 10000?
The instructions for use allow taking the enzymatic pharmaceutical product Mezim forte 10000 in the following cases:
Insufficiency of the enzymatic function of the pancreas, with or;
Chronic dystrophic diseases gastrointestinal tract or gallbladder;
Condition after gastrectomy;
Condition after the procedure;
Consequences of severe infectious diseases;
Irritable bowel syndrome;
Exacerbation chronic diseases intestines;
Acute infectious diseases Gastrointestinal tract;
Galactose intolerance.
Also, less than 3 years of age.
What are the uses and dosages of Mezim forte 10000 tablets?
The most appropriate dosage should be selected taking into account the residual enzymatic activity of the pancreas. The average dose recommended for most patients is 2–4 tablets of Mezim forte 10,000 per meal.
The drug should be taken in two parts. Before meals, you must take one third of the recommended amount of medicine. The rest of the pharmaceutical product should be taken after the meal.
The tablet must not be chewed or crushed. Only if the integrity of the shell is maintained will the enzymes contained in pancreatin be delivered to the small intestine. Otherwise, all enzyme complexes will be inactivated.
The duration of use of the enzyme preparation is very variable and can range from several days, in case of errors in the diet, to lifelong use in case of insufficiency of the enzymatic function of the pancreas.
Why is Mezim forte 10000 dangerous, what are its side effects?
Since pancreatin is characterized natural origin, treatment is rarely accompanied by side effects, the most common of which are allergic reactions, as skin rashes, redness and so on.
However, taking the enzymatic drug Mezim forte 10000, which we continue to talk about on this page www.site, may be accompanied by the following negative consequences: discomfort or slight pain in the abdomen, possible or, in addition, nausea, vomiting.
How to replace Mezim Forte 10000, what analogues are suitable?
Penzital, Gastenorm forte 10000, Pancreotin, Panzim forte, Pancrelipase, Pancreatina tablets, Pancreatin forte, Pankrenorm, Pangrol 25000, Creon 40000, Panzinorm 10000, Creon 25000, Micrazim, Mezim 20000, Pancreazim, Biozym, Ermital, , Pangrol10000, Panzinorm forte 20000, Pancreatin, Panzinorm 10000, Uni-Festal, PanziCam, Pancreatin-concentrate, Enzistal-P, Festal N, as well as Pancreatin-LekT.
Conclusion
You can use the drug Mezim forte 10000 for errors in nutrition independently, without turning to specialists. Enzyme deficiency pancreas involves periodic monitoring of the effectiveness of therapy and careful selection of dosage. In this case, it is recommended to consult a doctor.
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Tatyana, www.site
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Active substance: 1 enteric tablet contains powder from the pancreas (pig) 125 mg, which has a minimum political activity of 10,000 EF units, a minimum amylolytic activity of 7500 EF units, a minimum proteolytic activity of 375 EF units. ;
Excipients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate, hypromellose, methacrylate copolymer (type A), triethyl citrate, titanium dioxide (E 171), talc, simethicone, polyethylene glycol, sodium carmellose, polysorbate, azorubine (E 122) , sodium hydroxide.
Dosage form"type="checkbox">
Dosage form
Enteric tablets.
Pink coated tablets film-coated, with almost plane-parallel surfaces and a beveled edge.
Pharmacological group"type="checkbox">
Pharmacological group
Multienzyme drugs. ATS code A09A A02.
Pancreatin- a pancreatic enzyme that takes part in the digestion of proteins, fats and carbohydrates in digestive tract. The decisive factor is the enzymatic activity of lipase, as well as the trypsin content, while amylolytic activity is important only in the treatment of cystic fibrosis, since even with a significant decrease in the secretory activity of the pancreas, amylase has sufficient activity. The coating covering the tablets is insoluble under the influence of gastric juice and protects enzymes from their inactivation gastric juice. Only under the influence of neutral or slightly alkaline environment small intestine, the membrane dissolves and enzymes are released.
Indications
- Diseases accompanied by disturbances in the digestion of food due to insufficient excretion digestive enzymes pancreas, such as chronic pancreatitis, cystic fibrosis.
- Conditions after simultaneous resection of the stomach and small intestine, functional acceleration of food passage through the intestines, intestinal disorders, simultaneous use difficult to digest vegetable, fatty and unusual foods.
- Intestinal bloating and preparation for x-ray or ultrasound diagnostic studies.
Contraindications
Increased sensitivity to porcine pancreatin, azorubine varnish or other excipients drug. Acute pancreatitis or chronic pancreatitis in the acute stage (but occasional use is possible in the phase of fading exacerbation when expanding the diet in the presence of impaired pancreatic function). The drug should not be used in patients with obstructive intestinal obstruction.
Proper safety precautions for use
Intestinal obstruction- this is a known complication in patients with cystic fibrosis, therefore, if symptoms resemble this condition, it is necessary to remember about possible intestinal strictures. The drug contains active enzymes that can damage the mucous membrane oral cavity, up to the formation of ulcers, so the tablets must be swallowed whole without chewing. The drug should not be used in patients with rare hereditary forms galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.
Use during pregnancy or breastfeeding
During pregnancy and breastfeeding, take the drug as prescribed by a doctor if the expected benefit to the mother outweighs the potential risk to the fetus/child.
The ability to influence the reaction rate when driving vehicles or other mechanisms
There are no reservations.
Children
Use for children aged 3 years and older.
Directions for use and doses
The dose of Mezim â forte 10000 depends on the deficiency of pancreatic enzymes in duodenum and is installed individually. If there are no other recommendations and in cases of consumption of difficult-to-digest plant food, fatty or unusual foods, take 1-2 tablets. In other above-mentioned cases, when digestive disorders occur, the recommended dose is 2-4 tablets. If necessary, the dose can be increased. Increasing the dose to reduce symptoms of the disease, such as steatorrhea or abdominal pain, should only be done under the supervision of a physician. The daily dose of lipase should not exceed 15,000-20,000 IU E.F. per 1 kg of body weight.
Take the tablets with meals, swallow them whole with plenty of liquid, such as a glass of water.
The duration of treatment depends on the course of the disease and is determined by the doctor individually.
The question of the dosage of the drug and the duration of treatment for children is decided by the doctor.
Mezim ® forte 10000 should be prescribed in the daily dose required to normalize stool, but not more than 1500 IU of lipase per 1 kg of body weight of a child under 12 years of age. Children over 12 years old daily dose enzymes should not exceed 15,000-20,000 IU E.F. lipase per 1 kg of body weight.
Overdose
Strengthening possible side effects. During administration, it is extremely high doses Hyperuricemia and hyperuricosuria have been observed with other pancreatic powder preparations. Treatment is symptomatic.
Side effects
To assess the frequency of side effects, the following gradation is used: very often ≥ 1/10; often: ≥ 1/100 and<1/10; иногда: ≥ 1/1000 и <1/100; редко ≥ 1/10000 и <1/1000; очень редко <1/10000, частота неизвестна (оценка не может быть проведена по имеющимся данным).
From the cardiovascular system. Frequency unknown: tachycardia.
From the immune system. Very rarely, immediate allergic reactions (skin rash, sneezing, lacrimation, bronchospasm). Frequency unknown: Azorubic varnish (E 122) may cause allergic reactions.
From the digestive tract. Very rarely, in patients with cystic fibrosis, when using high doses of pancreatin, narrowing may form in the ileocecal region and in the ascending colon; allergic reactions from the digestive tract (diarrhea, abdominal pain, nausea, change in stool character).
The main organ in the human digestive system is the stomach - the main process of food digestion takes place here, in which many enzymes take part. Their deficiency provokes unpleasant sensations: pain, a feeling of heaviness, heartburn. You can get rid of them by buying Mezim at the pharmacy.
1 Registration number and ATX
In the anatomical-therapeutic-chemical classification it has code A09AA02 - multienzyme preparations. Registration number - No. 14681/01.
On the shelves of pharmacies you can find Mezim, the name of which has the word “forte” added to it. It means that the tablets are in an enteric coating, which protects the enzymes they contain from loss or reduction in activity.
2 Indications for use
You can take Mezim:
- if you have to do an ultrasound of the abdominal organs (usually the drug is taken the night before);
- if you have chronic diseases of the gastrointestinal tract, liver and gallbladder;
- there are gastrointestinal disorders;
- if you have insufficiency of the exocrine function of the pancreas (chronic pancreatitis, cystic fibrosis, etc.);
- when it is necessary to restore the gastrointestinal tract after radiation therapy or removal of an organ;
- if it is necessary to prepare for an x-ray examination;;
- after overeating or regular poor nutrition.
3 Pharmacological action
Mezim is an enzyme drug that helps the gastrointestinal tract function. The main medicinal substance in it is pancreatin, which contains lipases, amylases, proteases, etc.
Pharmacodynamics: pancreatic enzymes promote the breakdown of essential nutrients, which are subsequently more easily absorbed in the small intestine. Trypsin in the composition relieves pain. The effect is most felt after 30-45 minutes.
Pharmacokinetics: the acid-resistant shell dissolves only in a neutral or slightly alkaline environment, therefore, despite the influence of stomach acid, enzymes are preserved and activated in the intestine.
If Mezim tablets do not have a protective film, then they can be used as an anesthetic for chronic pancreatitis.
4 Composition and release form
Pink round tablets.
1 pill contains the active ingredient - 137.5 mg of pancreatin. There are excipients: lactose, cellulose, silicon dioxide, etc.
Important! Pancreatin is not a monosubstance. It consists of lipase, protease and amylase. The first is involved in the breakdown of lipids, the second - proteins, the third - carbohydrates.
5 How to take?
Dosage
You can use the instructions without a doctor's prescription. According to it, adults can take from 2 to 4 tablets at a time. In children, the dose is lower - no more than 500-20,000 Ph units. Eur. lipase per kilogram of body weight.
Before or after meals?
The tablets should be taken as follows:
- 1/3 or 1/2 of a single dose as soon as you start eating;
- the rest - in the middle of the meal.
It is recommended that you swallow the tablet while sitting or standing to prevent the pill from sticking to the esophagus, where premature release of digestive enzymes may occur. After taking it, do not lie down for at least 5 minutes. In addition, by sticking to the esophagus, the drug can damage its mucous membrane.
Duration of use
The duration of treatment depends on the prescription of the gastroenterologist or therapist. This could be several days, months or years.
If taking Mezim is caused by digestive disorders as a result of overeating or eating unhealthy food, then you cannot save yourself with the drug every time for a long time. Firstly, this will cause addiction to the drug, and secondly, the secretion of the pancreas decreases and it stops producing its enzymes.
For the treatment of chronic gastrointestinal diseases, lifelong use of the drug is possible. For example, with flatulence, gallbladder diseases. You will have to use Mezim after some surgical operations; in case of obstruction of the bile duct, its perforation; inflammation or injury to the pancreas. Then Mezim is prescribed for manifestations of dyspepsia.
6 Features of application
Pregnancy and lactation
During pregnancy, a peculiar restructuring occurs in a woman’s body, often accompanied by unpleasant sensations, including from the gastrointestinal tract. The enlarging uterus puts pressure on the internal organs and interferes with the normal processes of food digestion.
Pregnant women and women whose children are breastfed can take Mezim, but only with a doctor's prescription. If there is a deficiency of enzymes or their improper absorption, the drug is prescribed, since the lack of nutrients leads to improper development of the child.
Childhood
Due to their age, children, especially young ones, cannot independently determine their food culture. In addition, a child, while learning about the world around him, puts foreign objects into his mouth, which are not always clean. Dirt also enters the body through unwashed hands. Children sometimes eat excessively fatty or fried foods. All this can provoke digestive disorders, accompanied by:
- nausea and vomiting;
- diarrhea or constipation;
- flatulence, seething, pain;
- loss of appetite and weight loss;
- motor passivity.
To eliminate them, you can use Mezim. However, remember that use should not become regular as a panacea for any gastrointestinal disorders. If these pathologies are observed frequently, take your child to the pediatrician.
If children are under 12 years old, they are entitled to up to 1,500 lipase IU per 1 kilogram of weight, and older ones - no more than 20,000.
Important! Do not crush or mix the tablet in liquids. This will disrupt the integrity of the acid-resistant film, and the enzymes will not reach the intestines.
Elderly age
As a result of the aging of the human body, the capabilities of all organs, in particular the digestive tract, become limited. Involution of the gastrointestinal tract occurs slowly and is associated primarily with a decrease in the functional activity of the pancreas, which plays a major role in the breakdown of food.
Age-related destruction of the gland begins at the age of 40, but under unfavorable conditions it can occur earlier. Elderly and elderly people are often diagnosed with chronic pancreatitis with manifestations in the form of flatulence, pain, abnormal bowel movements, etc. To improve the condition, doctors prescribe digestive enzyme preparations.
The drug has shown good results in the treatment of chronic pancreatitis.
- Abdominal bloating decreases or disappears.
- Pain syndrome (abdominal pain) is relieved.
- The drug is well tolerated.
- With continuous use, a complete correction of maltigestion and malabsorption occurs.
Mezim should be taken 1-2 tablets 3 times a day with meals. 2 tablets are immediately prescribed for severe pain to speed up its relief.
For liver dysfunction
Mezim is not a specific medicine for liver cirrhosis, but is used as part of a combination treatment.
This serious disease is accompanied by dysbiosis and deficiency of pancreatic enzymes. Flatulence, pain, and a feeling of inoperative gastrointestinal tract are recommended to be relieved with the help of enzyme preparations. Festal is sometimes taken, but it contains bile acids that accumulate in the body. Mezim does not have this feature and is no less effective.
For renal dysfunction
Kidney diseases are sometimes accompanied by gastrointestinal reactions such as nausea and vomiting. However, as part of complex therapy, Mezim is not used to relieve these symptoms, since they have a different etiology that has nothing to do with a violation of the enzymatic ability of the pancreas.
7 Side effects
For some diseases, Mezim is taken for a long time, and no side effects have been recorded. Theoretically, it is possible to develop allergic reactions to the components of the drug, rarely - diarrhea, constipation or discomfort in the abdomen.
In some patients with cystic fibrosis, when taking large doses of the drug for a long time, hyperuricemia and narrowing of intestinal sections (formation of strictures) may develop.
Effect on driving
Mezim does not affect the driver’s reaction speed and his perception or assessment of the situation, therefore, taking this drug to people whose profession is associated with driving vehicles or with complex mechanisms does not pose a danger.
8 Contraindications
Mezim in any dosage of pancreatin is contraindicated if you have:
- hypersensitivity;
- hereditary hypolactasia;
- there is not enough lactase or there is glucose-galactose malabsorption syndrome;
- acute pancreatitis;
- exacerbation of chronic pancreatitis;
Important! The drug should not be given to children under 3 years of age.
9 Interaction with other drugs
If you take an iron supplement, then in tandem with Mezim they will not be fully absorbed, which will cause anemia. Temporarily exclude Mezim from your therapy or the doctor will select another medicine.
When taking pancreatin, folic acid is poorly absorbed and the effect of glucose-lowering drugs worsens.
Antacids reduce the effectiveness of Mezim.
10 Compatibility with alcohol
Mezim can improve digestion not only during a hangover, but also during a feast. With moderate alcohol consumption, the drug accelerates the breakdown of ethanol, thereby reducing its harm to the liver, kidneys and brain. The drug begins to act within half an hour after administration, at the same time the person who has consumed alcohol begins to sober up.
With constant use of Mezim, drinking alcohol reduces the effectiveness of the drug. The harm from such a tandem is considered minimal, compatibility is relative.
11 Overdose
There is no need to interfere with this process. This is how the body tries to get rid of excess drug on its own. If severe nausea is observed, but there is no vomiting, it can be induced artificially, then give the victim plenty of fluids, a diuretic or laxative.
Sometimes an overdose occurs due to long-term use of the drug, for example, in the treatment of chronic pancreatitis, which can lead to hyperuricemia or hyperuricosuria. In such cases, Mezim is canceled.
In children, an overdose may cause constipation.
12 Conditions for dispensing Mezima 10000 from pharmacies
No prescription required.
How much does the drug cost?
The price depends on the number of tablets in the box: from 66 rubles for 20 pieces, up to 300 rubles for 80 pieces.
13 Storage conditions for Mezim 10000
The medicine should be stored at a temperature less than +25°C where children cannot reach.
Best before date
The drug should not be stored or used for longer than 3 years from the date of release. The manufacturing date can be found on the packaging.
14 Analogues of Mezim 10000
On the shelves of pharmacies you can find a wide range of drugs for the treatment of gastrointestinal diseases. They differ from each other in the dosage of the active substance.
If Mezim is not available, you can choose:
- Pancreatin;
- Hermital;
- Penzital;
- Micrasim;
- Panzinorm;
- Gastenorm;
- Creon 10000.
All these medicines differ not only in the amount of active substance they contain, but also in price.
What is the difference between regular Mezim:
Mezim Forte 1000
Pancreatitis and Mezim
Mezim forte
From heaviness in the stomach
Thank you
Registration number: P N014681/01 dated 03.24.09
Trade patent name: Mezim® forte 10000
International nonproprietary name
or group name: Pancreatin
Dosage form: enteric-coated tablets
Composition per tablet
Core
Active substance: Pancreatin powder –137.5 mg
with minimal enzymatic activity:
lipase 10000 units Ph. Eur.
amylase 7500 units Ph. Eur.
protease 375 units Ph. Eur.
Excipients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate; shell: hypromellose (~5 mPa s), methacrylic acid and ethyl acrylate copolymer (1:1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E 171), talc, simethicone emulsion 30% (dry weight), macrogol 6000 , carmellose sodium (~ 30 mPa s), polysorbate 80, azorubic varnish (E 122), sodium hydroxide.
Description: pink round tablets, enteric-coated, with biconvex surfaces, chamfered, brown inclusions are possible at the break.
Pharmacotherapeutic group: Digestive enzyme agent
ATX code: A09AA02.
Pharmacological properties
Pharmacodynamics. An enzyme preparation that improves digestion.
Pancreatin is a powder from pork pancreas, which, along with the exocrine pancreatic enzymes - lipase, amylase, protease, trypsin and chymotrypsin, also contains other enzymes.
Pancreatic enzymes included in the drug facilitate the breakdown of proteins, fats and carbohydrates, which leads to their more complete absorption in the small intestine. Trypsin suppresses stimulated pancreatic secretion, producing an analgesic effect. The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.
Pharmacokinetics. Mezim ® forte 10000 tablets are coated with an acid-resistant coating that does not dissolve under the action of stomach hydrochloric acid and thereby protects the enzymes contained in the drug from inactivation. Dissolution of the shell and release of enzymes occurs at a pH value close to neutral or slightly alkaline.
Indications for use
- replacement therapy for exocrine pancreatic insufficiency (including chronic pancreatitis, cystic fibrosis);- chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gall bladder;
- conditions after resection or irradiation of the gastrointestinal tract, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy);
- gastrointestinal disorder of a functional nature (with intestinal infectious diseases, irritable bowel syndrome, etc.);
- to improve food digestion in patients with normal gastrointestinal function in case of errors in nutrition;
- preparation for x-ray and ultrasound examinations of the abdominal organs.
Contraindications
- acute pancreatitis;
- exacerbation of chronic pancreatitis;
- hypersensitivity to pancreatin or other components of the drug;
- hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
- children under 3 years of age (indivisible dosage form).
Use during pregnancy and lactation
Due to the lack of sufficient data on the use of pancreatic enzymes in humans during pregnancy and lactation, the use of Mezim forte 10000 is possible only if the expected benefit to the mother outweighs the possible risk to the fetus or child.Directions for use and doses
The dose of Mezim ® forte 10000 is set individually depending on the severity of the disease and the composition of the food.Unless otherwise indicated, the average single dose for adults is 2-4 tablets of Mezim ® forte 10000 per meal. It is recommended to take half or a third of a single dose at the beginning of a meal, and the rest during it. The drug is taken orally, without chewing and with a sufficient amount of liquid.
It is possible to increase the dose, which should only be carried out under the supervision of a physician, focusing on the weakening of symptoms (for example, steatorrhea, abdominal pain).
The maximum daily dose is 15,000-20,000 Ph units. Eur. lipase/kg body weight.
For children, the dosage regimen is determined by the doctor depending on the severity of the disease and the composition of the food at the rate of 500-1000 Ph units. Eur. lipase / kg of child’s body weight for each meal.
The duration of treatment can vary from several days (for indigestion, dietary errors) to several months and even years (if constant replacement therapy is necessary).
Side effect
No side effects or complications were detected even with long-term and regular use of Mezim® forte 10000 in patients with impaired pancreatic function.In some cases, after taking pancreatin, allergic reactions may develop, rarely - diarrhea or constipation, nausea, discomfort in the epigastric region. In isolated cases, in patients suffering from cystic fibrosis, with prolonged use of high doses of the drug, hyperuricosuria (increased levels of uric acid in the blood plasma) may develop, and strictures may form in the ileocecal region and ascending colon.
Overdose
There are no data on cases of overdose and intoxication with the drug.Possible: hyperuricosuria, hyperuricemia, in children - constipation.
Treatment: drug withdrawal, symptomatic therapy.
Interaction with other drugs
When taking medications containing pancreatin, the absorption of folic acid may be reduced. The effect of hypoglycemic drugs (acarbose, miglitol) may decrease when taken simultaneously with pancreatin.
With the simultaneous use of pancreatin with iron preparations, the absorption of the latter may be reduced. The simultaneous use of antacids containing calcium carbonate and/or magnesium hydroxide may lead to a decrease in the effectiveness of the drug.
special instructions
In case of acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of attenuation of exacerbation), during a restorative diet, it is advisable to prescribe Mezim forte 10000 against the background of existing or remaining insufficiency of pancreatic function.
Mezim ® forte 10000, taking into account the solid indivisible dosage form, is contraindicated in children under 3 years of age.
Instructions for use
Mezim forte 10000 tab p.o No. 20
Dosage forms
pills
Synonyms
Gastenorm forte
Gastenorm forte 10000
Creon 10000
Creon 25000
Creon 40000
Mezim 20000
Mezim forte
Micrasim
Pangrol 10000
Pangrol 25000
Panzinorm 10000
Panzinorm forte 20000
Panzinorm forte-N
Pancreazim
Pancreatin
Pancreatin forte
Pancreatin-LekT
Penzital
Enzistal-P
Hermital
Group
Enzyme agents that improve digestion processes
International nonproprietary name
Pancreatin
Compound
The active ingredient is pancreatin.
Manufacturers
Berlin-Chemie AG (Germany), Berlin-Chemie AG/Menarini Group (Germany)
pharmachologic effect
Replenishes pancreatic enzyme deficiency. Contains excretory pancreatic enzymes: lipase, alpha-amylase, trypsin, chymotrypsin, promotes the breakdown of proteins (to amino acids), fats (to glycerol and fatty acids) and starch (to dextrins and monosaccharides), normalizes digestive processes. The enzymes that make up pancreatin are released in the alkaline environment of the small intestine, because protected from the action of gastric juice by the membrane. Trypsin in the upper part of the small intestine inhibits stimulated pancreatic secretion, causing the analgesic effect of pancreatin.
Side effect
Symptoms of intestinal obstruction (formation of strictures in the ileocecal region and ascending colon) and immediate allergic reactions (with cystic fibrosis, especially in children).
Indications for use
Digestive insufficiency in violation of the exocrine function of the pancreas: cystic fibrosis, chronic pancreatitis, pancreatectomy, dyspepsia, Roemheld syndrome, flatulence; impaired digestion of food, intestinal infections, chronic diseases in the liver and biliary tract, intestinal degassing before diagnostic studies.
Contraindications
Hypersensitivity (including pork intolerance), acute pancreatitis, exacerbation of chronic pancreatitis.
Directions for use and dosage
Orally, before meals, without chewing, with plenty of liquid (alkaline if possible: water, fruit juices). The dose is set individually, depending on the severity of the digestive disorder. In the usual dose - 1-2 tablets, if necessary, with meals, another 1-4 tablets. It is not recommended to exceed the daily dose of enzymes, which is 15,000-20,000 IU lipase/kg, especially in patients with cystic fibrosis. The duration of treatment can vary from several days (if the digestive process is disrupted due to errors in the diet) to several months and even years (if constant replacement therapy is necessary).
Overdose
No data.
Interaction
Reduces iron absorption (especially with long-term use).
special instructions
With long-term use, iron supplements should be prescribed. It is not recommended to exceed the daily dose, especially for patients with cystic fibrosis.
Storage conditions
In a dry place, protected from light.