Daily requirement of ascorbic acid. Treatment and prevention of vitamin deficiency and hypovitaminosis

G-Lactone 2,3-dehydro-L-gulonic acid.

Description

Vitamin C is a water-soluble vitamin. First isolated in 1923-1927. Zilva (S.S. Zilva) from lemon juice.

According to the results of numerous scientific research ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, in the synthesis steroid hormones, collagen; increases the body's resistance, reduces vascular permeability, which is important for various capillary bleeding, infectious diseases, nasal, uterine and other bleeding. Helps maintain healthy condition skin, participates in immune reactions, improves iron absorption. Has antioxidant properties.

Playing important role at work immune system, helping to increase the body's resistance to viral and bacterial infections.

For diseases accompanied by fever, as well as increased physical and mental stress The body's need for vitamin C increases.

Vitamin C is one of the body's defense factors against the effects of stress. Strengthens reparative processes. There are theoretical and experimental prerequisites for the use of vitamin C to reduce the risk of developing cancer.

Sources of ascorbic acid

Significant amount ascorbic acid contained in products plant origin(citrus fruits, leafy green vegetables, melon, broccoli, Brussels sprouts, cauliflower and cabbage, black currants, bell pepper, strawberries, tomatoes, apples, apricots, peaches, persimmons, sea buckthorn, rose hips, rowan, baked jacket potatoes). It is present insignificantly in products of animal origin (liver, adrenal glands, kidneys).

Herbs rich in vitamin C: alfalfa, mullein, burdock root, chickweed, eyebright, fennel seed, fenugreek, hops, horsetail, kelp, peppermint, nettle, oats, cayenne pepper, red pepper, parsley, pine needles, yarrow, plantain , raspberry leaf, red clover, skullcap, violet leaves, sorrel.

		Name of food products	Amount of ascorbic acid
Vegetables		Fruits and berries		Eggplant	5	Apricots	10	Canned green peas	10	Oranges	50	Fresh green peas	25	Watermelon	7	Zucchini	10	Bananas	10	White cabbage	40	Cowberry	15	Sauerkraut	20	Grape	4	Cauliflower	75	Cherry	15	Potatoes are stale	10	Pomegranate	5	Freshly picked potatoes	25	Pear	8	Green onion	27	Melon	20	Carrot	8	Garden strawberries	60	Cucumbers	15	Cranberry	15	Sweet green pepper	125	Gooseberry	40	Red pepper	250	Lemons	50	Radish	50	Raspberries	25	Radish	20	Tangerines	30	Turnip	20	Peaches	10	Salad	15	Plum	8	Tomato juice	15	Red currants	40	Tomato paste	25	Black currant	250	Red tomatoes	35	Blueberry	5	Horseradish	110-200	Dried rosehip	Up to 1500	Garlic	Footprints	Apples, Antonovka	30	Spinach	30	Northern apples	20	Sorrel	60	Southern apples	5-10	Dairy				Kumis	20	Mare's milk	25	Goat milk	3	Cow's milk	2

Remember that few people, and especially children, eat enough fruits and vegetables, which are the main food sources vitamin A. Cooking and storage lead to the destruction of a significant part of vitamin C. In states of stress, exposure unfavorable factors environment(smoking, industrial carcinogens, smog) vitamin C is consumed faster in tissues.

To prevent hypovitaminosis, rose hips are often used. Rose hips differ relatively high content ascorbic acid (not less than 0.2%) and are widely used as a source of vitamin C. The fruits of different types of rose hips collected during the ripening period and dried are used. They contain, in addition to vitamin C, vitamins A, E, sugar, organic acids, alimentary fiber. Used in the form of infusion, extracts, syrups.

An infusion of rose hips is prepared as follows: 10 g (1 tablespoon) of the fruit is placed in an enamel bowl, pour 200 ml (1 glass) of hot boiled water, close the lid and heat in a water bath (in boiling water) for 15 minutes, then cool at room temperature at least 45 minutes, filter. The remaining raw materials are squeezed out and the volume of the resulting infusion is adjusted boiled water up to 200 ml. Take 1/2 cup 2 times a day after meals. Children are given 1/3 glass per dose. To improve the taste, you can add sugar or fruit syrup to the infusion.

Daily requirement for ascorbic acid

A person’s daily need for vitamin C depends on a number of reasons: age, gender, work performed, physiological state of the body (pregnancy, breastfeeding, presence of disease), climatic conditions, availability bad habits.

Illness, stress, fever and exposure toxic substances (cigarette smoke, chemicals) increase the need for vitamin C.

In hot climates and in the Far North, the need for vitamin C increases by 30-50 percent. A young body absorbs vitamin C better than an older one, so in older people the need for vitamin C is slightly increased.

It has been proven that contraception (oral contraceptives) lower the level of vitamin C in the blood and increase daily requirement in him.

The weighted average physiological requirement for the vitamin is 60-100 mg per day.

Table. Norms of physiological requirement for vitamin C [MP 2.3.1.2432-08]

The body quickly uses up incoming vitamin C. It is advisable to constantly maintain a sufficient supply of vitamin C.

Signs of hypervitaminosis

Vitamin C is generally well tolerated in doses up to 1000 mg/day.

When too large doses Diarrhea may develop after taking it.

Large doses may cause hemolysis (destruction of red blood cells) in people lacking the specific enzyme glucose-6-phosphate dehydrogenase. Therefore, people with this disorder can take higher doses vitamin C only under the strict supervision of a doctor.

When using large doses of ascorbic acid, pancreatic function may be impaired with impaired insulin synthesis.

Vitamin C promotes the absorption of iron in the intestines.

Gummies and chewing gum with vitamin C can damage tooth enamel, so you should rinse your mouth or brush your teeth after taking them.

Large doses should not be taken by people with increased blood clotting, thrombophlebitis and a tendency to thrombosis, as well as diabetes. At long-term use large doses of ascorbic acid may inhibit the function of the insular apparatus of the pancreas. During treatment, it is necessary to regularly monitor its functional ability. Due to the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, during treatment with large doses, it is necessary to monitor renal function, blood pressure and the level of hormones in the blood.

The maximum permissible intake level of vitamin C for adults is 2000 mg/day ( Guidelines“Norms of physiological needs for energy and nutrients For various groups population Russian Federation", МР 2.3.1.2432-08)

Symptoms of hypovitaminosis

According to the head of the laboratory of vitamins and minerals Institute of Nutrition of the Russian Academy of Medical Sciences prof. V.B. Spirichev, the results of surveys in different regions of Russia show that the vast majority of preschool and school age lacks what they need normal height and development of vitamins.

The situation is especially unfavorable with vitamin C, the deficiency of which was identified in 80-90% of the children examined.

When examining children in hospitals in Moscow, Yekaterinburg, Nizhny Novgorod and other cities, vitamin C deficiency is found in 60-70%.

The depth of this deficiency increases in the winter-spring period, however, in many children, an insufficient supply of vitamins persists even in the more favorable summer and autumn months, that is, it is year-round.

But insufficient consumption vitamins significantly reduces the activity of the immune system, increases the frequency and severity of respiratory and gastrointestinal diseases. According to domestic researchers, a lack of ascorbic acid in schoolchildren halves the ability of leukocytes to destroy pathogenic microbes that have entered the body, resulting in the frequency of acute respiratory diseases increases by 26-40%, and vice versa, taking vitamins significantly reduces the incidence of acute respiratory infections.

Deficiency can be exogenous (due to low content ascorbic acid in food products) and endogenous (due to impaired absorption and digestibility of vitamin C in the human body).

If there is insufficient vitamin intake over a long period of time, hypovitaminosis may develop. Possible signs Vitamin C deficiency:

• bleeding gums
• cyanosis of lips, nose, ears, nails, gums
• swelling of the interdental papillae
• ease of bruising
• poor healing wounds
• lethargy
• hair loss
• pale and dry skin
• irritability
• joint pain
• feeling of discomfort
• hypothermia
• general weakness

Preservation of vitamin C during cooking

Name of dishes	Preservation of vitamin compared to the original raw material in %
Boiled cabbage with broth (cooking 1 hour)	50	Cabbage soup standing on a hot plate at 70-75° for 3 hours	20	Same with acidification	50	Cabbage soup standing on a hot plate at 70-75° for 6 hours	10	Sauerkraut cabbage soup (cooking 1 hour)	50	Stewed cabbage	15	Potatoes, fried raw, finely chopped	35	Potatoes boiled for 25-30 minutes in their skins	75	Same, cleaned	60	Peeled potatoes, kept in water at room temperature for 24 hours	80	Mashed potatoes	20	Potato soup	50	The same, standing on a hot stove at 70-75° for 3 hours	30	Same thing, standing for 6 hours	footprints	Boiled carrots	40

From the book by O.P. Molchanova "Fundamentals" rational nutrition", Medgiz, 1949.

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When studying the effect of vitamin C on passive smokers, it was found that people staying in smoky rooms experience oxidative stress, which accelerates the progression of atherosclerosis.

Conclusion: passive smokers require vitamin C supplementation.

* dietary supplement. NOT A MEDICINE

Hypovitaminosis is a condition caused by a lack of vitamin in the body. Since this phenomenon is quite common, let's briefly go over the symptoms:

Vitamin A deficiency — « night blindness"(if you see almost nothing at dusk, this is it), frequent conjunctivitis, dry skin, dry and brittle hair, dandruff, pustular diseases on the skin, increased sensitivity of tooth enamel.

IN 1- violations by nervous system: insomnia, irritability, decreased memory and ability to concentrate, feeling of numbness in the limbs. With hypovitaminosis B1, the heart and gastrointestinal tract also suffer (hello, gastritis, hello, ulcer duodenum!). Attention, people who drink! Of all the vitamins, this is the one you need the most. Otherwise, you will have to get acquainted with Korsakoff's syndrome, and this acquaintance is very unpleasant: absolutely everything falls out of memory, immediately after it happened and never returns. That is, you can pay for the same bottle of beer a hundred and fifty times in a sober mind and go to the cash register again. By the way, frequent and abundant communication with the green serpent invariably leads to a deficiency of B vitamins in the body, I recommend remembering this.

AT 2– visual disturbances, pain in the eyes, headache, loss of appetite.

AT 5– the symptoms are similar to the symptoms of vitamin B1 deficiency, that is, first of all it affects the nervous system. Symptoms of skin sensitivity disorders are more pronounced: burning, itching and other joys, sometimes worsening at night. In addition, muscle pain is observed.

AT 6– again the nervous system takes the brunt of it: dizziness, lethargy, fatigue, anxiety, depression. Plus, this vitamin deficiency is often written on the face in the literal sense: dermatitis and dermatoses with a very unpleasant localization, around the eyes, for example, or - be horrified ladies - in the décolleté area. Chapped lips.

AT 9- also a sad vitamin deficiency and also vile, because it reduces the absorption of vitamin B12. It is expressed in anemia, and again in damage to the nervous system - fatigue, insomnia, apathy. In pregnant women, it can cause serious damage to the fetus.

AT 12(by the way, be curious, the vitamin has a very beautiful formula, it will immediately become clear to you that it’s somehow a shame to be left without this beauty in the body - digestive disorders, constipation, depression, anemia, ringing in the ears, drowsiness (strange, right? There’s a ringing in the ears , but I want to sleep), Attention, vegetarians! If you do not take any supplements, then sooner or later you will have to deal with this hypovitaminosis, because. And yet - everyone, even short-term B12 deficiency has a very strong impact on the nervous system.

WITH- an old acquaintance, in the absence of which you will be primarily concerned about the fragility of blood vessels (there is even a tourniquet test - a tourniquet is tightened on the arm, and if after this tiny hemorrhages - petechiae - appear on the skin, it means that there is increased fragility of the capillaries, and it’s time to dig in teeth in lemon), hair loss, frequent mysterious appearance of bruises, poor healing of even small scratches, bleeding gums, joint pain.

D- Well, adults are not at risk of rickets. However, a burning sensation in the mouth and throat, loss of appetite and insomnia can significantly spoil your mood.

E- weakness, muscular dystrophy(well, that is, you walk, go to the gym, but the muscles don’t grow, and what’s even worse, they decrease). It can be very unpleasant with the liver - with a lack of vitamin E, necrosis and dystophys are described in it. Attention! The need for the vitamin is increased in people with high physical activity.

N– the most unpleasant thing that this vitamin deficiency can lead to is an increase in the level of glucose and cholesterol in the blood. In addition - seborrhea, dry skin, hair loss, weakness, anemia, muscle pain.

RR (aka B3)– burning in the extremities, redness on the skin followed by peeling, disruption of the nervous system up to dementia, cracks in the skin, inflammation, weakness, disorders of cholesterol and glucose metabolism.

TO– increased bleeding of everything and everyone in the body.

For normal functioning Our body desperately needs vitamins. Including very important, also known as “ascorbic acid”. In our article we will talk about its benefits, the reasons for deficiency and excess, and also give the daily requirement depending on age.

Ascorbic acid(colloquially - ascorbic acid) belongs to the group, is a powerful antioxidant, regulates redox processes, takes an active part in the production of collagen and procollagen, is necessary for metabolic processes folic acid And .
Thanks to its effect, the blood clotting rate is regulated and the condition of the capillaries is normalized. In addition, it has anti-inflammatory and antiallergic effects.

Important! You should not take vitamin C on an empty stomach, as it increases acidity, which can cause the development of gastrointestinal diseases.

Ascorbic acid protects the body from negative impacts and stress. In addition, it helps to enhance reparative processes and increase resistance to various infections.

Due to its water solubility, it cannot accumulate in the body, so its supply must be constantly replenished.

Daily consumption rate

Depending on age, the human body requires different amounts of ascorbic acid. Let's consider the daily dosage.

For babies

The daily intake for infants under 5 months is 30 mg. From six months you can increase the dosage to 35 mg per day.

For girls and boys aged 1 to 3 years daily dosage is 40 mg, from 4 years to 10 years of age the norm can be increased to 45 mg, and from 10 to 11 years old child You can give 50 mg per day.

For boys and girls

For both boys and girls daily norm ascorbic acid is 60 mg.

For adults

For adults, the daily dose of ascorbic acid is 90 mg for men and 75 mg for women.

For the elderly

The daily intake of ascorbic acid for people over 50 years of age is 100 mg.

During illness, the immune system weakens, so human body needs increased dosage. It is recommended to consume 500-1000 mg every day, depending on the patient’s condition.

For pregnant

During pregnancy, the daily dose increases, since not only the woman, but also the fetus needs ascorbic acid. It is recommended to take 200-400 mg of ascorbic acid every day. During lactation, the norm should also be increased.

For athletes

Since athletes are exposed to great physical activity, the daily dose for them is significantly higher than for ordinary person, and is 200-300 mg.

We present to your attention a list of products with the greatest content ascorbic acid (per 100 g of product):

• - 450-600 mg;
• red pepper - 180-250 mg;
• black currant - 180-200 mg;
• green pepper - 130-150 mg;
• - 100-120 mg;
• - 80-90 mg;
• - 70 mg;
• - 50-60 mg;
• - 50-60 mg;
• - 45 mg;
• - 40-45 mg;
• - 30-40 mg;
• - 15-20 mg.

How is vitamin preserved during cooking?

Let's look at the example of potatoes, fresh cabbage and sauerkraut what is the loss of vitamin C during different types processing.

Potato:

• when boiling in their uniforms, if immersed in cold water - 25%;
• during normal cooking, if immersed in cold water - 35%;
• during normal cooking, if immersed in boiling water - 75%;
• if cooked in soup - 50%;
• if stewed - 80%;
• if you make puree - 72-88%.

Fresh cabbage:

• if cooked in soup - 20-50%;
• if you simmer - 70%.

• if cooked - 50%;
• if stewing - 20-65%.

Unfortunately, it is not always possible to obtain the required amount of ascorbic acid for the body from foods. In this case, special medications that can be purchased at the pharmacy come to the rescue.

• "Vitamin C Nycomed";
• "Asvitol";
• "Vitrum plus vitamin C";
• "Upsavit vitamin C."

In addition, at any pharmacy you can purchase the well-known ascorbic acid in tablets packaged in the form of a large candy. Most often, one tablet contains 25 mg of ascorbic acid. The advantage of this drug is its interesting packaging and good taste. They come in strawberry, raspberry, orange and other flavors that kids really like.

Did you know? The body of many animals, for example, cats, is capable of independently synthesizing vitamin C from glucose, unlike the human body, which has lost this ability and is forced to receive ascorbic acid either through food or through the use of medications.

Possible problems: danger of excess vitamin C

Do not think that the more you consume ascorbic acid, the better. An excess of ascorbic acid can be harmful.

The WHO Committee introduced special concepts “unconditionally permissible daily dose of vitamin C” and “conditionally permissible dose vitamin C." The first is calculated at the rate of 2.5 mg per 1 kg of body weight, and the second - 7.5 mg per 1 kg of body weight.

Exceeding the conditionally permissible dose is the reason that occurs in such situations:

• in winter and spring, in order to protect themselves from diseases, people often unnecessarily exceed the dosage;
• consuming large amounts of foods containing ascorbic acid;
• taking too large doses to treat illnesses.

Symptoms

The main symptoms include:

• diarrhea;
• nausea;
• dizziness;
• allergic reactions on the skin;
• stomach irritation;
• decreased concentration;
• damage to tooth enamel;
• increased blood pressure;
• deterioration in the functioning of the pancreas.

In addition to possible similar effects, ascorbic acid should be taken with extreme caution by people suffering from diabetes mellitus having increased blood clotting and a tendency to form blood clots.

What to do

There are two types of overdose: chronic and one-time. In chronic cases, it is recommended to drink a lot of water. Thanks to the incoming water, the kidneys can quickly remove the substance from the body.

Important! Young children should be given ascorbic acid gradually, starting with very small doses, as it can cause allergic reactions.

The second type is a one-time overdose. Most often it occurs if the permissible dose is exceeded by 20 or more times. In this case, you need to start taking certain measures as soon as possible so that the acid does not have time to be absorbed, namely:

Perform stomach cleansing. To do this, induce vomiting and drink a large number of water. This will help prevent dehydration, the stomach will be flushed, and the acid will not enter the blood. Take activated carbon.

If you realize that you have consumed too much ascorbic acid, you need to temporarily eliminate foods containing it from your diet.

What are the dangers of vitamin C deficiency?

A lack of ascorbic acid in the body can also lead to negative consequences.

The main causes of hypovitaminosis include:

• poor nutrition- insufficient amount of vegetables and fruits in the menu, their consumption after heat treatment;
• presence of gastrointestinal diseases- as a result, the absorption of acid in the intestine is impaired;
• metabolic disease, malfunctions thyroid gland - at the same time, vitamins are intensively removed from the body;
• periods, when the body needs ascorbic acid more than usual- pregnancy, lactation, infections, stress.

Symptoms

Among the main symptoms of hypovitaminosis are the following:

• a feeling of fatigue quickly sets in;
• performance is significantly reduced;
• colds occur frequently;
• headache;
• felt throughout the day severe irritability;
• problems with sleep are noted;
• the skin became pale;
• often aches muscles;
• in case of defeat skin bleeding increases.

Did you know? Nowadays, all animals, plants and people need vitamin C. There is only one exception - yeast: they need a completely different form of ascorbic acid.

What to do

To replenish the concentration of vitamin C in the body, use the following recommendations:

• include more fruits and vegetables in your diet;
• give up bad habits - smoking and drinking alcohol;
• avoid stress and hypothermia;
• sleep at least 8 hours;
• Take 100-200 mg of vitamin C daily.

In order not to harm your health, you should be especially careful with the dosage of ascorbic acid. You should not exceed the recommended dose, and if you have any diseases, you should consult with your doctor about whether you can take a particular dose.

In addition, under no circumstances should you engage in self-diagnosis or prescribe ascorbic acid without your doctor’s knowledge. Remember that taking too much or too little can significantly harm your health.

Useful vitamins

In addition to ascorbic acid, there are other healthy vitamins. Let's look at them.

Vitamin A

This vitamin belongs to the group. It is necessary to maintain in good condition vision, for healthy bones, skin, hair and the proper functioning of the immune system. The daily requirement for an adult is 900 mcg for men and 700 mcg for women.

This vitamin promotes absorption in the body and is necessary for the proper development of teeth and bone tissue. In addition, it is needed for the normal functioning of the nervous system. The daily norm for an adult is 5 mcg.

Vitamin E

Thanks to its presence in the body, tissue regeneration occurs much faster and blood circulation improves. It is also used in the treatment of many women's diseases, improves the condition of skin and hair. Daily dose for adult women it is 8IU, for men - 10E.

So, ascorbic acid, like other vitamins, is very important for the normal functioning of the body. However, care must be taken to avoid a deficiency or excess of these substances. They can be beneficial only when consumed in moderation.

Tradename: ASCORBIC ACID

International nonproprietary name:

Ascorbic acid.

Dosage form:

dragee.

Compound:

Composition for one dragee:
Active substance: 0.05 g ascorbic acid;
Excipients: sugar, starch syrup, wheat flour, sunflower oil, beeswax, talc, food flavorings, yellow dye E 104.

Description
Dragee greenish-yellow or yellow color regular spherical shape. The surface of the dragee must be flat, smooth, and uniform in color.

Pharmacotherapeutic group
Regulating agent metabolic processes.
Vitamin preparation.

ATX code A11GA01

Pharmacological properties
Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.

Indications for use
Prevention and treatment of hypo- and vitamin C deficiency;
As aid: hemorrhagic diathesis, nasal, uterine, pulmonary and other bleeding, against the background radiation sickness; overdose of anticoagulants, infectious diseases and intoxication, liver disease, nephropathy of pregnancy, Addison's disease, slow-healing wounds and bone fractures. dystrophies and others pathological processes. The drug is prescribed for increased physical and mental stress, during pregnancy and breastfeeding, during the period of recovery after serious long-term illnesses.

Contraindications
Increased sensitivity to the components of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus.

Carefully: hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia. Progressive malignant diseases, pregnancy.

Directions for use and doses
The drug is taken orally after meals.
For prevention: adults 0.05-0.1 g (1-2 tablets) per day, children from 5 years old 0.05 g (1 tablet) per day.
For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times a day, children from 5 years old 0.050.1 g (1-2 tablets) 2-3 times a day.
During pregnancy and breastfeeding, 0.3 g (6 tablets) per day for 1015 days, then 0.1 g (2 tablets per day) per day.

Side effect
From the central nervous system (CNS): headache, feeling of fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.
From the outside digestive system: mucosal irritation gastrointestinal tract, nausea, vomiting, diarrhea, stomach cramps.
From the outside endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
From the urinary system: when used in high doses-hyperoxalaturia and education urinary stones from calcium oxalate.
From the outside of cardio-vascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy Allergic reactions: skin rash, rarely - anaphylactic shock.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Other: hypervitaminosis, feeling of heat, with prolonged use of large doses - sodium (Na +) and fluid retention, metabolic disorders of zinc (Zn 2+), copper (Cu 2+).

Overdose
When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating or red urine, and hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency) are possible.
If any side effects you should stop taking the drug and consult a doctor.

Interaction with others medicines
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol.
Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when simultaneous use with deferoxamine.
Acetylsalicylic acid(ASA), oral contraceptives, fresh juices And alkaline drink reduce absorption and absorption.
When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.
Increases the risk of developing crystalluria when treated with salicylates and sulfonamides short acting, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Quinoline drugs (fluoroquinolones, etc.), calcium chloride, salicylates, and glucocorticosteroids with long-term use deplete ascorbic acid reserves.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.
In high doses, it increases the renal excretion of mexiletine.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces therapeutic effect antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

special instructions
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.
With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with increased content iron in the body, ascorbic acid should be used in minimal doses.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).
Use during pregnancy and breastfeeding
The minimum daily requirement for ascorbic acid is P-P trimesters pregnancy - about 60 mg.
The minimum daily requirement during breastfeeding is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in infant(it is recommended that a nursing mother not exceed the maximum daily requirement for ascorbic acid).

Release form
200 tablets in polymer jars BP-60-X or BP-60, or “BP-60-X with stopper”.
The stopper (case) of the “BP-60 X with stopper” can contains instructions for medical use without putting the can into the pack.
A polymer jar BP-60-X or BP-60 is placed in a cardboard pack along with instructions for medical use.

Best before date
1 year 6 months.
Do not use after the date indicated on the package.

Storage conditions
In a dry place, protected from light.
Keep out of the reach of children.

Conditions for dispensing from pharmacies
Over the counter

Manufacturer and organization accepting claims:
JSC Pharmstandard-UfaVITA, 450077 Ufa, st. Khudayberdina, 28.