Potassium hydrogen phosphate, potassium dihydrogen phosphate, sodium chloride, water for injection.
Release form
Eye ointment white in an aluminum tube with a polyethylene tip in a cardboard box 2.5 g.
Transparent, colorless eye drops in a polymer bottle with a 5 ml dropper in a cardboard box.
pharmachologic effect
Antibacterial, glucocorticoid, antiallergic, anti-inflammatory.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
The drug Dex-Gentamicin contains two highly compatible active components in the optimal dosage of each of them.
Instructions for use (Method and dosage)
Dex-Gentamicin ophthalmic ointment in the form of a strip about 1 cm long is placed into the conjunctival cavity 2-3 times a day. At the same time, during the procedure it is necessary to avoid contact of the tube with the surface of the conjunctiva and skin. When prescribing the simultaneous use of several ophthalmic agents, instructions for eye ointment Dexa-Gentamicin indicates the need to maintain a time interval between their use of at least 15 minutes.
Dex-Gentamicin eye drops are instilled directly into conjunctival sac in a dosage of 1-2 drops 5-6 times a day. Dexa-Gentamicin should not be used for more than 3 weeks.
Overdose
Overdose is unlikely when applied topically.
Interaction
At simultaneous administration with or others cholinergic drugs , the risk of increased intraocular pressure . Gentamicin when administered locally, cannot be combined with, cephalothin , sulfadiazine And cloxacillin , since this creates a risk of deposition of precipitates in the conjunctival cavity.
Terms of sale
According to a doctor's prescription.
Storage conditions
Storage temperature up to 25°C.
Best before date
3 years. Drops after opening the bottle should be used within 1.5 months.
Analogs
Level 4 ATX code matches:
Combined eye drops Betagenot (gentamicin + betamethasone ), (tobramycin + dexamethasone ), ( + dexamethasone + polymyxin B ), ( + dexamethasone ).
Reviews
This complex drug in the form of drops and ointments combines antibacterial and antiallergic effects. Judging by the reviews, it was prescribed for chronic conjunctivitis , blepharitis And blepharoconjunctivitis , in the case when allergic manifestations combined with a bacterial infection. After all, it is known that when allergic conjunctivitis sooner or later inflammation occurs, which has chronic nature. The drug is also effective in episcleritis , trauma to the conjunctiva and cornea, keratitis . All patients note high efficiency ointments and drops that have a pronounced anti-inflammatory effect.
- «… The child had purulent conjunctivitis, which was treated whole month sulfacyl and chloramphenicol drops. There was little result and the inflammation spread to the cornea. Dex-gentamicin ointment was prescribed. And we finally began to recover».
- «… Dex-Gentamicin ointment was prescribed to me for demodicosis of the eyelids, when it started purulent inflammation. Lubricated for 4-5 nights days - inflammation passed».
- «… Good ointment. It was used for ulcerative blepharitis: purulent crusts disappeared after 2 days, and ulcerations of the edges of the eyelids were treated for another five days».
- «… This ointment helped my husband quickly cure his stye. He is very pleased with the effectiveness of the ointment».
Many people were prescribed drops after ophthalmological operations, and they successfully prevented postoperative complications. All patients tolerated the drug well and adverse reactions not noted.
Pharmacodynamics
Gentamicin has a broad spectrum antimicrobial action. Active against most gram-negative bacteria: Escherichia coli, Klebsiella spp., indole-positive and indole-negative Proteus spp., Enterobacter spp., Providencia stuartii, Salmonella spp., Shigella spp., Acinetobacter spp., Pseudomonasaeruginosa; gram-positive cocci: Staphylococcus spp. (including those resistant to penicillins and other antibiotics), some strains of Streptococcus spp. Resistance of microorganisms to gentamicin develops slowly, but strains resistant to neomycin and kanamycin are also resistant to gentamicin.
Pharmacokinetics
It is practically not absorbed into the blood when instilled into the conjunctival sac. Penetrates the moisture of the anterior chamber of the eye, vitreous and corneal tissue, is not detected in the lens. The maximum level of gentamicin is observed within 30 minutes after administration, then the concentration decreases, mainly due to washout by tear fluid, remaining at the therapeutic level for a period of up to 6 hours.
Indications for use
Gentamicin is prescribed to treat infections caused by pathogens susceptible to it. The drug is prescribed for acute and chronic conjunctivitis, corneal ulcers, keratitis, keratoconjunctivitis, acute and chronic iritis, acute and chronic blepharitis, blepharoconjunctivitis, dacryocystitis and other infectious and inflammatory eye diseases, as well as for the prevention and treatment purulent complications after eye surgeries.
Directions for use and doses
Eye drops are instilled into the lower conjunctival sac of the affected eye 3-4 times a day, 1-2 drops. The duration of treatment depends on the type and severity of the disease and is determined by the doctor individually.
Recommendations for using tube droppers: before use medicine Remove the protective cap from the dropper tube and cut off the membrane of the body neck with scissors without damaging the threaded part. Turn the body of the dropper tube with the medicine neck down and gently press the body of the dropper tube, using it as a pipette. After using the dose recommended by the doctor or indicated in the instructions for use of the medicinal product, turn the body of the dropper tube over with the threaded part up and screw on the protective cap.
Side effect
Since the available modern clinical researches, which can be used to determine frequency unwanted effects, none, frequency of all of the following side effects classified as "frequency unknown."
From the side of the organ of vision: local sensitivity, blurred vision, eye irritation, burning sensation, itching in the eyes, redness of the conjunctiva, swelling.
From the skin and subcutaneous tissues: burning sensation, tingling, itching of the skin, dermatitis.
From the genitourinary system: nephrotoxicity, acute renal failure.
In rare cases, allergic reactions are possible.
If irritation, sensitivity or superinfection occurs, the drug should be discontinued and appropriate treatment prescribed.
Contraindications
Increased sensitivity to gentamicin or to any of the components of the drug, other aminoglycosides.
There is evidence that gentamicin can cause neuromuscular blockade and is therefore contraindicated in myasthenia gravis and concomitant diseases. The drug is contraindicated in case of perforation eardrum, with severe renal dysfunction, with diseases auditory nerve, vestibular apparatus, during pregnancy and breastfeeding (stop breast-feeding during treatment).
Overdose
When applied topically, it is absorbed into a small amount. Hemodialysis (more effective) and peritoneal dialysis will help remove the drug from the blood. Intravenous administration calcium salts have been used in neuromuscular blockade caused by gentamicin.
Precautionary measures
Long-term use should be avoided, which may lead to skin sensitization and the emergence of resistant microorganisms. Cross-sensitivity with other aminoglycoside antibiotics may develop. At severe infections local application gentamicin must be supplemented with systemic antibiotics. Caution is recommended when prescribing the drug concomitantly with systemic aminoglycosides. At long-term treatment Kidney and hearing function should be monitored. Eye drops should not be used by patients wearing contact lenses.
Use in children: There are no data on the effectiveness and safety of the drug in children.
Use during pregnancy and lactation. The use of the drug during pregnancy and lactation is contraindicated. During treatment with the drug, you must stop breastfeeding.
Impact on the ability to drive vehicles and other potentially dangerous mechanisms. Use caution when driving, operating industrial equipment, or performing other hazardous work. The drug may cause blurred vision. If you experience blurred vision, avoid hazardous activities.
Interaction with other drugs
At simultaneous use Gentamicin with potent diuretics such as ethacrynic acid and furosemide increases the risk of ototoxicity, while amphotericin B, cisplatin, cyclosporine and cephalosporins are potential enhancers of nephrotoxicity. The drug should not be prescribed simultaneously with other drugs that have ototoxic or nephrotoxic effects. Neuromuscular blockade and respiratory paralysis have been reported when aminoglycosides were administered to patients receiving muscle relaxants such as curare during anesthesia. Pharmaceutically incompatible with amphotericin, cephalosporins, erythromycin, heparin, penicillins, sodium bicarbonate and sodium sulfadiazine.
Storage conditions
In a place protected from light at a temperature not exceeding 25°C.
Keep out of the reach of children.
Best before date
3 years. Do not use after expiration date.
Package
1 ml per dropper tube. 2 dropper tubes together with instructions for use are placed in a pack or 2 dropper tubes in a blister pack. One contour blister package along with instructions for use is placed in a pack.
Release from pharmacies
Manufacturer: RUE "Belmedpreparaty" Republic of Belarus
ATS code: S01AA11
Farm group:
Release form: Liquid dosage forms. Eye drops.
General characteristics. Compound:
Active ingredient: 3 mg of gentamicin sulfate in 1 ml of solution.
Pharmacological properties:
Pharmacodynamics. Gentamicin is characterized by a wide spectrum of antimicrobial action. Active against most gram-negative bacteria: Escherichia coli, Klebsiella spp., indole-positive and indole-negative Proteus spp., Enterobacter spp., Providencia stuartii, Salmonella spp., Shigella spp., Acinetobacter spp.; anaerobic gram-positive cocci: Staphylococcus spp. (including those resistant to penicillin). Resistance of microorganisms to gentamicin develops slowly, but strains resistant to neomycin and kanamycin are also resistant to gentamicin.
Pharmacokinetics. It is practically not absorbed into the blood when instilled into the conjunctival sac. Penetrates into the moisture of the anterior chamber of the eye, vitreous body and corneal tissue, but is not detected in the lens. Maximum levels of gentamicin are observed within 30 minutes after administration, then the concentration decreases, mainly due to washout by tear fluid, remaining at therapeutic levels for a period of up to 6 hours.
Indications for use:
Eye drops are prescribed for acute and chronic conjunctivitis, corneal ulcers, keratitis, keratoconjunctivitis, acute and chronic iritis, acute and chronic blepharitis, dacryocystitis and other infectious and inflammatory eye diseases, as well as for the prevention and treatment of purulent complications after eye surgeries.
Important! Get to know the treatment
Directions for use and dosage:
Eye drops are instilled into the conjunctival sac 3-4 times a day, 1-2 drops. The duration of treatment is up to 14 days.
Features of application:
The drug should be prescribed with caution to patients with hypersensitivity to aminoglycosides. During long-term treatment, renal and hearing function should be monitored.
Side effects:
Possible burning and irritation in the eyes, conjunctival hyperemia. In rare cases, allergic reactions are possible.
Interaction with other drugs:
The drug should not be prescribed simultaneously with other antibiotics that have oto- or nephrotoxic effects. Possible combined use with corticosteroids.
The activity of the antibiotic is reduced in the presence of sodium, potassium, calcium, magnesium cations, as well as a number of anions (sulfates, phosphates, nitrates).
Contraindications:
Hypersensitivity to the drug, severe violations kidney function. The use of the drug is contraindicated for diseases of the auditory nerve, vestibular apparatus, and during pregnancy.
Overdose:
Repeated (more than 5 times) daily instillations of the drug for a week lead to swelling of the corneal stroma.
Vacation conditions:
On prescription
Package:
Solution (eye drops) 0.3% in tube droppers of 1 ml No. 2.
Eye drops are used everywhere. The most common are medicinal drops. With their help it is possible to eliminate many ophthalmological diseases. One of these drugs is Gentamicin drops.
Gentamicin drops – effective drug aimed at treatment large quantity ophthalmological diseases. The medication has antibacterial effect. The active substance of the drug blocks the growth and reproduction of pathogenic microorganisms. When Gentamicin is used in large dosages, the membranes of bacteria are destroyed, which leads to their death.
The medication quickly eliminates such unpleasant manifestations of various diseases as:
- increased lacrimation;
- swelling of the mucous membranes of the eyes and eyelids;
- burning sensation;
The main component of medicinal drops is gentamicin sulfate. Eye drops "Gentamicin" are not the only drug with this active ingredient; there are several analogues. This makes treatment even more accessible.
Medications similar in composition and action to Gentamicin
Eye drops "Gentamicin", like many other pharmacological agents, have analogues. This makes the treatment of certain diseases even more effective and affordable, since analogues of the drug are sold in different price categories.
The most common analogues eye drops"Gentamicin" are the following drugs.
- "Dexa-Gentamicin" - eye drops and ointment. In addition to active component gentamicin sulfate, includes dexamethasone sodium phosphate. This component adds anti-inflammatory properties to the medication. This property allows the drug “Dexagentamecin” not only to treat a particular disease, but also to combat unpleasant manifestations.
- Drops "Gentamicin-Ferein". The pharmacological agent has identical action and composition. The only difference between this product and Gentamicin eye drops is the price.
- Eye drops "Gentatsikol". The medicine has a higher cost, but identical action and composition.
Despite the fact that most analogues are completely identical to the drug "Gentamicin", before replacing it with similar drug does not recommend consulting an ophthalmologist.
Sensitive microorganisms to the drug Gentamicin
Since the drug is an antibiotic wide range, its action is aimed at pathogenic microorganisms. But not all microorganisms are neutralized by the action of this antibiotic.
Gentamicin eye drops are active against the following pathogenic microorganisms:
- coli;
- streptococcus;
- shigella;
- staphylococcus;
- salmonella;
- Pseudomonas aeruginosa;
- Proteus.
A specialist can determine which bacteria caused the disease. In addition, the occurrence of some diseases is provoked only by certain microorganisms and doctors know this.
Methods of using Gentamicin eye drops and doses
As with any medicinal product, instructions are included with the drug. detailed description all indications and contraindications. You should use the drops not only following the instructions, but also the recommendations of a specialist.
As a rule, the medication is used topically, 3-4 times a day. Dosing is carried out in drops. One procedure requires 1-2 drops. The duration of the therapeutic course should not exceed 2 weeks.
Permissible for an adult long-term use- on the recommendation of a specialist. It is also used for children this drug, but with extreme caution. This is due to the fact that pharmacological agent has a detrimental effect on the kidneys and ear canal. Use gentamicin drops in childhood allowed no longer than one week under the close supervision of a specialist.
Indications for the use of Gentamicin eye drops
The medication is often used in ophthalmic practice for therapy infectious diseases, as well as as a preventive therapy after previous surgical interventions or injuries. Prevention is carried out to prevent infection.
Pharmacological drops are effective for:
- blepharitis;
- conjunctivitis of various etiologies;
- keratitis;
- dacryocystitis;
- iridocyclitis.
There are other pathologies for which specialists prescribe the drug Gentamicin. Quite often, the drug is used as part of complex therapy.
Contraindications to Gentamicin
In some cases, the medication may cause allergic reaction Therefore, it should be used with caution by people prone to allergies. If a negative reaction to the components included in the drug was previously noticed, it should not be used.
Required to show special caution when used by persons with pathologies of the kidneys and auditory nerve, since the medication has harmful influence to these organs.
During pregnancy and lactation, a pharmacological agent is permissible for use if all the risks and threats to the child and fetus have been compared below positive influence on the mother.
Gentamicin overdose
Since the introduction of gentamicin-based eye drops, no cases of overdose have been reported. This is due to dosage form drug. One bottle of solution contains 5 mg active substance, this is relatively small. Maximum amount active component is calculated at the rate of 5 mg per kilogram of human weight.
When absorbed medical product no cases of overdose were recorded internally, also based on the low concentration of the drug in one bottle. If the product gets into the stomach, you should visit a specialist to rule out negative consequences, for example, allergic reactions.
Note! Get full information You can learn more about the medication from a specialist. You should not self-medicate, since treating one pathology can provoke another.
Often used in the treatment of bacterial infections combination drugs, in which antibiotics are combined with other substances that help eliminate inflammation. One of them is Dex-Gentamicin.
Release form
Compound
Each form of Dex-Gentamicin contains two active ingredients. These are the antibiotic gentamicin (its dosage in 1 ml drops and 1 g ointment is 3 mg) and the glucocorticoid dexamethasone (in drops it is presented in a dose of 1 mg/1 ml, and in ointment - 300 mcg/1 g). Additionally liquid form medicines include potassium hydrogen phosphate and dihydrogen phosphate, preservative (benzalkonium chloride), sodium chloride and water. If we talk about ointment, it can be noted that active substances supplemented with lanolin, liquid paraffin and white petroleum jelly.
Operating principle
Thanks to the combination of a hormone and an antibiotic, Dex-Gentamicin has both anti-inflammatory and antibacterial effects. This remedy is also used against allergies. The use of drops or ointments inhibits most microbes, including pseudomonas, coli, staphylococci, salmonella, klebsiella and many other microorganisms.
Indications
Most often, Dex-Gentamicin is used in ophthalmology. He is prescribed for local treatment pathologies such as keratitis, conjunctivitis, barley or blepharitis, if their causative agent is microbes sensitive to gentamicin.
The medicine is also in demand for allergic eye damage, if it is accompanied by bacterial infection. In addition, the medication is used during postoperative period, if you want to prevent or eliminate eye inflammation after surgical treatment.
ENT doctors can prescribe Dexa-Gentamicin for rhinitis, nasopharyngitis, sinusitis or adenoiditis of a bacterial nature. The drug may also be included in the composition complex drops into the nose, the prescription of which is selected individually for each patient.
At what age is it allowed to take it?
The annotation for drops and ointments contains information that Dexa-Gentamicin is contraindicated in patients under 18 years of age. However, in practice, this drug is often prescribed to children, but only a specialist should assess the feasibility of such treatment and determine the dosage. It is unacceptable to give medication to a child without the consent of a doctor.
Contraindications
"Dexa-Gentamicin" is not prescribed:
- If you are hypersensitive to any ingredient of the medicine.
- At viral lesions eye - for example, with chickenpox.
- When the eyes are damaged by fungi.
- For acute purulent lesions, if the corneal epithelium is damaged.
- For corneal injuries.
- With increased intraocular pressure.
- When using contact lenses.
Side effects
The medicine may cause allergies or a burning sensation at the site of use.
In rare cases, the use of Dex-Gentamicin leads to a fungal infection, corneal perforation or herpetic keratitis. Very long-term use increases the risk of developing glaucoma or cataracts.
For ophthalmological diseases, the Dex-Gentamicin solution is dripped into each eye, 1-2 drops up to 6 times a day. The frequency of use of the ointment is 2-3 times a day, and for one application, take a strip of the drug approximately 1 cm long. The duration of therapy is usually 2-3 weeks and is determined by the doctor individually.
